Cancer Vaccines

Cancer vaccines offer an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. However, despite years of R&D, a reproducible survival benefit has proved elusive, leaving the market wide open.

There are today more than 310 cancer vaccines, from early preclinical to marketed drugs. Cancer Vaccines Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 84 different targets. These targets are further categorized on the CD-ROM by 35 classifications of molecular function and their possible belonging to 17 different signaling pathways in the cell. Read more below on how the Cancer Vaccines Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators Includes more than 180 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 700 names
Developmental stage This Drug Pipeline Update contains more than 310 cancer vaccine drugs in active development and 480 developmental projects for the treatment of cancer.

• 25 projects in Phase III
• 135 projects in Phase II
• 95 projects in Phase I
• 190 projects in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included cancer vaccine drugs target 46 different cancer indications, or 80 indications in all.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to 84different targets, divided into 35classifications of molecular function:

• Carboxypeptidase activity
  
• Catalytic activity
  
• Cell adhesion molecule activity
  
• Cofactor binding
  
• Complement activity
  
• Cytokine activity
  
• DNA topoisomerase activity
  
• DNA-directed DNA polymerase activity
  
• Growth factor activity
  
• Heat shock protein activity
  
• Hormone activity
  
• Intracellular ligand-gated ion channel activity
  
• Isomerase activity
  
• Ligand-dependent nuclear receptor activity
  
• Metallopeptidase activity
  
• MHC class I receptor activity
  
• Molecular function unknown
  
• Oxidoreductase activity
  
• Peptidase activity
  
• Peptide hormone
  
• Protein binding
  
• Protein serine/threonine kinase activity
  
• Protein-tyrosine kinase activity
  
• Receptor activity
  
• Receptor binding
  
• Receptor signaling complex scaffold activity
  
• Receptor signaling protein serine/threonine kinase activity
  
• RNA-directed DNA polymerase activity
  
• Serine-type peptidase activity
  
• Transcription factor activity
  
• Transcription regulator activity
  
• Transmembrane receptor activity
  
• Transmembrane receptor protein tyrosine kinase activity
  
• Transporter activity
  
• Unclassified
  

dentified targets are categorized into 16 different primary and alternate localizations:

• Cell surface
  
• Centrosome
  
• Clathrin-coated vesicle
  
• Cytoplasm
  
• Endoplasmic reticulum
  
• Endosome
  
• Extracellular
  
• Extracellular matrix
  
• Golgi apparatus
  
• Mitochondrial matrix
  
• Mitochondrion
  
• Nucleolus
  
• Nucleus
  
• Peroxisomal matrix
  
• Plasma membrane
  
• Secretory granule

Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to protein expression profiles of 32 drug targets in various human tissues, cell lines and primary cells, including up to:

• 48 different normal tissue types
  
• 20 different types of cancer
  
• 47 cell lines
  
• 12 samples of primary blood cells
  

argeted Signaling Pathways Identified targets have been cross referenced against 20 signaling pathways, and no less than 17 are currently being pursued in cancer vaccine drug development:

• Alpha6 Beta4 Integrin Signaling Pathway
  
• Androgen Receptor Signaling Pathway
  
• B Cell Receptor Signaling Pathway
  
• EGFR1 Signaling Pathway
  
• Hedgehog Signaling Pathway
  
• IL-2 Signaling Pathway
  
• IL-3 Signaling Pathway
  
• IL-4 Signaling Pathway
  
• IL-5 Signaling Pathway
  
• IL-6 Signaling Pathway
  
• IL-7 Signaling Pathway
  
• Kit Receptor Signaling Pathway
  
• Notch Signaling Pathway
  
• T Cell Receptor Signaling Pathway
  
• TGF-beta Receptor Signaling Pathway
  
• TNF-alpha Signaling Pathway
  
• Wnt Signaling Pathway
  

ote: You are able to sort and find drugs according to targeted signaling pathway from drop-down menu in the application.

Mechanism In total there are at least 57 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms (if any)

Principal Investigator & Partners
Presentation of principal investigator and partners (if any)

Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Signaling Pathways
Described target(s) is/are matched for the involvement in 20 major signaling pathways.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs

• Drug status
  
• Clinical Trial Status
  
• Principle Investigator
  
• Partners
  
• Indication
  
• Developmental Stage
  
• Compound Type
  
• Mechanism
  
• Target
  
• Molecular Function of Target
  
• Target Localization
  
• Targeted Signaling Pathways
  
• Free text search of entire drug profile contents
  

irect linkage from inside the application to related internet resources

• Drug data is linked to search engines like Google and PubMed
  
• Target data is linked directly to Human Protein Atlas
  
• Direct links to company web pages of principal investigators

Export and sharing of information

• Found information is easily shared with others over e-mail, file export (xls) or in print

System Requirements - AMD-Athlon/Pentium II PC

• Windows 98/NT4/2000/ME/XP
  
• 8x-speed CD Rom drive
  
• SVGA 16 bit display. (32 bit recommended)
  
• 32 MB of available RAM (128 MB recommended)
  
• Internet access (for related internet resources)