DNA Sequencing: Emerging Technologies and Applications

Publication Date	August 2008
Publisher	BCC Research
Product Type	Report
Pages
ISBN Number	not applicable
Product Code	BCC00202

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Summary

Study Goals And Objectives

Bcc's Goal For This Study Is To Determine The Status Of Current And Next Generation Dna Sequencing Technologies And Products And Assess Their Worldwide Growth Potential Over A Five-Year Period From 2008 To 2013. Our Particular Interest Is To Characterize And Quantify The Dna Sequencing Products Market Potential By Application, Technology, Analysis Type, Geography And End User. Sequencing Applications Market Segments That Will Provide Substantial Future Growth Opportunities For Next Generation Dna Sequencing Companies Include Research, Drug Discovery And Development, Forensics And Human Identification, Bacterial Genomics, Agricultural Genomics, Clinical Diagnostics And Personal Genomics.

Our Main Objective Is To Present A Comprehensive Discussion Of Where The State-Ofthe- Art Is In Dna Sequencing Technologies, And Assess The State Of The Sequencing Industry And The Current And Future Commercial Potential For The Key Market Segments.

Reasons For Doing The Study

The Human Genome Project (Hgp) Moved Dna Sequencing Technology To The Forefront Of Life Science Research As A Genetic Analysis Tool. The Hgp Relied Heavily On Sanger Sequencing By Capillary Electrophoresis To Decipher The Dna Sequence Of The Bases In The Human Genome. A Significant Outcome Of The Hgp Was Improvements In The Efficiency And Costs Of Dna Sequencing. During This Time Period, The Dna Sequencing Industry Consolidated, Resulting In One Dominant Company: Applied Biosystems. In 2008, In The Post-Hgp Era, New Dna Sequencing Technologies Are Emerging That Will Radically Alter The Structure Of The Industry And Open Up Substantial New Market Applications. Contributing To The Rise Of These New Sequencing Technologies Are Advances In Nanotechnology, Microfluidics, Imaging, Enzymology, And Bioinformatics. Based On These Market And Technology Dynamics, It Is Timely To Examine The Future Dna Sequencing Markets.

Ongoing Discoveries In Nanotechnology, Bioinformatics, Microfluidics, Imaging, Enzymology And Bioinformatics Are Revolutionizing Many Life Science Fields, And Providing Novel Platforms For Next Generation Dna Sequencing. At The Same Time This Is Occurring, There Is A Growing Market Demand For Analysis Of The Genomes Of Many Species And Cancers, And For Understanding The Role Of Genetic Variation Among Individuals In Disease. The Genetic Analysis Industry Seeks To Meet These Needs With Tools Such As Microarrays, Real Time Polymerase Chain Reaction (Rt-Pcr). With The Novel Next Generation Sequencing Technologies, Applications Space Vis--Vis The Other Genetic Analysis Tools Has Widened, And This Report Seeks To Understand This Trend And Its Significance For Companies Supplying Dna Sequencing Products And Services.

The Next Generation Dna Sequencing Technologies Will Change The Dynamics Of The Current Dna Sequencing Industry And Create Novel Market Opportunities. This Report Analyzes These Trends And Their Impact On The Future Markets For Dna Sequencing Technologies.

It Is Particularly Timely To Gain An Understanding Of These Industry And Technology Forces, And The Impact On The Genetic Analysis Markets.

Intended Audience

We Have Compiled A Study Of Existing And Next Generation Technologies That Will Be Commercially Important In The Major End User Segments Of Life Science Research, Drug Discovery And Development, Forensics And Human Identification, Bacterial Genomics, Agricultural Genomics, Clinical Diagnostics And Personal Genomics. We Present Both Sanger Sequencing And Next Generation, Non-Sanger Sequencing Technologies As Well As Market Growth Driving Forces, Product Formats, Market Applications, Companies And Industry Alliances, Future Market Potential And Product Sales Forecasts For The Period 2008 Through 2013. We Forecast The Use Of Sequencing Products For These End User Segments: Major Sequencing Centers, Academic Genome Centers, Government Labs, Pharmaceutical/Biotech Labs, Small To Mid-Size Labs And Sequencing Service Labs.

This Study Will Be Of Particular Interest To Life Science Research Tools Suppliers, Pharmaceutical Manufacturers, Diagnostics, Nanotechnology, And Biotechnology Companies. It Will Also Be Valuable To Companies Involved In Genome Sequencing Projects, Sequencing Centers, Manufacturers Of Microarrays, Suppliers Of Molecular Diagnostics Assays, Bioinformatics Companies, And Cancer Researchers And Clinicians.

Scope Of Report

The Study Scope Includes Dna Sequencing Technologies Likely To Be Commercialized Within The Next Five Years. Sanger And Next Generation (Non-Sanger Sequencing) Technologies Are Included. Each Technology Is Analyzed To Determine Its Market Status, Impact On Future Market Segments, And Forecasted Growth From 2008 Through 2013. Advantages And Limitations Of Each Technology Together With Market Driving Forces Are Discussed.

Bcc Examines The Sequencing Industry Structure, Strategic Industry Alliances And Acquisitions, And Sequencing Patents. The Strategies Of The Main Sanger And Next Generation Sequencing Companies Are Discussed. The Markets For Sequencing Applications, Including De Novo Whole Genome Sequencing, Re-Sequencing, Chipseq, Methylseq And Rnaseq, Are Analyzed.

Methodology

Bcc Surveyed Key Users And Producers In Each Of The Market Applications That Will Be Commercially Important During The Next Five Years: Research, Drug Discovery And Development, Forensics And Human Id, Bacterial Genomics, Agricultural Genomics, Clinical Diagnostics And Personal Genomics. Based On Our Industry Discussions And Market Analysis, We Project The Future Applications Of Sequencing Platforms And Forecast Sales Revenues For 2008 Through 2013.

The Sequencing Market Is Analyzed By Technology, Product Type, Application, Customer, Analysis Type, Geography And Genome Type, With Forecasts Of Market Demand From 2008 Through 2013. We Analyze Which Applications And Analyses Will Be Important To The Future Of Dna Sequencing, And The Customer Groups That Will Be Consumers Of The Technologies. We Also Analyze The Impact Of Other Genetic Analysis Technologies Like Microarrays On The Growth Of Sequencing.

Information Sources

Bcc Surveyed Leading Dna Sequencing, Biotechnology, And Nanotechnology Companies As Well As Core Sequencing Facilities And Laboratories To Obtain Data For This Study. Included Were Research Tools, Drug, Biotechnology And Nanotechnology Firms, And Leading Life Science Research Institutions. We Also Spoke With Leading Industry Thinkers. In Addition, We Compiled Data From Secondary Sources Including Industry, Trade, And Government.

Content

Introduction.
Study Goals And Objectives
- Reasons For Doing The Study .
Intended Audience
Scope Of Report
Methodology
Information Sources
Related Bcc Reports
Analyst Credentials
Bcc Online Services
- Disclaimer .
- Summary.
Summary Table Global Value Of Dna Sequencing, By End
- Use Application, Through 2013 ($ Millions)
Summary Figure Global Value Of Dna Sequencing, By
- End Use Application, 2006-2013 ($ Millions)
Overview
Introduction
Dna Sequencing Technologies Covered In This Report
Table Scope Of This Report
Market Potential Of Dna Sequencing Products
Table Global Value Of Dna Sequencing, By End Use
- Application, Through 2013 ($ Millions)
Table Dna Sequencing Key Growth Driving Forces
Sequencing Industry Growth
Sequencing Products
Sequencing Product Life Cycle Status
Table Life Cycle Status Of Next Generation
Sequencing Platforms
Commercial Status
Sequencing Industry
Table Company Positioning By Sequencing Technology
Dna Sequencing Technologies
Genetic Analysis
Figure Dna, Mrna And Genetic Variation
Genetic Analysis
Table Scope Of Key Genetic Analysis Technologies
History Of Dna Sequencing
Table Genetic Analysis History
History Of Dna Sequencing
History Of Dna Sequencing
Figure Sequencing Throughput Trend
Figure Human Genome Sequencing Cost Trend
Figure $1,000 Genome Product Space
Overview Of Sequencing Technologies
Figure Key Dna Sequencing Technologies
Overview Of Sequencing
Sequencing Workflow
Figure Dna Sequencing Platform Workflow Steps
Sequencing Workflow
Sanger Sequencing
Sanger Sequencing Technology
Figure Ddntp Chemical Structure
Figure Sanger Sequencing Workflow
- Sanger Sequencing Technology (Continued)
Sanger Sequencing Costs
Figure Cost Breakdown For Sequencing A Single
Human Genome, Using 2005 Sanger Sequencer
- Technology (%)
Table Limitations Of Sanger Sequencing Technology
Table Improvements In Sanger Sequencing
Technology
Next Generation Sequencing Technologies
Figure Next Generation Sequencing Technologies
Table Commercial In-Vitro Amplification Ngs
Technologies
Figure Schematic Comparison Of Sbs And Sbl
Sequencing Platforms
Figure Sequencing By Synthesis: Reversible
Terminator Reaction
Pyrosequencing By Synthesis
Figure Sequencing By Synthesis: Pyrosequencing
Reaction
Sequencing By Ligation
- Sample Preparation
- Sequencing Reaction
Figure Schematic Of Solid Sequencing By Ligation
- Cycle
- Cycle
- Cycles To
- Decoding
Figure Decoding Solid Color Data
Single Molecule Sequencing
- Single Molecule Sequencing By Synthesis
Figure Single Molecule Sequencing By Synthesis
- Nanopore Sequencing
- Nanopore Sequencing (Continued)
Figure Nanopore Sequencing Workflow And
Technology Approaches
Sequencing Technology Platforms Compared
Table Key Performance Metrics For Sequencing
Technologies
Table Comparison Of Selected Dna Sequencing
Platforms
- Sequencing Technology Platforms (Continued)
Sequencing Product Life Cycle
Table Life Cycle Of Dna Sequencing Technologies
Sequencing Instrument Cumulative Installed
- Base
Figure Global Cumulative Installed Base Of Dna
- Sequencers, Through 2008 (%)
Future Performance Of Next Generation
Sequencers
Table Future Performance Of Next Generation
Sequencing Platforms
Sequence Read Length
Table Read Lengths For Selected Sequencing
Platforms
Sequencer Performance Space
Figure Sequencing Competitive Market Space
End User Switching
Paired End Reads
Table Strengths And Limitations Of Paired End Reads
Dna Polymerases
Technology Challenges For Ngs Platforms
Table Technology Challenges For Next Generation
Sequencing
- Technology Challenges For (Continued)
Dna Sequencing Applications
Introduction
Research And Drug Discovery Applications
Introduction
Table Sequencing Applications
Table De Novo Versus Re-Sequencing Requirements
De Novo Whole Genome Sequencing
- De Novo Human Whole Genome Sequencing
- De Novo Microbial Whole Genome Sequencing
Table Case Study: Neanderthal Dna Sequencing
Resequencing
- Whole Genome Resequencing (Genome-Wide Association
- Studies Or Loci Discovery)
Figure Single Sequencer, Whole Genome Throughput
- Trends 1975-2015
- Targeted Resequencing
Tag Sequencing: Ngs And Microarrays Seek Same
Applications Space
Table Emerging Genetic Analysis Applications
- Chromatin Immunoprecipitation Applications
Table Comparison Of Sequencing With Microarrays
For Chip Applications
- Gene Expression Analysis
Table Next Generation Sequencing Versus
Microarrays In The Gene Expression Analysis Space
- Dna Methylation Analysis
- Dna Mutation Studies
- Complementary Sequencing And Microarray Platforms
- Drive Market Growth
Diagnostics And Drug Discovery
- Diagnostics And Drug Discovery (Continued)
Personal Genomics
Figure Genetic Analysis Cost/Information Content
- Trends
Dna Sequencing Initiatives
Introduction
Nhgri $100,000 Genome And $1,000 Genome Projects
Table Nhgri Grants For Next Generation Sequencing
- To Commercial Entities, 2004-2007 ($ Million)
Figure Nhgri $100,000 And $1,000 Genome Project
- Cumulative Funding By Technology, 2004-2007 ($98
- Million) (%)
- Figure Nhgri Annual Funding By Technology, 2004-2007
- Figure Nhgri Funding Of $100,000 And $1,000 Programs,
- 2004-2007
Genomics Projects Overview And Status
Table Important Sequencing Research Initiatives
Genome Sequencing Projects
Functional Genomics In Norway
Personal Genome Project
Archon Prize In Genomics
Medical Sequencing Projects
Mapped Autosomal Mendelian Disorders
Allelic Spectrum In Common Disease Program
Clinseq
Cancer Sequencing Projects
- Tumor Sequencing Project (Tsp)
The Cancer Genome Atlas
Microbial Sequencing Projects
Human Microbiome Project
Microbial Genome Sequencing Project
Marine Microbial Genome Sequencing Project
Fungal Genome Initiative
Pathogen Sequencing Program
Genomic Encyclopedia Of Bacteria And Archaea
- (Geba)
Metagenomics Of The Human Intestinal Tract
- (Metahit)
Gut Microbiome Initiative
Genome Variation Projects
- ,000 Genomes Project
Resequencing Technology Program
Human Genome Structural Variation Project
Yanhuang Project
Agricultural Genomics
National Plant Genome Initiative
Epigenomics Sequencing Projects
Roadmap Epigenomics Program
- Encyclopedia Of Dna Elements (Encode)
Impact Of Sequencing Projects
- Figure Growth In Base Pairs Depositied In Genbank,
- 1986-2006
Dna Sequencing Industry Structure
Industry Structure Analysis
- Figure Dna Sequencing Industry Structure, 1995-2005
Industry Structure Analysis
- Figure Dna Sequencing Industry Structure, Post 2005
Table Dna Sequencing Industry Transition
The Role Of Early Adaptors
Sequencing Instrument Competitor Positioning
Table Company Positioning By Sequencing
Technology
Competitor Market Shares
- Figure 2008 Estimated Competitor Market Share:
Sequencing Instruments And Reagents (Total
- Market: $862. Million) (%)
- Figure 2008 Estimated Competitor Market Share:
Sanger Sequencing Instruments And Reagents (Total
- Market: $557. Million) (%)
Figure 2008 Estimated Competitor Market Share: Next
Generation Sequencing Instruments And Reagents
- (Total Market $305. Million) (%)
Industry Acquisitions And Strategic Alliances
- Table Sequencing Industry Acquisitions, 2006-2008
Industry Acquisitions And
- Table Sequencing Industry Strategic Alliances, 2005-
- 2008
Reagents Supply Alliances
Personal Genomics Market Segment
Table Personal Genomics Key Competitors
Table Personal Genomics Competitor Strategies
Personal Genomics Market Segment
Figure Personal Genomics Competitive Positioning
Dna Sequencing End Users
Table Dna Sequencing End User Market Segments
Major Sequencing Centers
Table Major Sequencing Centers
- Major Sequencing Centers (Continued)
Figure Major Sequencing Centers Share Of The
- Genome Sequencing Projects Market, 2008 (%)
Figure Washington University Adoption Of Next
- Generation Sequencers, 2007 And 2008
Large Core Sequencing Centers
Table Examples Of Large Core Sequencing Centers
Small To Mid-Size Laboratories
Sequencing Service Laboratories
- Sequencing Service Laboratories (Continued)
Dna Sequencing Markets
Growth Driving Forces
Table Dna Sequencing Key Growth Driving Forces
Growth Driving Forces
- Figure 2008 Sequencing Funding By Agency (%)
Growth Driving Forces
Figure Eukaryotic Sequencing Paradigm
Genetic Analysis Markets
- Genetic Analysis Markets (Continued)
Table Global Value Of Genetic Analysis Market, By
- Analysis Type, Through 2013 ($ Millions)
Figure Snp Genotyping Market
Dna Sequencing Products Markets
Dna Sequencing Markets By Product Type
Table Global Value Of Dna Sequencing Market, By
- Product Type, Through 2013 ($ Millions)
Dna Sequencing Markets By Sanger And Next
Generation Formats
- Dna Sequencing Markets By Sanger (Continued)
- Table Global Value Of Dna Sequencing Instruments,
By Sanger And Next Generation Formats, Through
- 2013 ($ Millions)
Table Global Value Of Dna Sequencing Consumables
- Market, By Sanger And Next Generation Formats,
- Through 2013 ($ Millions)
Dna Sequencing Markets By End User
- Table Global Value Of Dna Sequencing, By Customer,
- Through 2013 ($ Millions)
- Dna Sequencing Markets By (Continued)
Table Global Value Of Sanger Sequencing, By
- Customer, Through 2013 ($ Millions)
- Table Global Value Of Next Generation Sequencing,
- By Customer, Through 2013 ($ Millions)
Dna Sequencing Markets By Technology
Table Global Value Of Dna Sequencing Market, By
- Technology, Through 2013 ($ Millions)
Dna Sequencing Markets By End User
Application
Table Global Value Of Dna Sequencing, By End Use
- Application, Through 2013 ($ Millions)
- Research And Drug Discovery And Development
- Forensic And Human Id
- Bacterial Genomics
- Agricultural Genomics
- Clinical Diagnostics
- Personal Genomics
- Personal Genomics (Continued)
- Other
- Table Global Value Of Next Generation Sequencing,
- By End Use Application, Through 2013 ($ Millions)
- Other (Continued)
Table Global Value Of Sanger Sequencing, By End-Use
- Application, Through 2013 ($ Millions)
Dna Sequencing Markets By Genome Type
- Table Global Value Of Sequencing, By Genome,
- Through 2013 ($ Millions)
Dna Sequencing Markets By Analysis Type
Table Global Value Of Dna Sequencing, By Analysis
- Type, Through 2013 ($ Millions)
- Table Global Value Of Next Generation Sequencing,
- By Analysis Type, Through 2013 ($ Millions)
Table Global Value Of Sanger Sequencing, By
- Analysis Type, Through 2013 ($ Millions)
Dna Sequencing Markets By Geography
Table Global Value Of Dna Sequencing Products, By
- Geographical Market, Through 2013 ($ Millions)
- Table Global Value Of Sanger Sequencing Products,
- By Geographical Market, Through 2013 ($ Millions)
Table Global Value Of Next Generation Sequencing
- Products, By Geographical Market, Through 2013
- ($ Millions)
- Dna Sequencing Markets By Geography (Continued)
Dna Sequencing Patent Status
Recent Patent Activity In Next Generation Dna
Sequencing
Table Recent Activity In Next Generation
Sequencing Patents
Sequencing By Synthesis
Single Molecule Sequencing
Nanopore Sequencing
Polony Sequencing
Nucleotide Modifications And Analogs
Dna Polymerases
Paired End Inventions
Other Methods
Patent Position Of Sequencing Competitors
Figure Worldwide Sequencing Patent Applications By
Company, 2001 To Present
Technology Distribution Of Next Generation
Sequencing Patents
Figure Worldwide Next Generation Sequencing
Patent Applications, By Technology, 2001-2008 (Number
- Of Patent Applications)
Geographical Distribution Of Sequencingrelated
Patents
Figure Worldwide Sequencing-Related Patent
Applications, By Geography, 2001-2008 (Number Of
- Patent Applications)
Sequencing Litigation Status
Table Sequencing Ip Litigation Status
Affymetrix Versus Illumina
Applied Biosystems Versus Solexa
Beckman Coulter Versus Applied Biosystems
Enzo Biochem Versus Caltech/Abi
Intellectual Property Position Of Selected
Sequencing Companies
Applied Biosystems
- Li-Cor Biosciences
Helicos Biosciences
Illumina
Intelligent Biosystems
Pacific Biosciences
Visigen Biotechnologies
Company Profiles
- 23andme
Affymetrix Inc
Agilent Technologies, Inc
Applied Biosystems
Applied Biosystems
Base4innovation Ltd
Beckman Coulter
Bionanomatrix
Cartesian Gridspeed
- Clinical Data Corporation (Cogenics Division)
Complete Genomics, Inc
Danaher Motion
Decodeme
Deltadot Ltd
Eurofins Medigenomix Gmbh
Expression Analysis, Inc
Fasteris Sa
Foundation For Applied Molecular Evolution
Gatc Biotech Ag
Ge Healthcare
Genome Corp
- Genome Diagnostics B.
Genome Diagnostics, Inc
Genomequest
Genovo Gmbh
Helicos Biosciences Corporation
Helix Health
Illumina, Inc
- Illumina, Inc.
Interna Genomics Bv
Invitrogen
Invitrogen
Ip Genesis Inc
- Knome, Inc
Lasergen, Inc
- Li-Cor Biosciences
Lightspeed Genomics
Lingvitae As
Microchip Biotechnologies, Inc
Mwg Biotech Ag
Nabsys, Inc
Navigenics
Nanophotonics Biosciences Inc
Network Biosystems
Pacific Biosciences
Population Genetics Technologies, Ltd
Population Genetics
Reveo Inc
Roche Life Sciences
Roche Life Sciences
Seirad, Inc
Sequenom
Sequenom
Seqwright
Smartgene
Sorenson Genomics
- U.S. Genomics
Vicgene Biotechnology
Visigen Biotechnologies, Inc
- -Prize Foundation
Zs Genetics
Zs Genetics
List Of Tables
Summary Table Global Value Of Dna Sequencing, By End
- Use Application, Through 2013 ($ Millions).
Table Scope Of This Report
Table Global Value Of Dna Sequencing, By End Use
- Application, Through 2013 ($ Millions)
Table Dna Sequencing Key Growth Driving Forces
Table Life Cycle Status Of Next Generation Sequencing
Platforms
Table Company Positioning By Sequencing Technology
Table Scope Of Key Genetic Analysis Technologies
Table Genetic Analysis History
Table Limitations Of Sanger Sequencing Technology
Table Improvements In Sanger Sequencing Technology
Table Commercial In-Vitro Amplification Ngs
Technologies
Table Key Performance Metrics For Sequencing
Technologies
Table Comparison Of Selected Dna Sequencing
Platforms
Table Life Cycle Of Dna Sequencing Technologies
Table Future Performance Of Next Generation
Sequencing Platforms
Table Read Lengths For Selected Sequencing
Platforms
Table Strengths And Limitations Of Paired End Reads
Table Technology Challenges For Next Generation
Sequencing
Table Sequencing Applications
Table De Novo Versus Re-Sequencing Requirements
Table Case Study: Neanderthal Dna Sequencing
Table Emerging Genetic Analysis Applications
Table Comparison Of Sequencing With Microarrays For
Chip Applications
Table Next Generation Sequencing Versus Microarrays
In The Gene Expression Analysis Space
Table Nhgri Grants For Next Generation Sequencing To
- Commercial Entities, 2004-2007 ($ Million)
Table Important Sequencing Research Initiatives
Table Dna Sequencing Industry Transition
Table Company Positioning By Sequencing Technology
- Table Sequencing Industry Acquisitions, 2006-2008
- Table Sequencing Industry Strategic Alliances, 2005-
- 2008
Table Personal Genomics Key Competitors
Table Personal Genomics Competitor Strategies
Table Dna Sequencing End User Market Segments
Table Major Sequencing Centers
Table Examples Of Large Core Sequencing Centers
Table Dna Sequencing Key Growth Driving Forces
Table Global Value Of Genetic Analysis Market, By
- Analysis Type, Through 2013 ($ Millions)
Table Global Value Of Dna Sequencing Market, By
- Product Type, Through 2013 ($ Millions)
Table Global Value Of Dna Sequencing Instruments, By
- Sanger And Next Generation Formats, Through 2013
- ($ Millions)
Table Global Value Of Dna Sequencing Consumables
- Market, By Sanger And Next Generation Formats,
- Through 2013 ($ Millions)
- Table Global Value Of Dna Sequencing, By Customer,
- Through 2013 ($ Millions)
Table Global Value Of Sanger Sequencing, By
- Customer, Through 2013 ($ Millions)
Table Global Value Of Next Generation Sequencing, By
- Customer, Through 2013 ($ Millions)
Table Global Value Of Dna Sequencing Market, By
- Technology, Through 2013 ($ Millions)
Table Global Value Of Dna Sequencing, By End Use
- Application, Through 2013 ($ Millions)
Table Global Value Of Next Generation Sequencing, By
- End Use Application, Through 2013 ($ Millions)
Table Global Value Of Sanger Sequencing, By End-Use
- Application, Through 2013 ($ Millions)
Table Global Value Of Sequencing, By Genome, Through
- 2013 ($ Millions)
Table Global Value Of Dna Sequencing, By Analysis
- Type, Through 2013 ($ Millions)
Table Global Value Of Next Generation Sequencing, By
- Analysis Type, Through 2013 ($ Millions)
Table Global Value Of Sanger Sequencing, By Analysis
- Type, Through 2013 ($ Millions)
Table Global Value Of Dna Sequencing Products, By
- Geographical Market, Through 2013 ($ Millions)
Table Global Value Of Sanger Sequencing Products, By
- Geographical Market, Through 2013 ($ Millions)
Table Global Value Of Next Generation Sequencing
- Products, By Geographical Market, Through 2013
- ($ Millions)
Table Recent Activity In Next Generation Sequencing
Patents
Table Sequencing Ip Litigation Status
List Of Figures
Summary Figure Global Value Of Dna Sequencing, By End
- Use Application, 2006-2013 ($ Millions)
Figure Dna, Mrna And Genetic Variation
Figure Sequencing Throughput Trend
Figure Human Genome Sequencing Cost Trend
Figure $1,000 Genome Product Space
Figure Key Dna Sequencing Technologies
Figure Dna Sequencing Platform Workflow Steps
Figure Ddntp Chemical Structure
Figure Sanger Sequencing Workflow
Figure Cost Breakdown For Sequencing A Single Human
- Genome, Using 2005 Sanger Sequencer Technology (%)
Figure Next Generation Sequencing Technologies
Figure Schematic Comparison Of Sbs And Sbl
Sequencing Platforms
Figure Sequencing By Synthesis: Reversible
Terminator Reaction
Figure Sequencing By Synthesis: Pyrosequencing
Reaction
Figure Schematic Of Solid Sequencing By Ligation
Figure Decoding Solid Color Data
Figure Single Molecule Sequencing By Synthesis
Figure Nanopore Sequencing Workflow And
Technology Approaches
Figure Global Cumulative Installed Base Of Dna
- Sequencers, Through 2008 (%)
Figure Sequencing Competitive Market Space
Figure Single Sequencer, Whole Genome Throughput
- Trends 1975-2015
Figure Genetic Analysis Cost/Information Content
- Trends
Figure Nhgri $100,000 And $1,000 Genome Project
- Cumulative Funding By Technology, 2004-2007 ($98
- Million) (%)
- Figure Nhgri Annual Funding By Technology, 2004-2007
- Figure Nhgri Funding Of $100,000 And $1,000 Programs,
- 2004-2007
- Figure Growth In Base Pairs Depositied In Genbank, 1986-
- 2006
- Figure Dna Sequencing Industry Structure, 1995-2005
- Figure Dna Sequencing Industry Structure, Post 2005
- Figure 2008 Estimated Competitor Market Share:
- Sequencing Instruments And Reagents (Total Market:
- $862. Million) (%)
- Figure 2008 Estimated Competitor Market Share:
Sanger Sequencing Instruments And Reagents (Total
- Market: $557. Million) (%)
Figure 2008 Estimated Competitor Market Share: Next
Generation Sequencing Instruments And Reagents
- (Total Market $305. Million) (%)
Figure Personal Genomics Competitive Positioning
Figure Major Sequencing Centers Share Of The Genome
- Sequencing Projects Market, 2008 (%)
Figure Washington University Adoption Of Next
- Generation Sequencers, 2007 And 2008
- Figure 2008 Sequencing Funding By Agency (%)
Figure Eukaryotic Sequencing Paradigm
Figure Snp Genotyping Market
Figure Worldwide Sequencing Patent Applications By
Company, 2001 To Present
Figure Worldwide Next Generation Sequencing Patent
Applications, By Technology, 2001-2008 (Number Of
- Patent Applications)
Figure Worldwide Sequencing-Related Patent
Applications, By Geography, 2001-2008 (Number Of Patent
- Applications)