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Global Transfection Markets

  • Publication Date:November 2010
  • Publisher:Frost & Sullivan
  • Product Type: Report
  • Pages:66

Global Transfection Markets

This research service provides an analysis of the Global Transfection Market with market size and growth estimates through the forecast period of 2006 through 2016. The global transfection market is segmented into four technology markets: the Commercial Transfection Reagents Market, the Electroporation Market, the Homebrew Transfection Reagents Market, and the Viral Delivery Tools Market. In addition, the market is segmented into three application markets: the Transfection Market for Gene and Protein Expression, the Transfection Market for RNA Interference (RNAi), and the Transfection Market for Protein Production.

In 2009, an estimated xxx million transfection reactions (not counting transfections using viral delivery tools) were conducted at about xx,xxx laboratories around the world. The majority of these reactions--roughly xx%--were conducted using commercial transfection reagents: kit-based cationic lipids, dendrites, or other chemicals from vendors such as Life Technologies, Roche Applied Science, and Qiagen. Electroporation is the next most widely employed transfection technology, used for approximately xx% of transfection reactions.
Finally, "homebrew reagents"--stock chemicals such as calcium phosphate--were used for the remaining xx% of transfection reagents.
While commercial transfection reagents are employed for the majority of reactions, the global transfection market is undergoing a major shift; electroporation is overtaking commercial reagents as the primary driver of market growth. As recently as five years ago, commercial transfection reagents were outgrowing electroporation. In 2005, for example, the commercialization of optimized reagents for the transfection of small interfering ribonucleic acids (siRNA) allowed for market growth to exceed xx%. Despite continued double-digit growth in RNA interference (RNAi) and protein production applications, the market for commercial transfection reagents is only expected to grow with a x.x% compound annual growth rate (CAGR) from 2009 to 2016.
Today, the demand for solutions that enable efficient transfection in primary cells is resulting in an electroporation market that is forecast to grow with a xx.x% CAGR between 2009 and 2016. Electroporation market growth is attributable to biomedical researchers' (customers') increasing average investment per reaction, which is forecast to grow from approximately $x.xx in 2009 to $x.xx in 2016. In 2009, approximately x.x million electroporation-based transfections cost more than $xx per reaction. In 2016, more than x.x million electroporation-based transfections are likely to cost more than $xx per reaction.
The global sales of transfection products generated $xxx million in revenue in 2009 with a growth rate of x.x% from 2008 revenues. The total global transfection market is forecast to grow at a CAGR of x.x% from 2009 to 2016, reaching $xxx million in revenue in 2016.

Scope and Segments

This research service covers the global transfection market, with the base year as 2009. The forecast values for the total market include revenues generated from the sales of commercial transfection reagents, electroporation products, homebrew reagents, and viral delivery tools.

The study period for this research service is from 2006 to 2016. Market sizing and revenue forecasts are provided for four technology segments and three application segments:

Te c h n o l o g y S e g m e n t s

Commercial Transfection Reagents Market
The commercial transfection reagents market includes global revenues generated from the sales of kits and reagents commercialized for transfection. These reagents are generally sold in volumes that range from x.x mL (xxx reactions) to xx.x mL (xxx reactions). Products are often optimized for applications involving cell lines (e.g. specific for xx cells or CHO cells), primary cells, stem cells, RNAi (e.g. transfection of siRNAs or microRNA mimics and inhibitors), and protein production. Per reaction, product costs range from xx cents to $x.

Electroporation Market

The electroporation market includes global revenues generated from the sales of electroporation instrumentation and accessories, consumables, kits, and buffers. Instrumentation can range in cost from $x,xxx to $xx,xxx. Accessories, including cables, connectors, adapters, electrodes, shuttles, controller modules, cuvette chambers, and pipettes, can range in price from a few dollars to thousands of dollars. Consumables, including plates and cuvettes, range in cost from $x to $xxx. Generic electroporation buffers cost approximately $xx per mL and optimized electroporation kits cost approximately $xx per reaction. Given the common reuse of consumables, per reaction costs (including instrumentation) can vary from as little as 30 cents to more than $xx.

Homebrew Transfection Reagents Market
The homebrew transfection reagents market includes global revenues generated from the sales of salts, solutions, and buffers for the homebrew preparation of transfection reagents. Primary products include calcium chloride dehydrate (xx cents per gram), sodium phosphate dibasic (xx cents per gram), and HEPES buffer (xx cents per gram).

The viral delivery tools market includes global revenues primarily generated from the sales of adenoviral and lentiviral vectors for viral-mediated transduction. Viral expression kits, which generally include vectors, controls, and purification consumables, can cost hundreds to thousands of dollars. Viral delivery involves a fixed investment and, therefore, parity exists on a per reaction or per transfection basis with other transfection methods.

A p p l i c a t i o n S e g m e n t s

Transfection Market for Gene and Protein Expression
Revenues generated from sales of transfection technologies--employed in the expression of a gene of interest followed by analysis of resulting protein function--are counted towards the transfection market for gene and protein expression. The primary aim of the application is to determine the effect of gene expression and resulting protein function on specific cellular pathways and mechanisms. Transfection revenues generated from applications that just involve the expression of a gene without downstream protein analysis are also counted towards this market.

Transfection Market for RNA Interference (RNAi)
Revenues generated from the sales of transfection technologies employed to silence the expression of target genes using RNAi technologies are counted towards the transfection market for RNA Interference. Any applications that involve the transfection of siRNAs, short-hairpin (sh)RNAs, and micro(mi)RNAs are counted towards this market.

Transfection Market for Protein Production
Revenues generated from the sales of transfection technologies employed for rapid and high-yield protein production are counted towards the transfection market for protein production. The primary aim of the application is in early preclinical development of therapeutic proteins.

Low- versus High-value Transfections
The transfection market can also be segmented based on the difficulty associated with transfection.
The low-value market applies to relatively easy transfections costing less than $xx per reaction, while the high-value market applies to difficult transfections costing $xx or more per reaction.

Research Methodology
The majority of the quantitative and qualitative information contained in the following research was acquired though primary research obtained from providers of transfection products. Industry-specific information obtained includes

  • Transfection revenue breakdowns by market segments
  • Projected growth rates of various competitors
  • Top-level market information, including market and technology trends
  • Market drivers and restraints
  • Industry challenges and strategic recommendations
  • Company revenues and market share

Most consultations were conducted with product managers, marketing managers, marketing directors and business development directors of various participants in the transfection markets.
Supplementary research was conducted using secondary sources, including

  • Scientific journals
  • Online media
  • Frost & Sullivan databases and research services
  • Publicly available corporate filings
  • Newsletters

Forecasts were based on the data and analyses regarding industry challenges, market drivers and restraints, and market trends. If specific revenues or market sizes were unavailable, estimates were derived through consultations with industry experts, augmented by secondary research. Growth trends specific to certain market participants are based on consultations, past growth rates, and technology reviews.

C h a p t e r 1
Executive Summary
Market Overview
Introduction
C h a p t e r  2
Total Transfection Market
Market Overview
Introduction
Scope and Segments
Technology Segments
Application Segments
Research Methodology
Market Engineering Measurements
Market Drivers and Restraints
Market Drivers
Increased Focus on Difficult-to-transfect Cells Spurs Demand for High-value
Electroporation Technologies
High Throughput Screening Employing RNAi Technologies Accelerates Consumption
of Commercial Transfection Reagents
Stimulus Funding for Instrumentation and System Solutions Indirectly Drives the Transfection Market
Protein Production Promotes Use of Transient Transfection Methods
Emerging Biopharmaceutical Markets in Asia Boost Transfection Needs
Market Restraints
Decreased Spending Following Global Economic Downturn Limits Transfection Market Growth
Declining Funding for Pharmaceutical Research Slows Growth of the Transfection Market
for RNAi and Protein Production Applications
High Manufacturing Costs Prevent Sufficient Price Decreases Needed for Rapid Market Expansion
Continued Use of Homebrew Reagents for Protein Production Limits Sales of Commercial
Transfection Reagents that are Optimized for this Application
Disappearing Need for Electroporation in Large-scale Sequencing Facilities Decreases
Market Opportunity
Technology and Market Trends
Technology Trends
Transfection Technologies for Stem Cell Research
MicroRNA as Subsegment of the Transfection Market for RNAi Applications
Market Trends
Degree of Transfection Technology Implementation
Cross-functional Biomedical Research Laboratories in Academia
Employing a Transfection Technology Arsenal
Market Forecasts and Competitive Analysis
Revenue Forecasts
Total Transfection Market
Commercial Transfection Reagents Market
Electroporation Market
Viral Delivery Transfection Market
Homebrew Transfection Reagents Market
Competitive Structure
Competitive Metrics
Competitive Metrics Description
Market Share Analysis
Mergers & Acquisitions
Market Challenges and Strategic Recommendations
Industry Challenges
Lack of Technology to Facilitate Efficient Transfection of Hard-to-transfect Cells
Commoditization of Transfection Products Restrains Market Growth
Transfections Enabled by Low-cost Solutions Prevent Rapid Market Expansion
Prominent Use of Homebrew Methods Restrains the Transfection Market
Strategic Recommendations
Develop New Technologies and Product Improvements
Develop Optimized Electroporation Solutions to Address Difficult Transfections
Provide Specialized Products for Emerging High-Growth Market Segments
Offer Broad Product Portfolio to Address a Varied Customer Base
Target the Market for Both Low- and High-value Transfections
Continually Enhance Portfolio of Products for Stem Cell Research Transfection
Offer Customers Solutions for both “One-size-fits-all” Transfection as well as Targeted Transfection

List of Figures
C h a p t e r
Total Transfection Market
2-1 Transfection Market:
Market Drivers Ranked in Order of Impact (World), 2010-2016
2-2 Transfection Market:
Market Restraints Ranked in Order of Impact (World), 2010-2016
2-3 Transfection Market:
Revenue Forecasts (World), 2006-2016
2-4 Commercial Transfection Reagents Market:
Revenue Forecasts (World), 2006-2016
2-5 Electroporation Market:
Revenue Forecasts (World), 2006-2016
2-6 Viral Delivery Market:
Revenue Forecasts (World), 2006-2016
2-7 Homebrew Transfection Reagents Market:
Revenue Forecasts (World), 2006-2016
2-8 Transfection Market:
Percent of Revenues by Technology Segment (World), 2006-2016
2-9 Transfection Market:
Percent of Revenues by Application Segment (World), 2009
2-10 Transfection Market:
Competitive Structure (World), 2009
2-11 Transfection Market:
Competitive Metrics (World), 2009
2-12 Transfection Market:
Company Market Share by Revenues (World), 2009
2-13 Transfection Market:
Impact of Top Industry Challenges (World), 20010-2016
2-14 Transfection Market:
Challenges and Corresponding Strategic Recommendations (World), 2010-2016

List of Charts
C h a p t e r
Total Transfection Market
2.1 Transfection Market:
Market Engineering Measurements (World), 2009
2.2 Transfection Market:
Degree of Implementation across Five End User Segments (U.S.), 2010
2.3 Transfection Market:
Revenue Forecasts (World), 2006-2016
2.4 Commercial Transfection Reagents Market:
Revenue Forecasts (World), 2006-2016
2.5 Electroporation Market:
Revenue Forecasts (World), 2006-2016
2.6 Viral Delivery Market:
Revenue Forecasts (World), 2006-2016
2.7 Homebrew Transfection Reagents Market:
Revenue Forecasts (World), 2006-2016
2.8 Transfection Market:
Revenue Forecast by Technology Segment (World), 2006-2016
2.9 Transfection Market:
Revenue Growth by Technology Segment (World), 2007-2016
2.10 Transfection Market:
Percent of Revenues by Technology Segment (World), 2006-2016
2.11 Transfection Market:
Percent of Revenues by Technology Segment (World), 2009
2.12 Transfection Market:
Percent of Revenues by Application Segment (World), 2009
2.13 Transfection Market:
Competitive Metrics (World), 2009
2.14 Transfection Consumables Market:
Market Share Analysis (World), 2009
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