Innovations in Medical Imaging

Content

• Executive Summary
  • Introduction
  • Current issues in medical imaging & recent breakthroughs
  • Challenges, opportunities & regulations
  • Market, trends & future directions
• Chapter 1 Introduction
  • What does medical imaging encompass?
  • Anatomical & functional imaging
  • Why is medical imaging of value to the pharmaceutical industry?
  • Applications of medical imaging in drug R&D
  • Leading imaging modalities
  • X-Ray
  • Computed tomography
  • Magnetic resonance imaging
  • Functional MRI
  • Optical near-infrared fluorescence imaging
  • Ultrasound
  • Nuclear medicine
  • Positron Emission Tomography
  • Single Photon Emission Computed Tomography
  • Other imaging modalities
  • Video imaging
  • Comparison of imaging modalities: in vivo & ex vivo applications
  • Advantages & disadvantages of imaging modalities
  • Therapeutic applications
  • Cancer
  • Breast cancer
  • Colorectal cancer
  • Cardiovascular disease
  • Coronary artery disease
  • Stroke
  • Other cardiovascular conditions
  • Gastrointestinal conditions
  • Orthopedics & osteoporosis
  • CNS and thoracic trauma
  • Therapeutic conclusions
• Chapter 2 Current issues in medical imaging & recent breakthroughs
  • Pre-processing & post-processing issues
  • Artifacts
  • Noise
  • Noise & artifact reduction
  • Raw data acquisition & image reconstruction
  • Image enhancement & portioning
  • Conclusions on imaging issues
  • Breakthroughs in medical imaging
  • Novel imaging agents
  • CT imaging agents
  • MRI imaging agents
  • Ultrasound imaging agents
  • PET & SPECT imaging agents
  • Imaging agent conclusions
  • Novel scintillator & detectors
  • Multimodality imaging devices
  • SPECT-CT & PET-CT hybrids
  • Spectral CT
  • High field MRI
  • Conclusions on imaging breakthroughs
• Chapter 3 Challenges, opportunities & regulations
  • Geographical challenges & opportunities
  • US market growth & legislative impact
  • International markets and changing dynamics
  • Urbanization and rise of the emerging markets
  • Patient demographics: therapeutic dynamics
  • Technical Challenges & Opportunities
  • Molecular imaging
  • Molecular imaging probes
  • Regulatory support
  • Molecular imaging consortia
  • Imaging task forces
  • Targeted and multifunctional imaging agents
  • Nanotechnology
  • Nano-enabled delivery
  • Nano imaging materials
  • Targeted contrast agents
  • Multifunctional imaging agents
  • Novel imaging modalities
  • Magnetic Particle Imaging
  • PET-MRI
  • Real-time whole animal imaging
  • Multi-spectral opto-acoustic tomography
  • Computer assisted imaging & virtual surgery
  • Virtual surgery
  • Breakthrough conclusions
  • Reimbursement & regulations
  • Overall conclusions
• Chapter 4 Market trends & future directions
  • The medical imaging market
  • Leading manufacturers of medical imaging equipment
  • Leading healthcare companies
  • GE Healthcare, New York, US
  • Hitachi Medical Corporation, Tokyo, Japan
  • Philips Medical Systems, Amsterdam, The Netherlands
  • Siemens Medical Solutions, Berlin & Munich, Germany
  • Toshiba Medical Systems Corporation, Tokyo, Japan
  • M&A activity
  • Recent market trends
  • Global trends in medical imaging
  • Technological trends in imaging equipment
  • Imaging agents & nanotechnology
  • Image-guided radiation therapy and patient selection
  • Future directions
  • Molecular imaging & diagnostics
  • Medical imaging informatics and networking
  • Medical imaging and virtual reality
  • Summary & overall conclusions
• Chapter 5 Appendices
  • Primary research methodology
  • Companies involved in medical imaging
  • Glossary
  • Acknowledgements
  • Index
  • Bibliography & Endnotes
• List of Figures
  • Figure 1.1: Medical imaging uses a spectrum of wavelengths
  • Figure 1.2: Medical imaging technologies
  • Figure 1.3: Imaging techniques and their uses
  • Figure 1.4: Medical imaging in the drug discovery & development process
  • Figure 1.5: X-ray of a skull a) anterior-posterior and b) lateral view
  • Figure 1.6: Computed tomography of the head a) coronal section and b) sagittal section
  • Figure 1.7: X-ray imagers
  • Figure 1.8: Evolution of CT imaging
  • Figure 1.9: Magnetic resonance imaging of the head
  • Figure 1.10: Functional magnetic resonance imaging of the brain
  • Figure 1.11: Multispectral imaging of the arm (700-900 nm range)
  • Figure 1.12: Ultrasound image of a baby in-utero
  • Figure 1.13: Principles of PET imaging
  • Figure 1.14: Fused PET/CT image of anatomy and function
  • Figure 1.15: SPECT detection
  • Figure 1.16: video imaging
  • Figure 1.17: Therapeutic application of medical imaging
  • Figure 1.18: Therapeutic applications of medical imaging
  • Figure 2.19: Medical imaging workflow
  • Figure 2.20: CT imaging artifacts
  • Figure 2.21: US imaging artifacts
  • Figure 2.22: US imaging artifacts
  • Figure 2.23: Recent technological breakthroughs in medical imaging
  • Figure 2.24: New scintillator materials
  • Figure 2.25: Opportunities in PET & SPECT for better energy resolution
  • Figure 2.26: Advances collimators focus and maximize SPECT-CT
  • Figure 2.27: Schematic of Spectral CT technology
  • Figure 2.28: Diffusion MRI - CNS
  • Figure 3.29: Historical and future outlook of MR/CT revenues in the US (1997-2011)
  • Figure 3.30: Global Population (2008)
  • Figure 3.31: Population over 60: world and developed regions (1950-2050)
  • Figure 3.32: Projected global deaths for selected conditions (2005-2030)
  • Figure 3.33: Application of molecular imaging
  • Figure 3.34: Delivery platforms for contrast agent
  • Figure 3.35: Multifunctional agents
  • Figure 3.36: Schematic of MPI technology
  • Figure 3.37: IVIS Kinetic images in small animal models
  • Figure 3.38: Real-time whole body optical imaging of Zebrafish
• List of Tables
  • Table 1.1: Examples of image-related biomarkers with application in a variety of disease areas
  • Table 1.2: Common PET positron-emitting tracer isotopes
  • Table 1.3: Common SPECT radionuclides
  • Table 1.4: Ex vivo imaging modalities
  • Table 1.5: In vivo imaging modalities
  • Table 1.6: Advantages & disadvantages of imaging modalities
  • Table 3.7: Impact of American Recovery & Reinvestment Act (ARRA) on healthcare & medical imaging
  • Table 3.8: Recent impact of investment & regulation on international healthcare & medical imaging markets
  • Table 3.9: Typical effective radiation doses for medical imaging procedures
  • Table 3.10: Leading manufacturers of small animal imaging equipment and probes
  • Table 4.11: The medical imaging market ??