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Protein Kinase Inhibitors in Oncology Drug Pipeline Update
2013

  • Publication Date:April 2013
  • Publisher:Bioseeker
  • Product Type: Report

Protein Kinase Inhibitors in Oncology Drug Pipeline Update 2013

Cancer of the prostate is the second most frequently diagnosed cancer in men in the US. The prostate cancer market is reaching maturity, and major players` sales have been eroded by the launch of various LHRH agonist depot formulations. Safety concerns with AstraZeneca`s Casodex (bicalutamide) have also seen a significant proportion of physicians switching to alternatives. Establishing the optimal timing of antihormonal therapy will provide the key to market growth.
There are today 333 companies plus partners developing 402 drugs targeting prostate cancer in development. In addition, there are 6 suspended drugs and the accumulated number of ceased drugs over the last years amount to another 175 drugs. Prostate Cancer Drug Pipeline Update lists all drugs and gives you a progress analysis on each one of them. Identified drugs are linked to 259 different targets. All included targets have been cross-referenced for the presence of mutations associated with human cancer. To date 226 out of the 253 studied drug targets so far have been recorded with somatic mutations. The software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information. All drugs targets are further categorized on in the software application by 64 classifications of molecular function and with pathway referrals to BioCarta, KEGG. NCI-Nature and NetPath.

How May Drug Pipeline Update Be of Use'

  • Show investors/board/management that you are right on top of drug development progress in your therapeutic area.
  • Find competitors, collaborations partners, M&A candidates etc.
  • Jump start competitive drug intelligence operationw
  • Excellent starting point for world wide benchmarkinw
  • Compare portfolio and therapy focus with your peerw
  • Speed up pro-active in-/out licensing strategy worw
  • Fast and easy way of tracking drugs using search engines; just one click from inside the application and you may search the World Wide Web and PubMed for any drug. Drug Pipeline Update is delivered to you as a downloadable application, which requires no installation on your computer. Please read more about application features and system requirements below.

Drug Pipeline Update at a Glance

Investigators

Includes more than 333 principal companies plus their collaborators. There is direct access from inside the application to web pages of all principal companies.
Note: You are able to sort and find drugs according to companiess and partners from drop-down menus in the application. You may also sort and find drugs according to country of companies.

Drug name & Synonyms

Lists commercial, generic and code names for drugs.

Developmental stage

This Drug Pipeline Update contains 402 drugs in development for the treatment of prostate cancer. In addition there are suspended and ceased drugs.
Pipeline Breakdown According to Number of Drugs
Marketed# 29
Pre-registration# 2
Phase III# 20
Phase II# 153
Phase I# 76
Preclinical# 118
No Data# 4
Suspended# 6
Ceased# 175
Note: You are able to sort and find drugs according to developmental stage from drop-down menu in the application.

Indications

Included prostate cancer drugs are also in development for 199 other indications, where of 97 are different cancer indications.
Note: You are able to find and sort drugs according to type of indication from drop-down menu in the application.

Targets

Mutations

All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers. To date 226 out of the 253 studied drug targets so far have been recorded with somatic mutations and the software application lets you narrow in on these mutations and links out to the mutational analysis for each of the drug targets for detailed information.

Biological Structures

The identity of available biological structures on 178 drug targets was retrieved from the RCSB Protein Databank for you to easily review the 3329 structures available today among drug targets.
Identified drugs are linked to more than 259 different targets, divided into 64 classifications of molecular function:

  • Acid phosphatase activity
  • Aminopeptidase activity
  • Auxiliary transport protein activity
  • Calcium ion binding
  • Carboxy-lyase activity
  • Carboxypeptidase activity
  • Catalytic activity
  • Cell adhesion molecule activity
  • Chaperone activity
  • Chemokine activity
  • Complement activity
  • Cysteine-type peptidase activity
  • Cytokine activity
  • Deaminase activity
  • DNA binding
  • DNA repair protein
  • DNA topoisomerase activity
  • DNA-directed DNA polymerase activity
  • Extracellular ligand-gated ion channel activity
  • Extracellular matrix structural constituent
  • G-protein coupled receptor activity
  • Growth factor activity
  • GTPase activator activity
  • Hormone activity
  • Hydrolase activity
  • Intracellular ligand-gated ion channel activity
  • Ion channel activity
  • Isomerase activity
  • Kinase activity
  • Ligand-dependent nuclear receptor activity
  • Ligase activity
  • Lipid kinase activity
  • Lipid phosphatase activity
  • Metallopeptidase activity
  • MHC class I receptor activity
  • Molecular function unknown
  • Motor activity
  • Oxidoreductase activity
  • Peptide hormone
  • Peroxidase activity
  • Phosphoric diester hydrolase activity
  • Protein binding
  • Protein serine/threonine kinase activity
  • Protein tyrosine phosphatase activity
  • Protein-tyrosine kinase activity
  • Receptor activity
  • Receptor binding
  • Receptor signaling complex scaffold activity
  • Receptor signaling protein serine/threonine kinase activity
  • RNA binding
  • RNA-directed DNA polymerase activity
  • Serine-type peptidase activity
  • Structural constituent of cytoskeleton
  • Superoxide dismutase activity
  • Transcription factor activity
  • Transcription regulator activity
  • Transferase activity
  • Translation regulator activity
  • Transmembrane receptor activity
  • Transmembrane receptor protein tyrosine kinase activity
  • Transporter activity
  • Ubiquitin-specific protease activity
  • Unknown
  • Voltage-gated ion channel activity

Sub-Cellular Localization

Identified targets are categorized into 28 different primary and alternate sub-cellular localizations:

  • Cell junction
  • Cell surface
  • Centrosome
  • Chromosome
  • Clathrin-coated vesicle
  • Cytoplasm
  • Cytoplasmic vesicle
  • Cytoskeleton
  • Cytosol
  • Endoplasmic reticulum
  • Endosome
  • Extracellular
  • Golgi apparatus
  • Integral to membrane
  • Lysosome
  • Microtubule
  • Mitochondrial membrane
  • Mitochondrion
  • Nuclear membrane
  • Nucleolus
  • Nucleus
  • Perinuclear region
  • Perinuclear vesicle
  • Peroxisome
  • Plasma membrane
  • Sarcoplasmic reticulum
  • Secreted
  • Secretory granule

Note: You are able to find and sort drugs according to target gene name, protein name, molecular function of target, target localization, presence of mutations and availability of biological structures of target from drop-down menus in the application.

Target Expression Profile

Direct links are provided from inside the application to 372 protein expression profiles of 228 drug targets in various human tissues and cancer types, cell lines and primary cells, including up to:

  • 48 different normal tissue types
  • 20 different types of cancer
  • 47 cell lines
  • 12 samples of primary blood cells

Pathway Referrals

Identified targets have been cross referenced against their involvement in different cellular pathways, according to BioCarta, KEGG, NCI-Nature and NetPath.

  • BioCarta# 240 Pathways
  • KEGG# 172 Pathways
  • NCI-Nature# 235 Pathways
  • NetPath# 25 Pathways

Note: You are able to find and sort drugs according to targeted pathways from drop-down menus in the application.

Mechanism

In total there are different drug mechanism of action represented in this Drug Pipeline Update.
Note: You are able to find and sort drugs according to mechanism of action from drop-down menu in the application.

Compound

Identified drug compounds are described by:

Compound type, Chemical name, CAS Number and molecular weight

Note: You are able to sort and find drugs according to compound type from drop-down menu in the application.

Drug Profile

Progress analysis and review of drug development. A typical drug profile reports on, depending on stage of development and available information:

Drug Name & Synonyms

Presentation of drug name and synonyms

Principal Company & Partners

Presentation of principal company and partners
Target and Molecular Function of Target
Described target(s) is/are presented with:
Official Gene Symbol ' Chromosome Location ' Gene & Protein Name ' Molecular Function

Target Localization

Described target(s) is/are presented with primary and alternate localizations.

Target Expression Profiles

Links to protein expression profile(s) of target(s) in various human tissues, cell lines and primary cells, including up to:
48 different normal tissue types
20 different types of cancer
47 cell lines
12 samples of primary blood cells

Mutation

All targets are cross-referenced with the Catalogue of Somatic Mutations in Cancer (COSMIC). It is designed to store and display somatic mutation information and related details and contains information relating to human cancers.

Biological Structures

The identity of available biological structures on drug targets was retrieved from the RCSB Protein Databank for you to easily review what available structures of drug targets exist.

Targeted Pathways

Described target(s) is/are matched for the involvement in cellular pathways according to BioCarta, KEGG, NCI-Nature and NetPath.

Mechanism

Drug mechanism of action

Developmental Projects

Summary field of developmental projects for the drug, including indication, developmental stage and status.
Example:
Cancer, myeloma ' Phase II Clinical Trial ' Active
Cancer, prostate ' Phase III Clinical Trial ' Ceased

Drug Description

Short introduction to drug

Compound Data

Compound type, Chemical name, CAS Number and molecular weight

Patent Data

Available patent information related to the drug is presented here.

Fillings and Approvals

Approvals and submissions
Analyst comments

Deals & Licensing

Collaborations and deals
Availability for licensing

Phase IV Data

Available Phase IV development data, developmental history and scientific data.

Phase III Data

Available Phase III development data, developmental history and scientific data.

Phase II Data

Available Phase II development data, developmental history and scientific data.

Phase I Data

Available Phase I development data, developmental history and scientific data.

Phase 0 Data

Available Phase 0 development data, developmental history and scientific data.

Preclinical Data

Available preclinical development data, developmental history and scientific data.

Discovery Data

Available discovery development data, developmental history and scientific data.

Application Features

Search, Find and Filter Panel with Initial Result Presentation
With this panel you can define your selectivity in each drug search with up to 24 different drug specific parameters. Each parameter has multi-select options to them and can be used as either an inclusion parameter or exclusion parameter.
The initial result table is a dynamic sortable table which gives you a fast overview of found results and can be narrowed down further by your own additional keywords.
Direct linkage from inside the application to related internet resources

  • Drug data is linked to search engines like Google and PubMed
  • Drug target data is linked directly to BioCarta, Human Protein Atlas, KEGG, NCI-Nature, NetPath etc.
  • Direct links to company web pages of companies

Dynamic Report Generator

Our dynamic report generator lets you with ease and speed generate html reports directly in your web browser (Internet Explorer and FireFox), whether it is a single drug profile or an entire search you want have a report of.

System Requirements

  • Operating system: Windows (2000/XP/Vista/7) and Mac OS X 10.6 (Snow Leopard) and OS X 10.7 (Lion)
  • Browser Application (Internet Explorer)
  • Internet access (to access related internet resources)

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