DNA Sequencing Equipment and Services Markets

Content

• Chapter One: Executive Summary
  • Dna Sequencing Applications
  • Types Of Samples
  • Market Trends
  • Scope And Methodology
• Chapter Two: Introduction
  • Background
  • Dna Sequencing Applications
  • Types Of Samples
  • Dna Sequencing Strategies
  • Dna Sequencing Chemistries And Techniques
    • Sanger Sequencing
    • Single Nucleotide Addition; Pyrosequencing
    • Cyclic Reversible Terminators
• Chapter Three: Sequencer Market Trends And
  • Funding Trends
  • Market Trends
    • Market Fragmenting Into Multiple Applications, Products
    • Synergies Appearing Between Companies' Products
  • Microbes And Metagenomics Gaining Importance
  • Various Disruptive Technologies Rapidly Appearing On Market
  • Miniaturization Of Sanger And Ce Technology
  • Paired-End Techniques, Increasing Read-Lengths Expanding Applications
    • Development Of Multiplexing Approaches Extends Market
    • Snp And Other Experiments Moving To Sequencing For Higher Detail
    • Continued Rapid Growth In Sequence Production
  • Funding Trends
    • Funding And Consortia For Sequencing
    • The Cancer Genome Atlas Pilot Project
  • Cancer Sequencing Project
  • Fuge - Functional Genomics In Norway
  • Nsf / Usda Microbial Genome Sequencing Program
  • Other Funding
• Chapter Four: Dna Sequencer Products
  • 454 Life Sciences (Branford, Ct) / Roche
  • Genome Sequencer 20
  • Genome Sequencer Flx.
  • Applied Biosystems (Foster City, Ca)
    • Abi Prism 310 Genetic Analyzer
    • Abi Prism 3100-Avant Genetic Analyzer
    • Applied Biosystems 3100 Genetic Analyzer
    • Applied Biosystems 3130 Genetic Analyzer
    • Applied Biosystems 3130xl Genetic Analyzer
    • Applied Biosystems 3730 Dna Analyzer
    • Applied Biosystems 3730xl Dna Analyzer
    • Solid (Early Access)
  • Beckman Coulter
    • Ceq 8000; Ceq 8800
    • Ge Healthcare
    • Megabace 500.
    • Megabace 750
    • Megabace 1000
    • Megabace 1500
    • Megabace 4000
  • Illumina / Solexa
  • Illumina Genome Analyzer
  • Li-Cor Biosciences (Lincoln, Ne)
  • 4300
• Chapter Five: Market Data
  • Revenues And Forecast
• Chapter Six: Competitive Analysis
  • Features And Strengths Of Next-Generation Sequencers
  • 454 Life Sciences - Strengths / Advantages
  • 454 Life Sciences - Weaknesses / Disadvantages
  • Applied Biosystems Solid - Strength / Advantages
  • Applied Biosystems Solid - Weaknesses / Disadvantages
  • Illumina Genome Analyzer - Strength / Advantages
  • Illumina Genome Analyzer - Weaknesses / Disadvantages
• Chapter Seven: Intellectual Property And Litigation
  • Affymetrix Wins Patent Infringement Case Against Illumina
  • Applied Biosystems And Amersham Plc (Ge Healthcare) Settle Sequencing Patent Litigation
  • Applied Biosystems Sues Solexa And Former Chief Patent Counsel
  • Beckman Coulter And Applied Biosystems Settle Outstanding Legal Disputes
  • Cepheid And Idaho Technology Settle Dispute Over Pcr Patents
  • Enzo Biochem Disputes Caltech Sequencing Patents
  • Huang V. Caltech
• Chapter Eight: Deals
• Chapter Nine: Corporate Profiles
  • 454 Life Sciences (Branford, Ct) / Roche
  • Applied Biosystems (Foster City, Ca)
  • Beckman Coulter (Fullerton, Ca)
  • Ge Healthcare Life Sciences (Little Chalfont, Uk)
  • Helicos Biosciences (Cambridge, Ma)
  • Illumina / Solexa
  • Intelligent Bio-Systems (Waltham, Ma)
  • Li-Cor Biosciences (Lincoln, Ne)
  • Nabsys (Providence, Ri)
• Chapter Ten: Technologies Under Development
  • Nhgri Funds Next Generation Of Sequencing Technologies
  • 454 Life Sciences Corp

  • "Massively Parallel High Throughput, Low Cost Sequencing"

    • "454 Life Sciences Massively Parallel System Dna Sequencing"

  • Agencourt Personal Genomics [Applied Biosystems]

  • "Bead-Based Polony Sequencing"

  • Arizona State University, Tempe

  • "Multiplexed Reactive Sequencing Of Dna"

  • Baylor College Of Medicine, Human Genome Sequencing Ctr

  • "Ultrafast Sbs Method For Large-Scale Human Resequencing"

  • Columbia University

  • "An Integrated System For Dna Sequencing By Synthesis"

  • Harvard University, Rowland Institute; Moved To Boston Univ.

  • "Ultra-Fast Nanopore Readout Platform For Designed Dna's"

  • Li-Cor Inc.

  • "Single-Molecule Dna Sequencing Using Charge-Switch Dntps"

  • Microchip Biotechnologies Inc

  • "Microbead Integrated Dna Sequencer (Minds) System"

  • Stanford University

  • "High-Throughput, Single-Molecule Dna Sequencing"

  • Stanford Genome Technology Center

  • "Pyrosequencing Array For Dna Sequencing"

  • University Of Gainesville, Florida

  • "Dna Sequencing Using Nanopores"

  • "Polymerases For Sequencing By Synthesis"

  • Second Group Of Grants, $1000 Genome
  • Arizona State University, Tempe

  • "Molecular Reading Head For Single-Molecule Dna Sequencing"

  • Oak Ridge National Laboratory

  • "Experimental R&D For Rapid Sequencing Nanotechnology"

  • "Computational R&D For Rapid Sequencing Nanotechnology"

  • Stanford University

  • "Single Molecule Nucleic Acid Detection With Nanopipettes"

  • University Of British Columbia, Vancouver

  • "Nanopores For Trans-Membrane Bio-Molecule Detection"

  • University Of Maine, Orono

  • "High-Speed Nanopore Gene Sequencing"

  • University Of North Carolina, Chapel Hill

  • "Nanotechnology For The Structural Interrogation Of Dna"

  • Nhgri Expands Effort To Revolutionize Sequencing Technologies
  • Agencourt Personal Genomics [Applied Biosystems]

  • "Bead-Based Polony Sequencing (Supplemental)"

  • Network Biosystems

  • "$100,000 Genome Using Integrated Microfluidic Ce"

  • The State University Of New York, Stony Brook (Suny)
  • "Ultra High Throughput Dna Sequencing System Based On 2d Monolith
  • Multi-Capillary Arrays And Nanoliter Reaction Volume"
  • Columbia University

  • "Modulating Nucleotide Size In Dna For Detection By Nanopore"

  • Duke University

  • "Droplet-Based Digital Microfluidic Genome Sequencing"

  • Harvard University

  • "Electronic Sequencing In Nanopores"

  • Nanofluidics

  • "Real-Time Multiplex Single-Molecule Dna Sequencing"

  • New York University

  • "Haplotype Sequencing Via Single Molecule Hybridization"

  • Oxford University And The Scripps Research Institute

  • "Single-Molecule Dna Sequencing With Engineered Nanopores"

  • University Of California, San Diego

  • "Massively Parallel Cloning And Sequencing Of Dna"

  • University Of Illinois At Urbana-Champaign

  • "Sequencing A Dna Molecule Using A Synthetic Nanopore"

  • Visigen Biotechnologies

    • "Real-Time Dna Sequencing"

    • "Nhgri Aims To Make Dna Sequencing Faster, More Cost Effective"

      ,

    • "Fabrication Of Universal Dna Nanoarrays For Sequencing By Hybridization"

  • Boston University

  • "High-Throughput Dna Sequencing Using Design Polymers And Nanopore Arrays"

  • Case Western Reserve University

  • "Large-Scale Nanopore Arrays For Dna Sequencing"

  • General Electric Global Research

  • "Closed Complex Single Molecule Sequencing"

  • Helicos Biosciences

  • "High Accuracy Single Molecule Dna Sequencing By Synthesis"

  • Lehigh University

  • "Force Spectroscopy Platform For Label Free Genome Sequencing"

  • University Of California, San Diego

  • "Genome Sequencing By Ligation Using Nano-Arrays Of Single Dna Molecules"

  • University Of North Carolina, Chapel Hill

  • "Nanoscale Fluidic Technologies For Rapidly Sequencing Single Dna Molecules"

  • University Of Washington, Seattle

  • "Engineering Mspa For Nanopore Sequencing"

  • Baylor College Of Medicine, Hgs

  • "Ultrafast Sbs Method For Large-Scale Human Resequencing"

  • Intelligent Bio-Systems

  • "High-Throughput Dna Sequencing By Synthesis Platform"

  • Other Microfluidics And Lab-On-A-Chip
• Chapter Eleven: Challenges And Strategic
  • Recommendations
  • Market Challenges
  • Saturation, Technology Advances Threaten Market Growth
    • Next-Generation Vendors Contending With 454's Head-Start
    • Rapid Changes, Multiple Variables Creating Unpredictable Market
    • Labs Hesitant To Invest In Unproven Technologies
    • Segments Resisting Change Where Long Read-Lengths Key
    • New Technologies Create Data Management Issues
    • Recent Acquisitions Make Tougher Environment For New Entrants
  • Strategic Recommendations
    • Increase Products' Value Through Software Tools
    • Explore Demand In Expanding Industry Segments
    • Address Niche Markets Resulting From Fragmentation
    • Increase Value By Combining With Complementary Content
    • Establish Early Connections With End-Users
    • Balance Risks By Diversifying Applications
    • Move Towards Diagnostic Environment Requires Partnering
• Table Of Exhibits
• Chapter One: Executive Summary
  • Table 1-1: Dna Sequencer Equipment Revenues 1999-2006
  • Figure 1-1: Trending In The Dna Sequencer Equipment Market 2006-2012
• Chapter Three: Sequencer Market Trends And Funding Trensd
  • Figure 3-1: Distribution Of Archaeal And Bacterial Genome Projects, Q1 2007
  • (Jgi, Tigr, J Venter, World)
  • Figure 3-2: Phylogenetic Distribution Of Bacterial Genome Projects, Q1 '07
  • Figure 3-3: Number Of Completely Sequenced Genomes (Published Vs
  • Unpublished) 1999 Through Q1 2007
  • Figure 3-4: Distribution Of Number Of Projects Among Major Sequencing Centers Q1 2007
  • Figure 3-5: Funding By The Top Agencies In Dna Sequencing
  • Figure 3-6: U.S. Funding For The Human Genome Project Doe Vs Nih 1990-2003
  • Figure 3-7: Distribution Of The Number Of Bacterial Sequencing Projects By Area Of Focus (Agriculture/Food, Biomedical, Biotech, Environmental, Evolutionary)
  • Table 3-1: Fuge Funding Recipients
  • Table 3-2 Large-Scale Sequencing Centers Nhgri Funding, 2007
  • Figure 3-8: Nhgri Funding Of Large-Scale Sequencing Centers By Organization 2004-2006 (Cumulative)
  • Figure 3-9: Nhgri Funding Of Large-Scale Sequencing Centers By Organization 2007 Figure 3-10: Broad Institute Organizational Structure
  • Table 3-3: Nsf Plant Genome Research Project Recent Funding Awards (Title Start Date, Expiration Date, Pi, Organizatino, Funding Amount) Table 3-4: Nsf / Usda Microbial Genome Sequencing Program Recent
  • Funding Awards (Title, Start Date, Expiration Date, Pi, Organization, Funding Amount)
• Chapter Four: Dna Sequencer Products
  • Table 4-1: Key Products And Technologies Currently On The Market By Company (Company, Product/ Technology, Comments)
• Chapter Five: Market Data
  • Table 5-1: Dna Sequencer Equipment Revenues 1999-2006
  • Table 5-2: Dna Sequencer Equipment Revenues 2006-2012
  • Figure 5-1 Dna Sequencer Market, Market Share By Industry, 2006
  • Figure 5-2: Trending In The Dna Sequencer Equipment Market 1999-2006
  • Figure 5-3: Abi's Quarterly Overall Sequencing Revenues 2001 To 2006
  • Figure 5-4: Abi's Quarterly Overall Sequencing Revenues Q3 2005 To Q4 2006
  • Figure 5-5: Estimated Forecasted Price Of Sequencing A Genome 1990-2030
  • Figure 5-6: Trending In The Dna Sequencer Equipment Market, 2006-2012
• Chapter Six: Competitive Analysis
  • Table 6-1: Revenues And Market Shares Of Leading Dna Sequencer System
  • Suppliers, 2006 (Company, Market Share, Revenues, Trend)
  • Figure 6-1: Market Shares, Dna Sequencer Systems, 2006
  • Table 6-2: Comparison Of Next-Generation Sequencer System Features (Reads,
  • Read Length, Number Of Samples At Once, Bp Output, Cost Comparison With Sanger/ Ce, Consumable Cost Per Run)
• Chapter Seven: Intellectual Property And Litigation
  • Table 7-1: Selected Sequencing-Related Patents Assigned Or Licensed To Applied
  • Biosystems (Assignee, Title, Patent #)
• Chapter Eight: Deals
  • Table 8-1: Notable Deals In Recent Years (Companies, Date, Details
• Chapter Ten: Technologies Under Development
  • Table 10-1: First Set Of Nhgri

    "$100,000 Genome"

    Grant Awardees October 2004 (Awardee, Title, Amount, Term)
  • Table 10-2: First Set Of Nhgri

    "$1,000 Genome"

    Grant Awardees October 2004 (Awardee, Title, Amount, Term)
  • Table 10-3: Second Set Of Nhgri

    "$100,000 Genome"

    Grant Awardees August 2005 (Awardee, Title, Amount, Term)
  • Table 10-4: Second Set Of Nhgri

    "$1,000 Genome"

    Grant Awardees August 2005 (Awardee, Title, Amount, Term)
  • Table 10-5: Latest Set Of Nhgri

    "$1,000 Genome"

    Grant Awardees October 2006 (Awardee, Title, Amount, Term)
  • Table 10-6: Latest Set Of Nhgri

    "$100,000 Genome"

    Grant Awardees October 2006 (Awardee, Title, Amount, Term)
  • Table 10-7: Selected Group S Workingon Microfluidics For Dna Sequencing Applications (Number Of Channels, Read Length, Time)