- PDF: Delivered by email within 12 to 24 hours of placing the order (Mon-Fri)
Androgen Receptor Signaling Pathway in Oncology Drug Pipeline Update
2013
- Product Code:BSK00514
- Publication Date:April 2013
- Publisher:Bioseeker
- Product Type: Report
Androgen Receptor Signaling Pathway in Oncology Drug Pipeline Update 2013
The Alpha6 Beta4 Integrin signaling pathway activates the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules.
There are today 228 companies plus partners developing 321 Alpha6Beta4 integrin pathway targeting drugs in 1113 developmental projects in cancer. In addition, there is 1 suspended drug and the accumulated number of ceased drugs over the last years amount to another 134 drugs. Alpha6 Beta4 Integrin Signaling Pathway In Oncology Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 131 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 120 out of the 130 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 32 classifications of molecular function and with pathway referrals to BioCarta, KEGG. NCI-Nature and NetPath.
How May Drug Pipeline Update Be of Use'
- Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
- Find competitors, collaborations partners, M&A candidates etc.
- Jump start competitive drug intelligence operationw
- Excellent starting point for world wide benchmarkinw
- Compare portfolio and therapy focus with your peerw
- Speed up pro-active in-/out licensing strategy worw
- Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.
Drug Pipeline Update at a Glance
Investigators
Includes more than 228 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
Note: You are able to sort and find drugs according to companiess and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.
Drug name & Synonyms
Lists commercial, generic and code names for drugs.
Developmental stage
This Drug Pipeline Update contains 321 Alpha6Beta4 integrin pathway targeting drugs in development, which have a total of 1113 developmental projects in cancer. In addition there are suspended and ceased drugs.
Pipeline Breakdown According to Number of Drugs
Marketed# 29
Registered# 1
Pre-registration# 3
Phase III# 33
Phase II# 101
Phase I# 130
Preclinical# 194
No Data# 1
Suspended# 1
Ceased# 134
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.
Indications
Included Alpha6Beta4 integrin pathway targeting drugs are also in development for 118 other indications, where of 83 are different cancer indications.
Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.
Targets
Mutations
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 120 out of the 130 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.
Biological Structures
The identity of available biological structures on 109 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 2216 structures available today among drug targets.
Identified drugs are linked to more than 131 different targets, divided into 32 classifications of molecular function:
- Antigen binding
- Catalytic activity
- Cell adhesion molecule activity
- Chaperone activity
- Cysteine-type peptidase activity
- Cytokine activity
- DNA binding
- G-protein coupled receptor activity
- Glutathione transferase activity
- Growth factor activity
- GTPase activity
- Isomerase activity
- Kinase activity
- Kinase binding
- Ligand-dependent nuclear receptor activity
- Lipid kinase activity
- Lipid phosphatase activity
- Peroxidase activity
- Protein binding
- Protein serine/threonine kinase activity
- Protein tyrosine phosphatase activity
- Protein-tyrosine kinase activity
- Receptor activity
- Receptor signaling complex scaffold activity
- Receptor signaling protein tyrosine phosphatase activity
- Structural constituent of cytoskeleton
- Structural molecule activity
- Transcription factor activity
- Transcription regulator activity
- Translation regulator activity
- Transmembrane receptor protein tyrosine kinase activity
- Transporter activity
Sub-Cellular Localization
Identified targets are categorized into 24 different primary and alternate sub-cellular localizations:
- Cell projection
- Centrosome
- Chromosome
- Clathrin-coated vesicle
- Cytoplasm
- Cytoplasmic vesicle
- Cytoskeleton
- Cytosol
- Endoplasmic reticulum
- Endosome
- Extracellular
- Golgi apparatus
- Lysosome
- Mitochondrion
- Nuclear membrane
- Nucleolus
- Nucleus
- Perinuclear region
- Perinuclear vesicle
- Plasma membrane
- Ribosome
- Sarcoplasmic reticulum
- Secreted
- Vesicle
Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.
Target Expression Profile
Direct links are provided from inside the application to 211 protein expression profiles of 123 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:
- 48 different normal tissue types
- 20 different types of cancer
- 47 cell lines
- 12 samples of primary blood cells
Pathway Referrals
Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.
- BioCarta# 206 Pathways
- KEGG# 129 Pathways
- NCI-Nature# 238 Pathways
- NetPath# 25 Pathways
Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.
Mechanism
In total there are different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.
Compound
Identified drug compounds are described by:
Compound type, Chemical name, CAS Number and molecular weightNote: You are able to sort and find drugs according to compound type from drop-down menu in the application.
Drug Profile
Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:
Drug Name & Synonyms
Presentation of drug name and synonyms
Principal Company & Partners
Presentation of principal company and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol ' Chromosome Location ' Gene & Protein Name ' Molecular Function
Target Localization
Described target(s) is/are presented with primary and alternate localizations.
Target Expression Profiles
Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells
Mutation
All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.
Biological Structures
The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.
Targeted Pathways
Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.
Mechanism
Drug mechanism of action
Developmental Projects
Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma ' Phase II Clinical Trial ' Active
Cancer, prostate ' Phase III Clinical Trial ' Ceased
Drug Description
Short introduction to drug
Compound Data
Compound type, Chemical name, CAS Number and molecular weightPatent Data
Available patent information related to the drug is presented here.
Fillings and Approvals
Approvals and submissions
Analyst comments
Deals & Licensing
Collaborations and deals
Availability for licensing
Phase IV Data
Available Phase IV development data, developmental history and scientific data.
Phase III Data
Available Phase III development data, developmental history and scientific data.
Phase II Data
Available Phase II development data, developmental history and scientific data.
Phase I Data
Available Phase I development data, developmental history and scientific data.
Phase 0 Data
Available Phase 0 development data, developmental history and scientific data.
Preclinical Data
Available preclinical development data, developmental history and scientific data.
Discovery Data
Available discovery development data, developmental history and scientific data.
Application Features
Search, Find and Filter Panel with Initial Result Presentation
With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
Direct linkage from inside the application to related internet resources
- Drug data is linked to search engines like Google and PubMed
- Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
- Direct links to company web pages of companies
Dynamic Report Generator
Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.
System Requirements
- Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion)
- Browser Application (Internet Explorer)
- Internet access (to access related internet resources)
There is no table of contents for this product
