Excipients

US industry forecasts for 2011 & 2016

Publication Date	January 2008
Publisher	Freedonia Group
Product Type	Report
Pages	291
ISBN Number	not applicable
Product Code	FED00153

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Summary

US demand to grow 4.4% annually through 2011

US demand for pharmaceutical excipients will expand 4.4 percent annually to $3.1 billion in 2011. Growth opportunities will extend to a wide range of compounds and applications. Based on advances in material quality and processing safety, gelatin will remain the dominant compound for drug encapsulation, warding off challenges from more expensive cellulosic and vegetable oil derivatives. Due to the breadth of existing and potential applications in drug formulations and delivery systems, cellulose derivatives will eventually evolve into the top-selling group of pharmaceutical excipients. These compounds will command especially strong growth opportunities as controlled release agents and in specialty uses such as enteric coatings and chewable tablets.

Minerals to be fastest growing excipent product

Ongoing efforts to improve the bioavailability and safety of parenteral and inhalation drugs will boost demand for specialty polymer excipients, especially compounds with sustained-release and targeting properties. In addition, multifunctional synthetic polymers, such as povidone, will broaden applications in high value-added oral medicines, including disintegrating tablets and controlled-release drug delivery systems.

Through 2011, minerals will command the strongest growth in demand value among all pharmaceutical excipients based on a favorable mix of cost and performance properties. Calcium phosphate and calcium carbonate as tablet fillers, titanium dioxide as a tablet coatings, and petrolatum and mineral oils in topical drug suspensions will fare particularly well in the marketplace. Cost and quality advantages will also expand market opportunities for starchbased pharmaceutical excipients, with pregelatinized starch fillers and binders and sodium starch glycolate disintegrants commanding the best sales growth. Based on ease of processing advantages and good compacting and compression properties, lactose will retain widespread usage as a tablet filler and diluent.

Sorbitol and mannitol will see the strongest demand growth among polyol excipients, the former from uses as a liquid drug diluent, the latter from applications as a diluent in parenteral preparations. Among other pharmaceutical excipients, sterile water and FD&C colors will continue to post the largest sales.

Demand for sterile water will increase with upward trends in the development and production of parenteral drugs, especially recombinant DNA and monoclonal antibody preparations. Efforts to reduce drug dispensing errors and strengthen drug anti-counterfeiting safeguards will prompt pharmaceutical producers to expand the use of FD&C colors as well as specialty ink excipients.

Study coverage

Excipients, a new Freedonia industry study, is available for $4500. It presents historical demand data for 1996, 2001 and 2006 plus forecasts for 2011 and 2016 by excipient product and application.

The study also considers market environment factors, evaluates company market share data and profiles 50 US industry competitors.

Content

SECTION
- INTRODUCTION
I. EXECUTIVE SUMMARY
II. MARKET ENVIRONMENT
- General
- Economic Factors
- Demographic Patterns
- Health Care Trends
- Health Insurance
- Medical Conditions
- Acute Conditions
- Chronic Conditions
- National Health Expenditures
- Medical Providers
- Hospitals
- Outpatient Facilities
- Other Health Care Establishments
- Physicians
- Dentists
- Patient Activity
- Hospital Activity
- Surgical Procedures
- Outpatient Episodes
- Pharmaceutical Industry Trends
- Regulation
- Research & Development
- Product Shipments
- Therapeutic Classes
- Dosage Formulations
- Regulatory Status
- Pharmaceutical Excipient Market Overview
- Historical Demand Patterns
- US Trade
- International Markets
III. PRODUCTS
- General
- Product Groups
- Gelatin
- Gelatin Types & Properties
- Pharmaceutical Excipient Applications
- Hard Gelatin Capsules
- Soft Gelatin Capsules
- Gelatin Binders
- Other Gelatin Excipients
- Suppliers
- Cellulose Derivatives
- Microcrystalline Cellulose (MCC)
- Hydroxypropyl Methylcellulose (HPMC)
- Ethyl Cellulose
- Methyl Cellulose
- Carboxymethylcellulose (CMC)
- Croscarmellose Sodium
- Other Cellulose Excipients
- Cellulose Acetate
- Hydroxyethyl Cellulose (HEC)
- Hydroxypropyl Cellulose (HPC)
- Hydroxypropyl Methylcellulose Acetate
- Succinate (HPMCAS)
- Low-Substituted Hydroxypropyl Cellulose (LSHPC)
- Powdered Cellulose
- Synthetic Polymers
- Povidone
- Acrylic Polymers
- Carbomers
- Methacrylates
- Polyethylene Glycol
- Other Synthetic Polymers
- Polyethylene Oxide
- Polyvinyl Acetate Phthalate
- Polyvinyl Alcohol
- Propylene Glycol
- Minerals
- Calcium Phosphate
- Mineral Hydrocarbons
- Petrolatum
- Mineral Oil
- Mineral Hydrocarbon Waxes
- Calcium Carbonate
- Titanium Dioxide
- Silicon Dioxide
- Other Mineral Fillers/Diluents
- Calcium Sulfate
- Kaolin
- Other Mineral Excipients
- Attapulgite
- Bentonite
- Calcium Silicate
- Ceresin Wax
- Talc
- Starch Compounds
- Pregelatinized Starch
- Sodium Starch Glycolate
- Other Starch Excipients
- Native Starches
- Cyclodextrins
- Maltodextrin
- All Other Starch Compounds
- Sugars
- Lactose
- Sucrose
- Other Sugar Excipients
- Compressible Sugar
- Confectioner's Sugar
- Fructose
- Galactose & Liquid Glucose
- Glycerin
- Maltose
- Tagatose
- Xanthan Gum
- Polyols
- Sorbitol
- Mannitol
- Other Polyol Excipients
- Isomalt
- Lactitol
- Maltitol
- Xylitol
- Other Pharmaceutical Excipients
- Sterile & Purified Waters
- Types of Sterile & Purified Pharmaceutical Waters
- Applications
- Surfactants
- Anionic Surfactants
- Cationic Surfactants
- Nonionic Surfactants
- Dyes & Pigments
- Acidulants
- Stearate Salts
- Calcium Stearate
- Magnesium Stearate
- Sodium Stearyl Fumarate
- Stearic Acid
- Zinc Stearate
- Antioxidants
- Natural Gums
- Agar
- Alginic Acid
- Carrageenan
- Gellan Gum
- Guar Gum
- Gum Acacia
- Tragacanth
- Electrolytes & Related Compounds
- Chemical Plasticizers
- All Other Compounds
- Artificial Sweeteners
- Cocoa Butter
- Glyceryl Behenate
- Hydrogenated Vegetable Oil
- Lanolin
- Natural Waxes
- Pectin
- Simethicone
- Other Pharmaceutical Excipient Demand by Application
IV. APPLICATIONS
- General
- Fillers/Diluents
- Capsules
- Binders
- Drug Delivery Agents
- Suspension/Viscosity Agents
- Coatings
- Flavoring Agents
- Disintegrants
- Colorants
- Preservatives
- Lubricants
- Glidants
V. INDUSTRY STRUCTURE
- General
- Market Share
- Competitive Strategies
- Mergers & Acquisitions
- Licensing & Related Agreements
- Marketing & Distribution
- Research & Development
- Manufacturing
- Company Profiles
- Akzo Nobel NV
- Aqualon, see Hercules
- Archer-Daniels-Midland Company
- Associated British Foods plc
- BASF AG
- Berwind Group
- Cabot Corporation
- Cargill Incorporated
- Celanese Corporation
- Chr. Hansen A/S
- Cognis Deutschland GmbH & Company KG
- Colorcon, see Berwind Group
- Covidien Limited
- Croda International plc
- CyDex Incorporated
- Danisco A/S
- Degussa AG, see RAG
- Delta Biotechnology Limited, see Novozymes
- Dow Chemical Company
- Eastman Chemical Company
- EMD Chemicals Incorporated, see Merck
- Ferro Corporation
- FibroGen Incorporated
- Flavorx Incorporated
- FMC Corporation
- GELITA AG
- Generichem Corporation
- Hercules Incorporated
- Huber (JM) Corporation
- Huntsman Corporation
- Imperial Chemical Industries plc
- Innophos Incorporated
- International Specialty Products Incorporated
- Kelco (CP), see Huber (JM)
- Lubrizol Corporation
- Lyondell Chemical Company
- Mallinckrodt Baker Incorporated, see Covidien
- Merck KGaA
- Mutchler Incorporated
- National Starch and Chemical Company, see
- Imperial Chemical Industries
- Nitta Gelatin Incorporated
- Noveon Incorporated, see Lubrizol
- Noviant Incorporated, see Huber (JM)
- NutraSweet Company
- Nutrinova Incorporated, see Celanese
- Procter & Gamble Company
- RAG AG
- Rohm and Haas Company
- Rhm Pharma Polymers, see RAG
- Roquette Freres SA
- Royal Dutch Shell plc
- Sasol Limited
- Solvay SA
- SPI Pharma Incorporated, see Associated British Foods
- Stepan Company
- Tate & Lyle plc
- Tyco Healthcare Limited, see Covidien
- Uniqema North America Incorporated, see Croda
- USG Corporation
- Wacker-Chemie AG
LIST OF TABLES
- TABLE NUMBER
SECTION I -- EXECUTIVE SUMMARY
- Summary Table
SECTION II -- MARKET ENVIRONMENT
- 1 Macroeconomic Indicators
- 2 Population by Age Group
- 3 Acute Conditions by Type
- 4 Selected Chronic Conditions by Type
- 5 National Health Expenditures by Type
- 6 Medical Providers by Type
- 7 Patient Activity by Type
- 8 Pharmaceutical Shipments by Therapeutic Class
- 9 Pharmaceutical Shipments by Dosage Formulation
- 10 Pharmaceutical Shipments by Regulatory Classification
- 11 Excipient Demand Patterns, 1996-2006
- 12 US Trade in Excipients
- 13 World Excipient Demand by Market
SECTION III -- PRODUCTS
- 1 Pharmaceutical Excipient Demand by Product Group
- 2 Gelatin Excipient Demand by Application
- 3 Cellulose Excipient Demand by Type
- 4 Microcrystalline Cellulose Excipient Demand by Application
- 5 Hydroxypropyl Methylcellulose (HPMC) Excipient Demand by Application
- 6 Ethyl Cellulose Excipient Demand by Application
- 7 Methyl Cellulose Excipient Demand by Application
- 8 Carboxymethylcellulose Excipient Demand by Application
- 9 Croscarmellose Sodium Excipient Demand by Application
- 10 Other Cellulose Excipient Demand by Application
- 11 Synthetic Polymer Excipient Demand by Type
- 12 Povidone Excipient Demand by Application
- 13 Acrylic Polymer Excipient Demand by Application
- 14 Polyethylene Glycol (PEG) Excipient Demand by Application
- 15 Other Synthetic Polymer Demand by Application
- 16 Mineral Excipient Demand by Type
- 17 Calcium Phosphate Diluent/Filler Demand
- 18 Mineral Hydrocarbon Excipient Demand by Application
- 19 Calcium Carbonate Filler/Diluent Demand
- 20 Titanium Dioxide Coating Demand
- 21 Silicon Dioxide Excipient Demand by Application
- 22 Other Mineral Filler/Diluent Demand
- 23 Other Mineral Excipient Demand by Application
- 24 Starch Excipient Demand by Type
- 25 Pregelatinized Starch Excipient Demand by Application
- 26 Sodium Starch Glycolate Excipient Demand by Application
- 27 Other Starch Excipient Demand by Application
- 28 Sugar Excipient Demand by Type
- 29 Lactose Filler/Diluent Demand
- 30 Sucrose Excipient Demand by Application
- 31 Other Sugar Excipient Demand by Application
- 32 Polyol Excipient Demand by Type
- 33 Sorbitol Excipient Demand by Application
- 34 Mannitol Excipient Demand by Application
- 35 Other Polyol Excipient Demand by Application
- 36 Other Pharmaceutical Excipient Demand by Type
- 37 Other Pharmaceutical Excipient Demand by Application
SECTION IV -- APPLICATIONS
- 1 Pharmaceutical Excipient Demand by Application
- 2 Filler/Diluent Excipient Demand by Type
- 3 Capsule Excipient Demand by Type
- 4 Binder Excipient Demand by Type
- 5 Drug Delivery Excipient Demand by Type
- 6 Suspension/Viscosity Excipient Demand by Type
- 7 Coating Excipient Demand by Type
- 8 Flavoring Agent Excipient Demand by Type
- 9 Disintegrant Excipient Demand by Type
- 10 Colorant Excipient Demand by Type
- 11 Preservative Excipient Demand by Type
- 12 Lubricant Excipient Demand by Type
- 13 Glidant Excipient Demand by Type
SECTION V -- INDUSTRY STRUCTURE
- 1 Excipient Sales by Company, 2006
- 2 Selected Acquisitions & Divestitures
- 3 Selected Cooperative Agreements
LIST OF CHARTS
- CHART NUMBER
SECTION III -- PRODUCTS
- 1 Excipient Demand by Product Group, 2006
- 2 Cellulose Excipient Demand by Compound, 2006
- 3 Synthetic Polymer Excipient Demand by Compound, 2006
SECTION IV -- APPLICATIONS
- 1 Excipient Demand by Application, 2006
SECTION V -- INDUSTRY STRUCTURE
- 1 Excipients - US Market Share by Company, 2006