Immunotherapy in Oncology: Drug Pipeline Update 2009

Publication Date	January 2009
Publisher	Bioseeker
Product Type	CD-ROM
Pages
ISBN Number	not applicable
Product Code	BSK00049

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Summary

Cancer immunotherapy offers an attractive therapeutic addition, delivering treatment of high specificity, low toxicity and prolonged activity. In this Drug Pipeline Update BioSeeker brings together the fields of antibodies, vaccines, and immunostimulators in oncology drug development into one source.

There are today more than 396 immunotherapy drugs in active development for the treatment of cancer, from early preclinical to marketed drugs. In addition, the accumulated number of ceased drugs over the last three years amount to another 178 drugs. Immunotherapy in Oncology: Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 158 different targets. These targets are further categorized on the CD-ROM by 45 classifications of molecular function and with pathway referals to BioCarta, KEGG and NetPath. Read more below on how the Immunotherapy in Oncology: Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators Includes more than 291 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 650 names
Developmental stage This Drug Pipeline Update contains 396 immunotherapy drugs in active development and 674 developmental projects:

40 projects have reached market approval
2 projects have been registered
6 projects in pre-registration
26 projects in Phase III
202 projects in Phase II
145 projects in Phase I
249 projects in Preclinical
4 projects in other developmental stages

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included immunotherapy drugs are in development for 148 indications, where of 68 are different cancer indications. All drugs are in development for the treatment of cancer.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to more than 158 different targets, divided into 45 classifications of molecular function:

Acid phosphatase activity
Carboxypeptidase activity
Catalytic activity
Cell adhesion molecule activity
Chemokine activity
Cofactor binding
Complement activity
Cytokine activity
DNA binding
DNA topoisomerase activity
DNA-directed DNA polymerase activity
Extracellular ligand-gated ion channel activity
Extracellular matrix structural constituent
G-protein coupled receptor activity
Growth factor activity
Heat shock protein activity
Hormone activity
Intracellular ligand-gated ion channel activity
Isomerase activity
Kinase activity
Kinase binding
Ligand-dependent nuclear receptor activity
Lipid phosphatase activity
Metallopeptidase activity
MHC class I receptor activity
Molecular function unknown
Oxidoreductase activity
Peptidase activity
Peptide hormone
Protein binding
Protein serine/threonine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
Receptor signaling protein serine/threonine kinase activity
RNA-directed DNA polymerase activity
Serine-type peptidase activity
T cell receptor activity
Transcription factor activity
Transcription regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity
Unclassified

Identified targets are categorized into 23 different primary and alternate sub-cellular localizations:

Apical membrane
Cell surface
Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoskeleton
Endoplasmic reticulum
Endosome
Extracellular
Extracellular matrix
Golgi apparatus
Integral to membrane
Lysosome
Mitochondrial matrix
Mitochondrion
Nuclear membrane
Nucleolus
Nucleus
Peroxisomal matrix
Plasma membrane
Secreted
Secretory granule
Vesicle

Note: You are able to sort and find drugs according to target gene name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to 142 protein expression profiles of 96 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Pathway Referals Identified targets have been cross referenced against their invovlement in different cellular pathways, according to BioCarta, KEGG and NetPath.

BioCarta 169 Pathways
KEGG 77 Pathways
NetPath 19 Signaling Pathways

Note: You are able to sort and find drugs according to targeted pathways from drop-down menues in the application.

Mechanism In total there are 148 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms

Principal Investigator & Partners
Presentation of principal investigator and partners

Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, and NetPath.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs

Drug status
Clinical Trial Status
Principle Investigator
Partners
Indication
Developmental Stage
Compound Type
Mechanism
Target
Molecular Function of Target
Target Localization
Targeted Pathways
Free text search of entire drug profile contents

Direct linkage from inside the application to related internet resources

Drug data is linked to search engines like Google and PubMed
Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, and NetPath
Direct links to company web pages of principal investigators

Export and sharing of information