DePuy Medical Device Company Intelligence Report

Publication Date	December 2007
Publisher	Espicom
Product Type	Report
Pages	70
ISBN Number	not applicable
Product Code	ESP00573

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Summary

Headquartered in Warsaw, Indiana, USA, Johnson & Johnson's DePuy subsidiary is one of the world's leading orthopaedic companies and the oldest manufacturer of orthopaedic implants in the US. DePuy's products are primarily used by orthopaedic specialists and spinal neurosurgeons to treat patients with musculoskeletal conditions resulting from degenerative diseases, deformities, trauma and sports-related injuries.

DePuy consists of the following companies:-

DePuy Orthopaedics - a leading manufacturer of orthopaedic devices, including hip, knee and extremity replacements, bone cement, trauma, orthobiologics and operating room products. DePuy Orthopaedics is based in DePuy's headquarters in Warsaw. The company includes the Trauma & Extremities Group, which offers reconstructive extremity products and the trauma products previously marketed by the former DePuy ACE business. The unit was expanded by the acquisition of Hand Innovations in 2006, a manufacturer of fracture fixation products for upper extremities.

DePuy Mitek - a manufacturer of devices for surgery, focusing on sports medicine and reconstruction, including suture anchoring implants for tissue reattachment. The company includes Future Medical Systems, a French company that offers arthroscopic fluid management systems, acquired in 2006. In addition, Mitek markets the VAPR System for soft tissue removal and modification through an agreement with Gyrus. DePuy Mitek has its headquarters in Norwood, Massachusetts, USA.

Codman & Shurtleff (Codman) - headquartered in Raynham, Massachusetts, USA. Provides products for the surgical treatment of central nervous system disorders, including hydrocephalic shunt valve systems. The company also offers surgical instruments and Synergetics USA's bipolar electrosurgical systems.

DePuy Spine - manufactures implants and technologies for the treatment of cervical, thoracic, lumbar and sacral spinal pathologies. DePuy Spine is headquartered in Raynham, Massachusetts. The company was called DePuy AcroMed until October 2003.

DePuy International - represents the products of DePuy in all markets outside North America. The company is headquartered in Leeds, UK.

In the US, DePuy has manufacturing facilities in Indiana, Massachusetts, California and Florida. In the international region, the company has production facilities in France, Ireland, Switzerland and the UK.

Content

Executive Summary
- Overview
  - Recent Key Events
    - Operating Review
  - Fig 1: DePuy Sales, 2004-2006 (US$ million)
- Strategic Focus
  - Orthopaedics
  - DePuy Mitek
  - DePuy Spine
Product Portfolio and R&d
- Fig 2: Global Orthopaedic Market Shares, 2006
- Fig 3: Global Orthopaedic Market by Product, 2006*
- Recent Product Approvals
Orthopaedic Products
- Fig 4: Global Reconstruction Market Shares, 2006*
- Fig 5: Global Reconstruction Market by Product, 2006*
  - Computer-Assisted Surgery - iOrthopaedics
  - Hip Systems
  - Hip Resurfacing and Bone Conservation
- Asr Hip Resurfacing System
- Proxima
- Microhip Instruments
  - Hip Joint Reconstruction Components
- Anatomic Medullary Locking (AML) Total Hip System
- Corail Hip Systems
- S-ROM Modular Hip System
- Charnley Hip and Elite plus
  - Acetabular Bearings
- Marathon Cross-Linked Polyethylene
- Duraloc Acetabular Cup System
- Ultamet Metal-on-Metal Articulation
- Pinnacle Acetabular Cup System
  - Knee Systems
  - Mobile-Bearing Knees
  - Preservation Uni-Compartmental Knee
  - Orthogenesis Limb Preservation System
  - Extremities
  - Shoulder Systems
  - Agility Total Ankle System
  - Agility LP Total Ankle Replacement
  - Trauma Products
- Fig 6: Global Fixation Market, 2006*
  - Hip Fracture Products
  - Polyax Locked Plating System
  - Plates and Screws
- Hand Innovations' Products
  - VersaNail Platform
  - ACE-Fischer Fixator
  - OrthoSorb Resorbable Pins
- DePuy
  - Cement and Accessories
Spinal Products
- Spinal Market Dynamics
Fig 7: Global Spinal Market Shares, 2006*
- Artificial Spinal Discs
- Discover Cervical Disc
Cervical Disc Replacement Products - Competitive Landscape
- Charit Artificial Disc
Published Clinical Study Results
US Reimbursement Issues and Market Dynamics
- Minimally-invasive Spinal Surgery
- Expenium Spine Products
- Expedium SFX Cross Connector System
- Expedium 6 35
- Aegis Anterior Lumbar Plate System
- VertiGraft VG2 TLIF Allograft
Orthobiologics
- Fig 8: Global Orthobiologics Market, 2006*
  - Cellect
  - Optium
  - Healos
  - Symphony II PCS
  - Symphony Graft Delivery System (GDS)
  - Conduit TCP
Sports Injury Products
- Fig 9: Global Arthroscopy Products Market, 2006*
  - Shoulder Products
  - Lupine BR and Bioknotless BR
  - Versalok
  - Expressew II Flexible Suture Passer
  - CHIA PERCPASSER
  - Quickanchor plus with Orthocord
  - Knee Products
  - Orthovisc
  - Milagro Interference Screw
  - Future Medical Systems Products
  - Bipolar Arthroscopy
Neurosurgery Products
- Hemedex QFlow 500 Perfusion Probe and Bowman Perfusion Monitor
- Csf Shunting and Drainage
- Codman Microsensor ICP Monitoring System
- Sundt Slim-Line System
- Cranial Access and Closure Products
- Duraform Dural Graft Implant
- Ethisorb Dura Patch
- Bioplate Neurosurgery Fixation System
- Craniosorb Absorbable Fixation System
- Bipolar Electrosurgery Products
- Codman Malis CMC-III Bipolar Electrosurgical System
- General Instruments
- Drug Delivery
- DePuy
Research and Development
- Hip Projects
- Compel
- Spinal Projects
- Cartilage Autograft Implantation System
- Knee Projects
- Research Agreements
- Axial Biotech
- Archus Orthopedics
- University of Leeds
International Activities
- Revenue by Geographic Location, 2004-2006 (US$ million)
- Fig 10: Sales by Region, 2006
Operating Activities
- United States
- Europe
- France
- Ireland
- Switzerland
- United Kingdom
- China
- Africa
Major Manufacturing Locations
Appendices
- Appendix 1 - Key Corporate Events
- Appendix 2 - Mergers and Acquisitions
  - Key Mergers and Acquisitions
    - Disc-O-Tech Medical Technologies' Vertebral Compression Fracture Assets
    - Future Medical Systems SA
    - Hand Innovations LLC
    - OrthoMedics
    - Expressew and Latte Suture Passing Systems
    - Micomed Ortho's Spinal Assets
    - Bright Group's Minimally-invasive Spinal Technology
    - Link Spine Group
    - Orquest
    - Innovasive Devices
    - AcroMed
    - Landanger-Camus
    - CMW
    - ACE Medical
- Appendix 3 - Minority Investments
  - Biomerix Corporation
- Appendix 4 - Divestitures
  - Casting and Splinting Business
  - DePuy OrthoTech
- Appendix 5 - Agreements
  - Key Agreements
    - Synergetics USA
    - Anika Therapeutics
  - DePuy
    - Biopharm
    - Biomet
    - Osteotech and LifeNet
    - FzioMed
    - Harvest Technologies
    - DJO
    - BrainLAB
    - Gyrus
    - Bioplate
    - Biedermann Motech GmbH
- Appendix 6 - Litigation
  - US Subpoenas and Class Actions
  - Medtronic
  - Charit Artificial Disc Lawsuits
  - Allez Spine
  - Alphatec Holdings
Index of Tables
- Recent Key Events
- Recent Product Approvals
- Cervical Disc Replacement Products - Competitive Landscape
- Revenue by Geographic Location, 2004-2006 (US$ million)
- Major Manufacturing Locations
- Key Mergers and Acquisitions
- Key Agreements
Index of Charts
- Fig 1: DePuy Sales, 2004-2006 (US$ million)
- Fig 2: Global Orthopaedic Market Shares, 2006
- Fig 3: Global Orthopaedic Market by Product, 2006*
- Fig 4: Global Reconstruction Market Shares, 2006*
- Fig 5: Global Reconstruction Market by Product, 2006*
- Fig 6: Global Fixation Market, 2006*
- Fig 7: Global Spinal Market Shares, 2006*
- Fig 8: Global Orthobiologics Market, 2006*
- Fig 9: Global Arthroscopy Products Market, 2006*
- Fig 10: Sales by Region, 2006