Excipients in Pharmaceuticals

Publication Date	June 2007
Publisher	BCC Research
Product Type	Report
Pages	160
ISBN Number	not applicable
Product Code	BCC00139

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Summary

Introduction

The global market for pharmaceutical ingredients continues to evolve and expand as research seeks to develop and improve relevant processes and technologies. BCC Research was among the first market research companies to undertake an in-depth look at excipients in drug formulations and to publish a multi-client business analysis on the subject. New demands on performance and quality have changed the shape of the pharmaceutical industry, exposing deficiencies in the old assumptions about the worth of excipients in a pharmaceutical formulation. More widespread and precise testing has proven that inert ingredients in drug formulations contribute more than bulk and can even affect the performance of the active (therapeutic) ingredient. As a result, market dynamics with respect to formulated drugs has changed and the supply of the ingredients has broadened internationally. This updated BCC Research technical/marketing study, Excipients in Pharmaceuticals, explores the impact that advancements in the field are expected to have over the next 5 years.

Scope Of Study

This report contains:

General information on inert ingredients, the types of technologies used to make them, their uses, and regulatory influences
Excipients by chemical compounds, functional uses, delivery systems, and finished products
Market environment, strategies, influences, and shares, international aspects, and other related factors
Five year market forecasts through 2011 of compounds, delivery systems and finished products
Company profiles that summarizes the leading industry participants.

Report Highlights

The chemical compounds used to make excipients are valued at $4.3 billion market value for 2011, up from $3.5 billion in 2006. The dominance of USP water, particularly water for injection, skews the market volume and sets the pace for the anticipated 5.1% average annual market volume growth rate over the next five years.
Formulators will continue to use excipients to give their final drug products the necessary or desired functional use or properties. Vehicles, with an estimated 2011 market volume of 9.6 billion pounds, lead due to the large amount of USP water consumed.
Fillers follow with an estimated 849 million pounds of excipient chemical compounds being used in that functional category in five years. In terms of market value, the situation is reversed. Fillers come out on top, with an estimated 2011 market value of $1.2 billion, and vehicles drop to third place with $781 million, just below emollients at $816 million.

Content

Introduction
- Reason For Doing The Study
- Goal And Objectives
- Audience
- Scope And Format
- Methodology And Sources
- Analyst Credentials
- Related Bcc Reports
- About Bcc Research
- Custom Analyses
- Bcc Online Services
- Disclaimer
Summary
- Summary Table: Global Excipient Chemicals Market Size By Type, Through 2011 (Millions)
- Summary Figure: Global Excipient Chemicals Market Size By Type, 2005-2011 ($ Millions)
Overview
- Global Chemical Compounds Market Size
  - Organic
  - Inorganic Chemicals
  - Usp Water
- Functional Uses
- Global Delivery Systems Market Size
- Global Finished Products Market Size
- Safety Issues
  - Purity
  - Unapproved Materials
  - Physiological Inertness
  - Material Interactions
  - Allergic Reactions
- Regulatory Issues
  - Fda
    - Approval Process
    - Excipient Approval
    - Drug Master File
    - Safety Guidance On New Excipients
    - Inactive Ingredient Guide
    - Labeling
    - Prescription Drugs
    - Otc Products
    - Current Good Manufacturing Practices
  - Usda
    - The Sugar Program
  - Compendia
    - Usp
  - Global Harmonization Standards
    - Ipec-Americas
  - Internal Company Scrutiny
Chemical Compounds
- Market Size
- Organic Chemicals
  - Market Size
  - Carbohydrates
    - Market Size
    - Celluloses
    - Market Size
    - Microcrystalline Cellulose
    - Market Size
    - Cellulose Ethers
    - Market Size
    - Cellulose Esters
    - Market Size
    - Carboxymethyl Cellulose
    - Market Size
    - Sugars
    - Market Size
    - Actual Sugars
    - Market Size
    - Lactose
    - Market Size
    - Sucrose
    - Market Size
    - Sugar Alcohols
    - Market Size
    - Sorbitol
    - Market Size
    - Mannitol
    - Market Size
    - Other Sugar Alcohols
    - Market Size
    - Erythritol
    - Isomalt
    - Maltitol
    - Tagatose
    - Trehalose
    - Xylitol
    - Artificial Sweeteners
    - Market Size
    - Acesulfame-Potassium
    - Aspartame
    - Neotame
    - Saccharin
    - Sucralose
    - Starches
    - Market Size
    - Dried Starch
    - Market Size
    - Modified Starch
    - Market Size
    - Converted Starch
    - Market Size
  - Petrochemicals
    - Market Size
    - Glycols
    - Market Size
    - Polyethylene Glycol
    - Market Size
    - Propylene Glycol
    - Market Size
    - Povidones
    - Market Size
    - Mineral Hydrocarbons
    - Market Size
    - Petrolatum
    - Market Size
    - Mineral Waxes
    - Market Size
    - Mineral Oils
    - Market Size
    - Acrylic Polymers
    - Market Size
    - Other Petrochemical Materials
    - Market Size
    - Antimicrobials
    - Antioxidants
    - Dyes And Lakes
    - Edta
    - Flavors
    - Glycine And Glycylglycine
    - Vinyl Polymers
    - Silicones
    - Miscellaneous Synthetic Petrochemicals
  - Oleochemicals
    - Market Size
    - Fatty Alcohols
    - Market Size
    - Glycerin
    - Market Size
    - Metal Stearates
    - Market Size
    - Other Oleochemicals
    - Market Size
    - Natural Waxes
    - Beeswax
    - Candelilla Wax
    - Carnauba Wax
    - Cocoa And Shea Butters
    - Lanolin
    - Phospholipids
    - Sodium Lauryl Sulfate
    - Sorbitan
    - Synthetic Glyceryl Esters
    - Vegetable Oils
  - Proteins
    - Gelatin
    - Market Size
    - Albumin
  - Other Organic Chemicals
    - Alcohols
    - Citric Acid
    - Lactic Acid
    - Polysaccharide Gums
    - Shellac
- Inorganic Chemicals
  - Market Size
  - Calcium Salts
    - Market Size
    - Calcium Phosphate
    - Market Size
    - Calcium Carbonate
    - Market Size
    - Calcium Sulfate
    - Market Size
  - Halites
    - Market Size
  - Metal Oxides
    - Market Size
    - Titanium Dioxide
    - Market Size
    - Iron Oxide
    - Market Size
  - Silicates
    - Market Size
    - Silicon Dioxide
    - Market Size
    - Talc
    - Market Size
    - Clay
    - Market Size
  - Other Inorganic Chemicals
    - Market Size
- Usp Water
  - Market Size
  - Water For Injection
    - Market Size
  - Purified Water
    - Market Size
Functional Uses
- Market Size
- Fillers
  - Market Size
- Emollients
  - Market Size
- Vehicles
  - Market Size
- Coatings
  - Market Size
- Disintegrants
  - Market Size
- Flavorants
  - Market Size
- Osmotic Agents
  - Market Size
- Colorants
  - Market Size
- Other Functional Uses
  - Market Size
  - Aroma Agents
  - Binders
  - Buffers
  - Chelating Agents
  - Foam Control Agents
  - Glidants
  - Humectants
  - Lubricants
  - Plasticizers
  - Preservatives
  - Thickeners
Delivery Systems
- Market Size
- Injection
  - Market Size
- Oral
  - Market Size
  - Solids
    - Market Size
    - Market Size
    - Capsules
    - Market Size
    - Hard Gelatin Capsules
    - Market Size
    - Soft Gelatin Capsules
    - Market Size
  - Liquids
    - Market Size
- Topical Delivery Systems
  - Market Size
  - Ointments
  - Creams And Gels
  - Lotions
  - Dermal Powders
  - Solutions
- Advanced Delivery Systems
  - Market Size
  - Cyclodextrins
  - Hydrogels
  - Implants
  - Liposomes
  - Microparticles
  - Microspheres
  - Nanoparticles
  - Osmotic Pumps
  - Protein-Coated Microcrystals
  - Transdermal
  - Transmucosal
    - Buccal
      - Tablets
      - Capsules
      - Lozenges
      - Particles
      - Thin Strips
      - Inhalation
      - Nasal
      - Pulmonary
      - Ophthalmic
      - Otic
      - Rectal
      - Vaginal
Finished Products
- Market Size
- Prescription Products
  - Market Size
  - Injection
    - Market Size
    - Chemically-Based Injections
    - Biologically-Based Injections
    - Protein Drugs
    - Vaccines
  - Oral
    - Market Size
  - Topical
  - Advanced Systems
- Over-The-Counter Products
  - Market Size
- Finished Product Trends
  - Pharmacogenomics
  - Counterfeit/Stolen Drugs
Industry Structure
- Industry Environment
  - Market Influences
    - Pharmaceutical Industry Pressures
    - General Health Trends
    - Healthcare Industry
    - Consumer Demographics
- Important Strategies
  - Research And Development Spending
  - Consumer Advertising
  - Legislative Lobbying
  - Consolidation
  - Multiplicity Of Delivery Systems
  - Supplier Lists
  - Material Choice Decisions
- Driving Forces
- Market Shares
  - Raw Material Suppliers
    - Organic Chemical Suppliers
    - Carbohydrate Suppliers
    - Cellulose Suppliers
    - Sugar Suppliers
    - Actual Sugar Suppliers
    - Sugar Alcohols
    - Artificial Sweeteners
    - Starch Suppliers
    - Protein Suppliers
    - Petrochemical Suppliers
    - Glycol Suppliers
    - Povidone Suppliers
    - Mineral Hydrocarbon Suppliers
    - Acrylic Suppliers
    - Oleochemical Suppliers
    - Inorganic Chemical Suppliers
    - Calcium Salts Suppliers
    - Halites Suppliers
    - Metal Oxide Suppliers
    - Silicate Suppliers
    - Usp Water Suppliers
  - Distributors/ Modifiers
    - Distributors
    - Brokers
    - Import/Export Traders
    - Chemical Stocking/Repackaging Distributors
    - Modifiers
    - Compounders
    - Contract Coaters
    - Semi-Formulators
  - End-Users
    - Drug Companies
    - Contract Formulators
    - Hospital And Retail Pharmacies
    - Pharmacy Colleges And Other Academic Institutions
    - Other End Users
- International Aspects
  - Americas
  - Europe
  - Asia/ Pacific Rim
  - Others
Company Profiles
- Aarhuskarlshamn Ab
- Akzo Nobel Nv
- Archer Daniels Midland
- Arla Foods Amba
- Associated British Foods, Plc
- Avebe Group
- Basf Ag
- Baxter Healthcare Corp.
- Bayer Ag
- Berwind Group
- Blanver Farmoquimica, Ltda.
- Wm. Bolthouse Farms, Inc.
- Cabot Corp.
- Campina
- Cargill, Inc.
- Celanese Corp.
- Chemische Fabrik Budenheim Kg
- Cognis Deutschland Gmbh & Co. Kg
- Corn Products International, Inc.
- Croda International, Plc
- Csm N.V.
- Danisco A/S
- Degussa Ag
- Dow Chemical Co.
- E. I. Du Pont De Nemours & Co.
- Eastman Chemical Co.
- Ferro Corp.
- Fibrogen, Inc.
- Flavorx, Inc.
- Fmc Corp.
- Fonterra Cooperative Group, Ltd.
- Foremost Farms USA
- Friesland Foods Domo
- Fuji Chemical Industry, Ltd.
- The Gattefossé Group
- Ge Healthcare Bio-Sciences
- Gelita Ag
- Grain Processing Corp.
- Grifols S.A.
- Gtc Therapeutics, Inc.
- Chr. Hansen A/S
- Hercules, Inc.
- Hilmar Cheese Co., Inc.
- Hollandse Melksuikerfabriek
- J. M. Huber Corp.
- Huntsman International, Llc
- Imerys
- Imperial Chemical Industries, Plc
- International Specialty Products
- Kemira Oy
- Koster Kuenen Holland Bv
- Kraft Foods-Woburn
- Kronos Worldwide, Inc.
- Lanxess Ag
- The Lubrizol Corp.
- Lyondell Chemical Co.
- Meggle Ag
- Merck Kgaa
- Ming Tai Chemical Co., Ltd.
- Minerals Technologies, Inc.
- Morflex, Inc.
- National Titanium Dioxide Co., Ltd.
- Nitta Gelatin, Inc.
- Nordzucker Ag
- Novozymes A/S
- The Nutrasweet Company
- Omya Ag
- Penreco, Inc.
- Pmc Global, Inc
- The Procter & Gamble Co.
- J. Rettenmaier & Sohne Gmbh & Co.
- Rhodia Pharmaceutical Products
- Rio Tinto Group
- Rohm & Haas Co.
- Roquette Freres
- Royal Dutch Shell, Plc
- Sasol, Ltd.
- Seppic Sa
- Shin-Etsu Chemical Co., Ltd.
- Sobel N.V.
- Solvay S.A.
- Stepan Co.
- Sterling Biotech, Ltd.
- Takehara Chemical Industrial, Ltd.
- Talecris Biotherapeutics, Inc.
- Tate & Lyle, Plc
- Tessenderlo Chemie N.V.
- Tomita Pharmaceutical Co., Ltd.
- Tyco International, Ltd.
- Usg Corp.
- R. T. Vanderbilt Company, Inc.
- Wacker Chemie Ag
- Zlb Behring, Llc
List Of Tables
- Summary Table: Global Excipient Chemicals Market Size By Type, Through 2011 (Millions)
- Table 1 Global Excipient Chemical Compounds Market Size By Type, Through 2011 (Millions)
- Table 2 Global Organic Chemicals Market Size, By Type, Through 2011 (Millions)
- Table 3 Global Carbohydrates Chemicals Market Size, By Type, Through 2011 (Millions)
- Table 4 Global Cellulose Excipients Market Size By Type, Through 2011 (Millions)
- Table 5 Global Mcc Excipients Market Size, Through 2011 (Millions)
- Table 6 Global Cellulose Ether Excipients Market Size, Through 2011 (Millions)
- Table 7 Global Cellulose Ester Excipients Market Size, Through 2011 (Millions)
- Table 8 Global Cmc Excipients Market Size, Through 2011 (Millions)
- Table 9 Global Sugar Excipients Market Size, By Type, Through 2011 (Millions)
- Table 10 Global Actual Sugar Excipients Chemicals Market Size, By Type, Through 2011 (Millions)
- Table 11 Global Lactose Excipient Market Size, Through 2011 (Millions)
- Table 12 Global Sucrose Excipients Market Size, Through 2011 (Millions)
- Table 13 Comparison Of Sugar Alcohols To Sucrose (%)
- Table 14 Global Sugar Alcohol Excipient Market Size, By Type, Through 2011 (Millions)
- Table 15 Global Sorbitol Excipients Market Size, Through 2011 (Millions)
- Table 16 Global Mannitol Excipients Market Size, Through 2011 (Millions)
- Table 17 Global Other Sugar Alcohol Excipients Market Size Through 2011 (Millions)
- Table 18 Global Artificial Sweetener Excipients Market Size, Through 2011 (Millions)
- Table 19 Global Starches Market Size, By Type, Through 2011 (Millions)
- Table 20 Global Dried Starch Excipients Market Size, Through 2011 (Millions)
- Table 21 Global Modified Starch Excipients Market Size, Through 2011 (Millions)
- Table 22 Global Converted Starch Excipients Market Size Through 2011 (Millions)
- Table 23 Global Petrochemicals Market Size, By Type, Through 2011 (Millions)
- Table 24 Global Glycol Excipients Market Size, By Type, Through 2011 (Millions)
- Table 25 Global Peg Excipients Market Size, By Type, Through 2011 (Millions)
- Table 26 Global Pg Excipients Market Size, By Type, Through 2011 (Millions)
- Table 27 Global Povidone Excipients Market Size, Through 2011 (Millions)
- Table 28 Global Mineral Hydrocarbon Excipients Market Size By Type, Through 2011 (Millions)
- Table 29 Global Petrolatum Excipients Market Size, Through 2011 (Millions)
- Table 30 Global Mineral Wax Excipients Market Size, Through 2011 (Millions)
- Table 31 Global Mineral Oil Excipients Market Size, Through 2011 (Millions)
- Table 32 Global Acrylic Excipients Market Size, Through 2011 (Millions)
- Table 33 Global Other Petrochemical Excipients Market Size, Through 2011 (Millions)
- Table 34 Synthetic Colorants Used In Pharmaceuticals
- Table 35 Global Oleochemicals Market Size, By Type, Through 2011 (Millions)
- Table 36 Global Fatty Alcohol Excipients Market Size, Through 2011 (Millions)
- Table 37 Global Glycerin Excipients Market Size, Through 2011 (Millions)
- Table 38 Global Metal Stearate Excipients Market Size, Through 2011 (Millions)
- Table 39 Global Other Oleochemical Excipients Market Size Through 2011 (Millions)
- Table 40 Global Proteins Market Size, By Type, Through 2011 (Millions)
- Table 41 Global Other Organic Chemical Excipients Market Size, Through 2011 (Millions)
- Table 42 Global Inorganic Chemical Excipients Market Size, By Type, Through 2011 (Millions)
- Table 43 Global Calcium Salt Excipients Market Size, Through 2011 (Millions)
- Table 44 Global Calcium Phosphate Excipients Market Size, Through 2011 (Millions)
- Table 45 Global Calcium Carbonate Excipients Market Size, Through 2011 (Millions)
- Table 46 Global Calcium Sulfate Excipients Market Size Through 2011 (Millions)
- Table 47 Global Halite Excipients Market Size, Through 2011 (Millions)
- Table 48 Global Metal Oxide Excipients Market Size By Type, Through 2011 (Millions)
- Table 49 Global Titanium Dioxide Excipients Market Size, Through 2011 (Millions)
- Table 50 Global Iron Oxide Excipients Market Size, Through 2011 (Millions)
- Table 51 Global Silicate Excipients, By Type, Through 2011 (Millions)
- Table 52 Global Silicon Dioxide Excipients Market Size, Through 2011 (Millions)
- Table 53 Global Talc Excipients Market Size, Through 2011 (Millions)
- Table 54 Global Clay Excipients Market Size, Through 2011 (Millions)
- Table 55 Global Other Inorganic Chemical Excipients Market Size, Through 2011 (Millions)
- Table 56 Global Usp Water Excipients Market Size, By Type Through 2011 (Millions)
- Table 57 Global Usp Wfi Excipients Market Size, Through 2011 (Millions)
- Table 58 Global Usp Purified Water Excipient Market Size Through 2011 (Millions)
- Table 59 Ipec Functional Uses For Excipients
- Table 60 Global Excipient Functional Uses Market Size By Type, Through 2011 (Millions)
- Table 61 Global Excipient Fillers Market Size By Chemical Type, Through 2011 (Millions)
- Table 62 Global Excipient Emollients Market Size By Chemical Type, Through 2011 (Millions)
- Table 63 Global Excipient Vehicles Market Size By Chemical Type, Through 2011 (Millions)
- Table 64 Global Excipient Coatings Market Size By Chemical Type, Through 2011 (Millions)
- Table 65 Global Disintegrants Market Size By Chemical Type, Through 2011 (Millions)
- Table 66 Global Flavorants Market Size By Chemical Type, Through 2011 (Millions)
- Table 67 Comparison Of Select Sweeteners To Sucrose (%)
- Table 68 Global Osmotic Agents Market Size By Chemical Type, Through 2011 (Millions)
- Table 69 Global Colorants Market Size, By Chemical Type Through 2011 (Millions)
- Table 70 Global Other Functional Uses Market Size Through 2011 (Millions)
- Table 71 Global Excipient Delivery Systems Market Size, By Type, Through 2011 (Millions)
- Table 72 Typical Injection Composition (%)
- Table 73 Global Excipients For Injections Market Size By Function, Through 2011 (Millions)
- Table 74 Global Excipients In Oral Delivery Systems Market Size, By Type, Through 2011 (Millions)
- Table 75 Global Excipients In Oral Solids Delivery Systems Market Size, By Type, Through 2011 (Millions)
- Table 76 Typical Composition Of An Ordinary Tablet
- Table 77 Global Excipients In Tablets Market Size, By Function, Through 2011 (Millions)
- Table 78 Global Excipients In Gelatin Capsules Market Size By Type, Through 2011 (Millions)
- Table 79 Typical Hard Gelatin Capsule Composition
- Table 80 Global Excipients In Hard Gelatin Capsules Market Size By Function, Through 2011 (Millions)
- Table 81 Typical Composition Of A Soft Gelatin
- Table 82 Global Excipients In Soft Gelatin Capsules Market Size By Function, Through 2011 (Millions)
- Table 83 Typical Liquid Composition (%)
- Table 84 Global Excipients In Liquids Market Size, By Function, Through 2011 (Millions)
- Table 85 Global Excipients In Topical Delivery Systems, By Type, Through 2011 (Millions)
- Table 86 Typical Ointment Composition (%)
- Table 87 Typical Cream Composition (%)
- Table 88 Typical Topical Lotion Composition (%)
- Table 89 Global Advanced Delivery Systems, By Functional Use, Through 2011 (Millions)
- Table 90 Global Excipients In Finished Products By Type, Through 2006 (Millions)
- Table 91 Global Excipients In Rx Drugs, By Delivery System Type, Through 2011 (Millions)
- Table 92 Global Excipients In Injected Rx Drugs, By Type, Through 2011 (Millions)
- Table 93 Global Excipients In Injected Rx Chemical Drugs Market Size, Through 2011 (Millions)
- Table 94 Global Excipients In Injected Rx Biologic Drugs Market Size, Through 2011 (Millions)
- Table 95 Global Excipients In Oral Rx Drugs Market Size, Through 2011 (Millions)
- Table 96 Global Excipients In Topical Rx Drugs Market Size, Through 2011 (Millions)
- Table 97 Global Excipients In Advanced Systems For Rx Drugs Market Size, Through 2011 (Millions)
- Table 98 Global Excipients In Otc Finished Products, By Delivery System Type, Through 2011 (Millions)
- Table 99 Projected Global Population Growth, 2000-2050 (Millions Of Persons)
- Table 100 Selected Organic Chemicals For Excipients Suppliers
- Table 101 Selected Polyol Manufacturers
- Table 102 Selected Inorganic Chemical Suppliers For Excipients
- Table 103 Categories Of Distributors
- Table 104 Categories Of Modifiers
- Table 105 Categories Of End Users
- Table 106 Top 10 Global Big Pharma Companies, 2005 ($ Billions)
List Of Figures
- Summary Figure: Global Excipient Chemicals Market Size By Type, 2005-2011 ($ Millions)
- Figure 1 Global Chemical Compound Excipients Market Share, 2006 (%)
- Figure 2 Global Organic Chemical Excipients Market Share By Type, 2006 (%)
- Figure 3 Global Inorganic Chemical Excipients Market Share, By Type, 2006 (%)
- Figure 4 Global Usp Water Exicipients Market Share, 2006 (%)
- Figure 5 Global Excipients Functional Uses Market Share, By Type, 2006 (%)
- Figure 6 Global Excipients In Delivery Systems, Market Share, By Type, 2006 (%)
- Figure 7 Global Excipients In Finished Products Market Share, By Type, 2006 (%)
- Figure 8 Global Excipient Chemical Compounds Market Size By Type, 2005-2011 ($ Millions)
- Figure 9 Global Excipient Functional Uses Market Size, By Type, 2006-2011 ($ Millions)
- Figure 10 Global Excipient Delivery System Market Size, By Type, 2005-2011 ($ Millions)
- Figure 11 Simplified Industry
- Figure 12 Market Share Of Major Cellulose Suppliers, 2006 (%)
- Figure 13 Market Share Of Major Sugars Excipients Suppliers, 2006 (%)
- Figure 14 Market Share Of Major Sugar Alcohol Excipient Suppliers, 2006 (%)
- Figure 15 Market Share Of Major Starch Excipient Suppliers, 2006 (%)
- Figure 16 Market Share Of Major Protein Excipient Suppliers, 2006 (%)
- Figure 17 Market Share Of Major Glycol Excipient Suppliers, 2006 (%)
- Figure 18 Market Share Of Major Oleochemical Excipient Suppliers, 2006 (%)
- Figure 19 Market Share Of Major Calcium-Based Excipient Suppliers, 2006 (%)
- Figure 20 Market Share Of Major Halite Excipient Suppliers, 2006 (%)
- Figure 21 Market Share Of Major Metal Oxide Excipient Suppliers, 2006 (%)
- Figure 22 Market Share Of Major Usp Water Suppliers, 2006 (%)
- Figure 23 Regional Market Share Of Excipients, 2006 (%)