The Dynamic Media, Sera and Reagent Market in Biotechnology

Publication Date	March 2007
Publisher	BCC Research
Product Type	Report
Pages	129
ISBN Number	not applicable
Product Code	BCC00004

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Summary

BCC's goal in conducting this study is to provide an overview of the media, sera and reagents used in the production of cell cultures. Although this market is rising due to increased usage, the prices of media have decreased over the last few years. The main objective of this report is to determine the market size, market leaders and factors affecting the use of media, sera and reagents used in biotechnology.

The overview of media and sera-and their composition-and the use of reagents in the field of biotechnology is also examined along with sale figures over the 5-year period from 2006 to 2011. Companies selling these products are profiled, and the factors affecting markets for these products, and how those markets are likely to change, are analyzed.

Our key objective is to present a comprehensive analysis of the current market and the future direction of media, sera and reagents used in biotechnology, with an emphasis on newer products.

Scope Of Study

This report contains:

An overview and analysis of the major types of media, sera and reagents used in biotechnology
Global market forecasts for the industry, including current and historical data as well as 5-year market projections to 2011
Review of the latest trends in technology, the latest important discoveries, and ideas and estimates for the future
A detailed analysis of important patents within the past several decades
Company profiles for the major industry players

Report Highlights

The total U.S. sales of media, sera, and reagents for biotechnology was $979 million in 2005 and almost $1.1 billion in 2006. At a compound annual growth rate (CAGR) of 8.9%, this market will grow to reach more than $1.6 billion in 2011. Sera will grow much more slowly in the market. This particular sector was worth $338.5 million in 2006 and will reach $401 million by 2011, a CAGR of just 3.5% Reagents have the greatest potential for growth, worth $382 million in 2006 and growing at a CAGR of 12.8% to reach almost $700 million by 2011.

Content

Introduction
- Study Objectives
- Reasons For Doing This Study
- Contributions To The Study
- Scope Of The Study
- Methodology
- Information Sources
- Analyst's Credentials
- Related Bcc Publications
- Bcc Online Services
- Disclaimer
Executive Summary
- Summary Table: U.S. Sales Of Media, Sera And Reagents In Biotechnology, Through 2011 ($ Millions)
- Summary Figure: U.S. Sales Of Media, Sera And Reagents In Biotechnology, 2004-2011 ($ Millions)
Overview
- Definitions
- Main Types Of Cell Cultures
  - Primary Cultures
  - Continuous Cultures
  - Culture Morphology
- Cell Culture Media
  - Basic Constituents Of Media
    - Inorganic Salts
    - Buffering Systems
    - Energy Source
    - Amino Acids
    - Vitamins
    - Proteins And Peptides
    - Fatty Acids And Lipids
    - Trace Elements
    - Antibiotics
    - Serum
  - Storage Of Media
    - Different Types Of Media
  - Serum-Free Medium
  - Serum Free Medium Composition/Constituents
    - Basal Medium
    - Lipids
    - Buffers
    - Trace Elements
    - Mechanical Stabilizers And Adhesion Factors
    - Use Of Supplements In Serum-Free Medium
    - Calcium, A Serum-Free Medium Supplement
    - Primary Functions Of Calcium In Cell Culture Systems
    - Pyridoxal And Pyridoxine, A Serum Free-Medium Supplement
    - Primary Function Of Pyridoxal And Pyridoxine In Cell Culture Systems
    - L-Glutamine, A Serum-Free Medium Supplement
    - Primary Function Of Glutamine In Cell Culture Systems
    - Stearic Acid, A Serum-Free Supplement
    - Primary Function Of Stearic Acid In Cell Culture Systems
    - Transferrin, A Serum-Free Supplement
    - Primary Functions Of Transferrin In Cell Culture Systems
    - Zinc, A Serum-Free Medium Supplement
    - Primary Functions Of Zinc In Cell Culture Systems
    - Insulin, A Serum-Free Media Supplement
    - Thrombin, A Serum-Free Supplement
    - Disadvantage Of Using Serum-Free Medium
  - Significant Protein -Free And Animal-Origin Free Products
- Serum
  - Constituents Of Serum
    - Protein And Peptides
    - Growth Factors
    - Albumin
    - Transferrin
    - Protease Inhibitors
    - Amino Acids
    - Carbohydrates
    - Fatty Acids And Lipids
    - Inorganic Salts
    - Vitamins And Minerals
    - Others
    - Infectious Agent
  - Sources Of Serum
    - Fetal Bovine Serum (Fbs)
    - Calf Serum
    - Other Animal Sera
  - Potential Problems With Serum
  - Serum Selection
- Reagents
  - Biological Response Modifiers
    - Growth Factors
    - Cytokines, Lymphokines And Interleukins
    - Interlukins
    - Colony-Stimulating Factors
    - Interferons
    - Tumor Necrosis Factor
    - Chemokines
    - Attachment Factors
    - Serum Replacers Or Serum Extenders
  - Lipids
  - Factors Affecting Cell Culture
    - Temperature
    - Ph
    - Carbon Dioxide (Co₂)
    - Humidity
    - Concentration Of The Nutrients
  - Problems Arising During Cell Culture
  - Role Of Cell Culture
- Uses Of Media And Sera And Reagents
  - Growth Factors
    - Neurotrophins
    - Epidermal Growth Factor (Egf)
    - Fibroblast Growth Factor
    - Platelet-Derived Growth Factor (Pdgf)
    - Transforming Growth Factor (Tgf)
  - Antibodies
    - Monoclonal Antibodies
    - Polyclonal Antibody
    - Nanobodies
  - Stem Cells
  - Recombinent Proteins
    - Human Recombinant Proteins
    - Granulocyte Colony-Stimulating Factor (G-Csf)
    - Tissue Plasminogen Activator (Plat Or Tpa)
    - Interferons (Ifns)
    - Insulin-Like Growth Factor 1 (Igf-1)
  - Vaccines
    - Types Of Vaccines
    - Innovative Vaccines
    - Innovative Vaccines (Continued)
Regulatory
- Fda Regulations
- Emea Regulations
- Usda Regulations
- Edqm Regulations
- Action Of Usda Against Bse
  - New Directive Regulations Regarding Bse
- Products Approved By Fda In 2004, 2005 And 2006
- New Approvals By Eu
  - New Approvals By Eu (Continued)
Industry Structure
- Media
  - Market Leaders Of Media Used In Biotechnology
- Sera
  - Market Leaders Of Sera Used In Biotechnology
- Reagents
  - Market Leaders Of Reagents Used In Biotechnology
- Factors Influencing Demand And Use
  - Increasing Use Of Serum-Free Media
  - Fda Regulations
  - Cost
  - Development Of Successful Specialty Media
  - Cell Culture Products
- Factors Affecting Production Of Serum
- Quality Control
  - The Materials
    - Media
    - Supplement
    - Vessels
  - Culture Environment
    - Temperature
    - Ph
    - Carbon Dioxide
  - Cells
    - Toxicity
    - Contamination
  - Antibiotics
- Prices
Technology
- New Developments
  - New Developments By Various Companies
    - Sigma-Adrich
    - Millipore Corporation
    - Perbio Science
    - Irvine Scientific
    - Invitrogen Corporation
    - Fisher Biosciences Unit, (Hyclone)
    - Athena Es
    - Roche Applied Sciences
    - Animal Technologies, Inc.
    - Cellgro (Mediatech)
    - Cambrex
    - Safc
    - Celliance Corporation
- Market By Product Type
  - Media
    - Liquid And Powder Media
    - Classical And Specialty Media
  - Sera
    - Bovine Sera
  - Reagents
Patents
- Patents By Product
- Patents By Company
- Trends By Emphasis
- Patents By Country
- Patents By Assignee
End Users
- Research Segment
- Production Segment
- Contract Segment
- Other Segment
- New And Improved Uses
International Aspects
- Latin America
- Europe
- Asia
  - Israel
  - India
  - China
  - Japan
- Canada
- Others
  - Russia
  - Czech Republic
  - South Korea
Company Profile
- Advanced Biotechnologies, Inc. (Abi)
- Amgen, Inc.
- Atlanta Biologicals Inc.
- Athena Es/Biological Research Faculty & Facility, Inc. (Brff)
- Becton Dickinson Co. (Bd)
- Biogen, Idec.
- Biovail Corporation
- Bioreclamation Inc.
- Cambrex Corporation
- Cell Applications, Inc.
- Centocor Inc.
- Genentech, Inc.
- Hyclone (A Subsidiary Of Thermo Fisher Scientific, Inc.)
- Irvine Scientific
- Invitrogen Corporation
- Mediatech, Inc.
- Medimmune, Inc.
- Millipore Corporation
- Peprotech, Inc.
- Pdl Biopharma, Inc.
- Quality Biological Inc.
- R&d Systems Inc.
- Roche Applied Science
- Sigma-Aldrich
- United States Biological (U.S. Biological)
Glossary
- Glossary
  - Glossary (Continued)
List Of Tables
- Summary Table: U.S. Sales Of Media, Sera And Reagents In Biotechnology, Through 2011 ($ Millions)
- Table 1 Types Of Culture Media And Their Uses
- Table 2 The Roles Of Different Inorganic Nutrients
- Table 3 Concentration Of Calcium Ions In Different Media
- Table 4 Concentration Of Vitamin B12 In Different Media
- Table 5 Concentration Of Glutamine In Different Media
- Table 6 Concentration Of Zinc In Different Media
- Table 7 Serum Containing Medium Vs Serum Free Medium
- Table 8 List Of Types Of Sera
- Table 9 Normal Range Of Concentration Of Serum Constituents
- Table 10 List Of Selected Growth Factors
- Table 11 List Of Cytokines
- Table 12 List Of Selected Interleukins
- Table 13 List Of Selected Lymphokines And Cytokines
- Table 14 List Of Selected Chemokines
- Table 15 List Of Selected Attachment Factors
- Table 16 Selected Reagents That Supplement Reduced Serum Or Serum-Free Media
- Table 17 Applications Of Monoclonal Antibodies
- Table 18 Differences Between Embryonic Stem Cells And Adult Stem Cells
- Table 19 A List Of Human Recombinant Proteins
- Table 20 Certificate Of Suitability Issued By Edqm For Albumins
- Table 21 Products Approved By Fda, 2004-2006
- Table 22 Major Suppliers Of Media Used In Biotechnology
- Table 23 Estimated Market Share In 2006 For Suppliers And Manufacturers Of Media (%)
- Table 24 Major Suppliers Of Sera Used In Biotechnology
- Table 25 Estimated Market Share In 2006 For Suppliers And Manufacturers Of Sera (%)
- Table 26 Major Suppliers Of Reagents Used In Biotechnology
- Table 27 Average Prices Of Classical Media, Through 2006 ($/L)
- Table 28 Average Prices Of Sera, Through 2006 ($/L)
- Table 29 New Products By Sigma-Aldrich
- Table 30 New Products By Irvine Scientific
- Table 31 New Products By Invitrogen Corporation
- Table 32 New Products By Hyclone
- Table 33 New Products By Roche Applied Sciences
- Table 34 U.S. Market Forecast For Sales Of Media (Serum Free And Serum Requiring), Through 2011 ($ Millions)
- Table 35 U.S. Market Forecast For Sales Of Media (Liquid And Powder), Through 2011 ($ Millions)
- Table 36 U.S. Market Forecast For Sales Of Media (Classical And Specialty), Through 2011 ($ Millions)
- Table 37 U.S. Market Forecast For Sales Of Sera, Through 2011 ($ Millions)
- Table 38 U.S. Market Forecast For Bovine Sera, Through 2011 ($ Millions)
- Table 39 U.S. Market Forecast For Reagents Used In Biotechnology, Through 2011 ($ Millions)
- Table 40 U.S. Market Forecast For Biological Response Modifiers, Through 2011 ($ Millions)
- Table 41 Number Of Significant Patents By Year, 2003-2006
- Table 42 Product-Related Patent Breakdown, 2003-2006
- Table 43 Significant Patents For Media In 2006
- Table 44 Significant Patents For Sera In 2006
- Table 45 Significant Patents For Reagents In 2006
- Table 46 Patents By Company, 2003-2006
- Table 47 Shares Of Patents Issued By Emphasis, 2003-2006
- Table 48 U.S. Patents By Country Awarded, 2003-2006
- Table 49 Trends Of Patents Issued By Country, 2003-2006
- Table 50 Shares Of U.S. Patents By Assignee
- Table 51 U.S. Expenditures Of Media, Sera And Reagents In Research Segment, Through 2011 ($ Millions)
- Table 52 U.S. Market Forecast For Media, Sera And Reagents In Production Segment, Through 2011 ($ Millions)
- Table 53 U.S. Market Forecast For Media, Sera And Reagents In Contract Segment, Through 2011 ($ Millions)
- Table 54 U.S. Market Forecast For Media, Sera And Reagents In Other Segments, Through 2011 ($ Millions)
- Table 55 Market Forecast For Media, Sera And Reagents In Biotechnology In Latin America, Through 2011 ($ Millions)
- Table 56 Market Forecast For Media, Sera And Reagents In Biotechnology In Europe, Through 2011 ($ Millions)
- Table 57 Market Forecast For Media, Sera And Reagents In Biotechnology In Asia, Through 2011 ($ Millions)
- Table 58 Market Forecast For Media, Sera And Reagents In Biotechnology In Canada, Through 2011 ($ Millions)
- Table 59 Market Forecast For Media, Sera And Reagents In Biotechnology In Other Countries, Through 2011 ($ Millions)
- Table 60 Global Market Forecast For Media, Sera And Reagents In Biotechnology, Through 2011 ($ Millions)
- Table 61 Global Market Segment Of Media, Sera And Reagents In Biotechnology, 2006 (%)
List Of Figures
- Summary Figure: U.S. Sales Of Media, Sera And Reagents In Biotechnology, 2004-2011 ($ Millions)
- Figure 1 Estimated Market Share For Suppliers And Manufacturers Of Media, 2006 (%)
- Figure 2 Estimated Market Share In 2006 For Suppliers And Manufacturers Of Sera (%)
- Figure 3 Average Prices Of Classical Media, 2003 And 2006 ($/L)
- Figure 4 Average Prices Of Sera, 2003 And 2006 ($/L)
- Figure 5 Sales Of Media (Serum-Free And Serum Requiring) In U.S. ($ Millions)
- Figure 6 Sales Of Media (Liquid And Powder) In U.S. ($ Millions)
- Figure 7 Sales Of Media (Classical And Specialty) In U.S. ($ Millions)
- Figure 8 Sales Of Sera In The U.S. 2004-2011 ($ Millions)
- Figure 9 Sales Of Bovine Sera In The U.S., 2004-2011 ($ Millions)
- Figure 10 U.S. Sales Of Reagents Used In Biotechnology, 2004-2011 ($ Millions)
- Figure 11 Sales Of Biological Response Modifiers In The U.S., 2004-2011 ($ Millions)
- Figure 12 Number Of Patents By Year, 2003-2006
- Figure 13 Product-Related Patent Breakdown, 2003-2006 (%)
- Figure 14 Shares Of Patents Issued By Emphasis, 2003-2006 (%)
- Figure 15 Number Of U.S. Patents By Assignee
- Figure 16 Shares Of U.S Patents By Assginee (%)
- Figure 17 U.S. Expenditure Of Media, Sera And Reagents In Research Segment, 2004-2011 ($ Millions)
- Figure 18 U.S. Sales Of Media, Sera And Reagents In Production Segment, 2004-2011 ($ Millions)
- Figure 19 U.S. Sales Of Media, Sera And Reagents In Contract Segment, 2004-2011 ($ Millions)
- Figure 20 U.S. Sales Of Media, Sera And Reagents In Other Segments ($ Millions)
- Figure 21 Sales Of Media, Sera And Reagents In Biotechnology In Latin America, ($ Millions)
- Figure 22 Sales Of Media, Sera And Reagents In Biotechnology In Europe, 2004-2011 ($ Millions)
- Figure 23 Sales Of Media, Sera And Reagents In Biotechnology In Asia, 2004-2011 ($ Millions)
- Figure 24 Sales Of Media, Sera And Reagents In Biotechnology In Canada, 2004-2011 ($ Millions)
- Figure 25 Sales Of Media, Sera And Reagents In Biotechnology In Other Countries, Through 2011 ($ Millions)
- Figure 26 Global Market Forecast For Media, Sera And Reagents In Biotechnology, 2004-2011 ($ Millions)
- Figure 27 Worlwide Market Segment Of Media, Sera And Reagents In Biotechnology, 2006 (%)