Ovarian Cancer Drug Pipeline Update 2007

Publication Date	May 2007
Publisher	Bioseeker
Product Type	CD-ROM
Pages
ISBN Number	not applicable
Product Code	BSK00018

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Summary

Executive Summary

With nearly 60,000 cases of ovarian cancer being diagnosed in the seven major markets each year, this cancer type is by no means small and therefore it remains an important secondary indication for existing and pipeline drugs.

There are today more than 175 therapeutics targeting ovarian cancer, from early preclinical to marketed drugs. Ovarian Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 111 different targets. These targets are further categorized on the CD-ROM by 41 classifications of molecular function and their possible belonging to 20 different signaling pathways in the cell. Read more below on how the Ovarian Cancer Drug Pipeline Update is organized.

How May Drug Pipeline Update Be of Use?

Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
Find competitors, collaborations partners, M&A candidates etc.
Jump start competitive drug intelligence operations
Excellent starting point for world wide benchmarking
Compare portfolio and therapy focus with your peers
Speed up pro-active in-/out licensing strategy work
Fast and easy way of tracking drugs using search engines; just one click and you may search the World Wide Web and PubMed for any drug.
Drug Pipeline Update is delivered to you as a CD-ROM application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators Includes more than 140 principal investigators plus their collaborators. There is direct access from inside the application to web pages of all principal investigators.
Note: You are able to sort and find drugs according to investigators and partners from drop-down menus in the application. You may also sort and find drugs according to country of investigator.

Drug name & Synonyms Lists commercial, generic and code names for drugs. In all more than 300 names
Developmental stage This Drug Pipeline Update contains more than 175 drugs in active development for the treatment of ovarian cancer:

19 marketed drugs 9 drugs in Phase III

65 drugs in Phase II
40 drugs in Phase I
35 drugs in Preclinical

Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications Included ovarian cancer drugs are also in development for over 90 other indications.
Note: You are able to sort and find drugs according to type of indication from drop-down menu in the application.

Targets Identified drugs are linked to 111different targets, divided into 41classifications of molecular function:

Carboxy-lyase activity
Catalytic activity
Cell adhesion molecule activity
Chaperone activity
Cysteine-type peptidase activity
Cytokine activity
Deaminase activity
DNA binding
DNA repair protein
DNA topoisomerase activity
DNA-directed DNA polymerase activity
DNA-methyltransferase activity
G-protein coupled receptor activity
Growth factor activity
Hormone activity
Hydrolase activity
Kinase activity
Ligand-dependent nuclear receptor activity
Ligase activity
Lipid phosphatase activity
MHC class I receptor activity
Molecular function unknown
Motor activity
Oxidoreductase activity
Phosphoric diester hydrolase activity
Phosphorylase activity
Protein binding
Protein serine/threonine kinase activity
Protein-tyrosine kinase activity
Receptor activity
Receptor binding
Receptor signaling complex scaffold activity
RNA binding
Serine-type peptidase activity
Structural constituent of cytoskeleton
Superoxide dismutase activity
T cell receptor activity
Transcription factor activity
Transcription regulator activity
Transferase activity
Translation regulator activity
Transmembrane receptor activity
Transmembrane receptor protein tyrosine kinase activity
Transporter activity
Unclassified

Identified targets are categorized into 19 different primary and alternate localizations:

Cell surface
Centrosome
Clathrin-coated vesicle
Cytoplasm
Cytoplasmic vesicle
Cytoskeleton
Cytosol
Endoplasmic reticulum
Endosome
Extracellular
Golgi apparatus
Integral to membrane
Lysosome
Mitochondrial membrane
Mitochondrion
Nucleolus
Nucleus
Perinuclear region
Perinuclear vesicle
Peroxisome
Plasma membrane
Secretory granule

Note: You are able to sort and find drugs according to target name, molecular function of target, and target localization from drop-down menus in the application.

Target Expression Profile Direct links are provided from inside the application to protein expression profiles of 55 drug targets in various human tissues, cell lines and primary cells, including up to:

48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Signaling Pathways Identified targets have been cross referenced against 20 signaling pathways, and all of them are currently being pursued in ovarian cancer drug development:

Alpha6 Beta4 Integrin Signaling Pathway
Androgen Receptor Signaling Pathway
B Cell Receptor Signaling Pathway
EGFR1 Signaling Pathway
Hedgehog Signaling Pathway
ID Signaling Pathway
IL-1 Signaling Pathway
IL-2 Signaling Pathway
IL-3 Signaling Pathway
IL-4 Signaling Pathway
IL-5 Signaling Pathway
IL-6 Signaling Pathway
IL-7 Signaling Pathway
IL-9 Signaling Pathway
Kit Receptor Signaling Pathway
Notch Signaling Pathway
T Cell Receptor Signaling Pathway
TGF-beta Receptor Signaling Pathway
TNF-alpha Signaling Pathway
Wnt Signaling Pathway

Note: You are able to sort and find drugs according to targeted signaling pathway from drop-down menu in the application.

Mechanism In total there are at least 112 different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to sort and find drugs according to mechanism of action from drop-down menu in the application.

Compound Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms (if any)

Principal Investigator & Partners
Presentation of principal investigator and partners (if any)

Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol - Official Gene Name [Species/Homo Sapiens] - Molecular Function

Target Localization
Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Targeted Signaling Pathways
Described target(s) is/are matched for the involvement in 20 major signaling pathways.

Mechanism
Drug mechanism of action

Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma - Phase II Clinical Trial - Active
Cancer, prostate - Phase III Clinical Trial - Ceased

Drug Description
Short introduction to drug

Compound Data
Compound type, Chemical name, CAS Number and molecular weight

Patent Data
Available patent information related to the drug is presented here.

Business & Markets
Collaborations and deals
Approvals and submissions
Analyst comments

Phase III Data
Available Phase III development data, developmental history and scientific data.

Phase II Data
Available Phase II development data, developmental history and scientific data.

Phase I Data
Available Phase I development data, developmental history and scientific data.

Preclinical Data
Available preclinical development data, developmental history and scientific data.

Licensing Information
Availability for licensing

Application Features Use 13 different parameters, available in drop-down menus, to find and sort among drugs