Bladder Cancer Drug Pipeline Update 2007

Publication Date	May 2007
Publisher	Bioseeker
Product Type	CD-ROM
Pages
ISBN Number	not applicable
Product Code	BSK00022

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Summary

According to the American Cancer Society, bladder cancer is the 6th most common cancer in the U.S. Bladder cancer occurs among both men and women. When found and treated early, the 5 year survival rate is 94%.

There are today no less than 54 therapeutics targeting bladder cancer, from early preclinical to marketed drugs. Bladder Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 38 different targets. These targets are further categorized on the CD-ROM by 20 classifications of molecular function and their possible belonging to 13 different signaling pathways in the cell. Read more below on how the Bladder Cancer Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators Includes more than 50 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 100 names
Developmental stage This Drug Pipeline Update contains 54 drugs in active development for treatment of bladder cancer:

5 marketed drugs
4 drugs in Phase III
17 drugs in Phase II
18 drugs in Phase I
7 drugs in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included bladder cancer drugs are in development for over 60 other indications
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to more than 38 different targets, divided into 20 classifications of molecular function:

Carboxy-lyase activity
Catalytic activity
Cell adhesion molecule activity
Chaperone activity
Chemokine activity
Cytokine activity
DNA repair protein
DNA topoisomerase activity
DNA-directed DNA polymerase activity
DNA-methyltransferase activity
Extracellular matrix structural constituent
G-protein coupled receptor activity
Growth factor activity
Hydrolase activity
Isomerase activity
Kinase activity
Lipase activity
MHC class I receptor activity
Molecular function unknown
Motor activity
Oxidoreductase activity
Protein binding
Protein serine/threonine kinase activity
Protein threonine/tyrosine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
RNA-directed DNA polymerase activity
Serine-type peptidase activity
Structural constituent of cytoskeleton
Superoxide dismutase activity
Transcription factor activity
Transcription regulator activity
Transferase activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Unclassified

Identified targets are categorized into 12 different primary and alternate localizations:

Clathrin-coated vesicle
Cytoplasm
Cytosol
Endoplasmic reticulum
Endosome
Extracellular
Lysosome
Mitochondrion
Nucleolus
Nucleus
Plasma membrane
Secretory granule

Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to protein expression profiles of 12 drug targets in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Signaling Pathways Identified targets have been cross referenced against 20 signaling pathways, and no less than 13 signaling pathways are currently being pursued in oncology drug development:

Alpha6 Beta4 Integrin Signaling Pathway
Androgen Receptor Signaling Pathway
EGFR1 Signaling Pathway
IL-1 Signaling Pathway
IL-2 Signaling Pathway
IL-3 Signaling Pathway
IL-4 Signaling Pathway
IL-5 Signaling Pathway
IL-6 Signaling Pathway
Notch Signaling Pathway
T Cell Receptor Signaling Pathway
TGF-beta Receptor Signaling Pathway
TNF-alpha Signaling Pathway

Note: You are able to sort and find drugs according to targeted signaling pathway from drop-down menu in the application.

Mechanism In total there are at least 48 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms (if any)

Principal Investigator & Partners
Presentation of principal investigator and partners (if any)

Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Signaling Pathways
Described target(s) is/are matched for the involvement in 20 major signaling pathways.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs