Bioinformatics

Technical Status and Market Prospects

Publication Date	August 2005
Publisher	BCC Research
Product Type	Report
Pages	161
ISBN Number
Product Code	BCC00113

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Summary

Bioinformatics is a set of enabling technologies responsible for the annotation, storage, analysis and search/retrieval of nucleic acid sequence, protein sequence and structural information. This includes integration of the information on the sequences and structures of nucleic acids and proteins into databases such as EMBL, as well as methods to access, search, model and analyze this information.

This BCC study examines the current status of the worldwide bioinformatics industry and assesses its growth potential over a six-year period to 2010. Of particular interest is the value added by bioinformatics in the process of drug discovery and development. Also examined are various technologies and patenting trends in the industry. In addition, market potential for emerging bioinformatics applications such as gene therapy, molecular medicine, etc. is assessed.

Primary focus is on the application of bioinformatics to the process of drug discovery and development, the major user of the technology. Worldwide activity in this sector was considered for this report.

Scope Of Study

The report contains:

Technological descriptions of, and patenting trends in bioinformatics
Examination of the economic environment impacting the deployment of bioinformatics
Analysis of market factors and the worldwide potential of bioinformatics through 2010
Analysis of the basis of products, applications and geographic presence
Discussion of other influential factors such as R&D spending in the pharmaceutical sector, the growth of agrobiotechnology, and the expanded use of microbial genomics.

Report Highlights

The worldwide value of bioinformatics is expected to increase from $1.02 billion in 2002 to $3.0 billion in 2010, at an average annual growth rate (AAGR) of 15.8%.
The fastest growing market is expected to be analysis software and services. It is estimated to grow from $444.7 million in 2005 to $1.2 billion in 2010.
The application of bioinformatics in drug discovery and development is expected to reduce the annual cost of developing a new drug by 33%, and the time for drug discovery by 30%.
The pharmaceutical companies are expected to increase their R&D expenditures in the future and a major portion of this spending is expected to go into bioinformatics.

Content

Introduction
- Goals And Objectives
- Reasons For Doing The Study
- Contribution Of The Study And For Whom
- Scope And Format
- Methodology
- Information Sources
- Related BCC Reports
- BCC On-Line Services
- Internet
Executive Summary
- Summary Table: Worldwide Value Of Bioinformatics Market, Through 2010 ($ Millions)
- Summary Figure: Worldwide Value Of Bioinformatics Market, 2002-2010 ($ Millions)
Overview
- Industry Definition
- Bioinformatics In Biotechnology
- Concepts In The Industry
  - Genomics
  - Proteomics
  - Pharmacogenomics
  - Cheminformatics
- Technology Development
- History And Development Of Industry
- Description Of Major Technologies/Applications
  - Bioinformatics In Drug Discovery And Development
  - Life Cycle Of A Drug
- Foreseeable Future Developments
  - Emergence Of New Technologies
    - Image Informatics
    - Microarray Data Production
    - In Silico Biology
    - Protein Folding Computation
    - Translational Research
    - Influence Of Genomics Versus Proteomics
    - Metabolomics And The Central Dogma Of Molecular Biology
    - Future Trends In Bioinformatics
Markets By Product
- Key Functions
- Suppliers
- End-Users
- Industry Dynamics
- Total Market Size
- Product Categories
  - Content
    - Description And Market Size By Database
    - Generalized Databases
    - Specialized Databases
    - Description And Market Size By Field Of Study
    - Genomics Based
    - Dna Sequence
    - Gene Expression
    - Proteomics Based
    - Protein Sequence
    - Protein Structure
    - Protein-Protein Interaction
    - Pharmacogenomics Based
    - Snp Databases
    - Cheminformatics Based
    - Compound Libraries
  - Analysis Software And Services
    - Description
    - Genomics And Proteomics Based
    - Sequence Analysis And Comparison Software
    - Blast
    - Transeq
    - Clustalw
    - Staden Package
    - Molecular Imaging/Modeling Programs
    - Rasmol
    - Structural Analysis/Prediction Software
    - Threader
    - Modeller
    - Swiss Pdb Viewer
    - Pharmacogenomics Based
    - Dchipsnp
    - Genorama Genotyping Software
    - Cheminformatics Based
    - Derek For Windows
    - Maccs
  - It Infrastructure And Services
    - Description
    - Supercomputers
    - Clusters
    - Multiprocessor Servers
    - Alternative Classification Of It Infrastructure By Fields Of Study
    - Growth Drivers
    - Shotgun Sequencing
    - Tandem Ms
    - High Throughput Screening (HTS)
    - Microarrays
    - In Silico Modeling
    - Inhibitors
Markets By End-User
- Total Market Size
- Drug Discovery And Development
  - Application Description
  - Drug Discovery Phase
    - Target Identification
    - Target Validation
    - Lead Identification
    - Lead Optimization
  - Drug Development Phase
    - Preclinical Experiments
    - Investigational New Drug Application (IND)
    - Clinical Trials
    - New Drug Application
    - Nda Approval
  - Market Drivers For Bioinformatics
    - High Cost Of Drug Discovery And Development
    - Patent Expiration
    - Need To Reduce Time In Drug Discovery Process
    - Innovation And Technology In Key Areas Of Drug Discovery And Development
    - Clinical Genomics
    - Pharmacogenomics
    - Proteomics
- Molecular Medicine
  - Application Description
    - Pharmacogenomics And Personalized Medicine
    - Advantages
    - Disadvantages
    - Gene Testing And Preventive Medicine
    - Advantages
    - Disadvantages
    - Gene Therapy
    - Advantages
    - Disadvantages
    - Niche Markets
- Microbial Genome Applications
  - Application Description
    - Radioactive Waste Cleanup
    - Climate Change
    - Alternative Energy Sources
    - Antibiotic Resistance
    - Criteria For Drug Targets
    - Primary Sequence Comparison Programs
    - Cluster Analysis
    - Structural Genomics
    - Forensic Analysis Of Microbes
    - Evolutionary Studies
- Agricultural Applications
  - Application Description
- Comparative Studies
Markets By Region
- Market Size
  - United States
  - Europe
  - Asia Pacific
    - Japan
    - India
    - Australia
    - Singapore
    - South Korea
Technology Overview
- Technology And Tools
  - Software
    - Mysql
    - Corba Clients
    - Cvs
    - Php
    - Bioperl
    - Biojava
    - Biopython
    - Xml
- Modes Of Data Integration
  - Application Service Provider
    - Advantages
    - Disadvantages
    - Key Drivers
  - Data Pipelining
    - Advantages
    - Disadvantages
  - Data Warehousing
    - Advantages
- Key Developments
- Patent Overview
  - Patent Types
  - Analysis Of Patents By Field Of Study
    - Genomics Patents
    - Proteomics Patents
    - Pharmacogenomics Patents
    - Cheminformatics Patents
  - Analysis Of Patents By Major Filers
    - Genomics Patents
    - Proteomics Patents
    - Pharmacogenomics Patents
    - Cheminformatics Patents
  - Analysis Of Patents By Region
    - Genomics Patents
    - Proteomics Patents
    - Pharmacogenomics Patents
    - Cheminformatics Patents
- Abstracts Of Relevant Patents By Field Of Study
  - Genomics
    - Synthetic Tag Genes
    - Complexity Management Of Genomic Dna By Locus Specific Amplication
    - Method For Analyzing A Nucleic Acid
  - Proteomics
    - Proteomic Analysis
    - Methods Of Obtaining Isoform Specific Expression In Mammalian Cells
  - Pharmacogenomics
    - Human Polypeptides Encoded By Polynucleotides And Methods Of Their Use
  - Cheminformatics
    - Method And System For Extracting Data From Surface Array Deposited Features
    - Molecular Nephrotoxicology Modeling
    - System And Method For Chemical Process Scale-Up And Preliminary Design And Analysis
    - Methods And Systems For Annotating Biomolecular Sequences
Industry Structure And Competitive Analysis
- Industry Overview
  - Industry Growth Curve
  - Product Segments
  - Regional Markets
  - Bioinformatics Analysts
  - Drivers For The Industry
    - Need To Analyze Biological Data
    - Need For Enhanced Automation In Drug Discovery And Development
  - Industry Challenges
    - Software Standardization And Data Integration
    - High-Performance Computing
    - Lack Of Skill-Sets
    - Ethical And Social Issues
  - Application Software From Independent Software Providers (ISPS)
    - It Infrastructure
    - End Users
    - Pharmaceutical Companies
    - Biotechnology Companies
    - Academic Institutions And Research Groups
  - Models
    - Application Service Providers Model
    - Software Licenses And Maintenance Fees Model
    - Research Collaboration Model
- Present And Future Trends In The Bioinformatics Industry
  - Outsourcing Trends In Industry
- Industry Structure
  - Threats Of New Entrants
  - Bargaining Power Of Buyers
  - Bargaining Power Of Suppliers
  - Inter-Industry Competition
  - Threats Of Substitutes
  - Mergers, Acquisitions And Alliances In The Bioinformatics Industry
  - Government Grants
- Profiles Of Companies
  - Accelrys
  - Affymetrix
  - Agilent Technologies
  - Amersham Biosciences
  - Celera
  - Compugen
  - Curagen
  - Gene Logic
  - Geospiza
  - Ibm Life Sciences
  - Incyte
  - Lion Bioscience Ag
  - Silicon Graphics
  - Tripos
Appendices
- List Of Similarity Search Tools Provided By The European Bioinformatics Institute (EBI)
  - Dna And Protein Searches
  - Rigorous Protein Searches
  - Specialized Dna Searches
- List Of Sequence Analysis Tools Provided By European Bioinformatics Institute (EBI)
List Of Figures
- Summary Table: Worldwide Value Of Bioinformatics Market, Through 2010 ($ Millions)
- Table 1 Worldwide Market For Bioinformatics, By Fields Of Study, Through 2010 ($ Millions)
- Table 2 Worldwide Market For Genomics, Through 2010 ($ Millions)
- Table 3 Worldwide Market For Proteomics, Through 2010 ($ Millions)
- Table 4 Worldwide Market For Pharmacogenomics, Through 2010 ($ Millions)
- Table 5 Worldwide Market For Cheminformatics, Through 2010 ($ Millions)
- Table 6 R&d Expenditure On Drug Discovery And Development, Through 2005 ($ Millions)
- Table 7 Life Cycle Of A Drug
- Table 8 Worldwide Bioinformatics Market, By Product, Through 2010 ($ Millions)
- Table 9 Worldwide Bioinformatics Content Market By Database Type, Through 2010 ($ Millions)
- Table 10 Worldwide Generalized Database Market By Type Of Content, Through 2010 ($ Millions)
- Table 11 Sample List Of Major Generalized Bioinformatcs Databases
- Table 12 Worldwide Specialized Database Market By Type Of Content, Through 2010 ($ Millions)
- Table 13 Sample List Of Major Specialized Bioinformatics Databases
- Table 14 Worldwide Bioinformatics Content Market By Field Of Study, Through 2010 ($ Millions)
- Table 15 Worldwide Bioinformatics Market By Genomics Content, Through 2010 ($ Millions)
- Table 16 Worldwide Bioinformatics Market By Proteomics Content, Through 2010 ($ Millions)
- Table 17 Worldwide Bioinformatics Market By Pharmacogenomics Content, Through 2010 ($ Millions)
- Table 18 Worldwide Bioinformatics Market By Cheminformatics Content, Through 2010 ($ Millions)
- Table 19 Worldwide Market For Analysis Software And Services Employed In Bioinformatics, By Field Of Study, Through 2010 ($ Millions)
- Table 20 Worldwide Analysis Software And Services Employed In Genomics And Proteomics, Through 2010 ($ Millions)
- Table 21 Worldwide Market For Analysis Software And Services Employed In Genomics And Proteomics By Software Category, Through 2010 ($ Millions)
- Table 22 List Of Sample Sequence Analysis Software
- Table 23 List Of Sample Structure Prediction Software/Programs
- Table 24 Worldwide Market For Analysis Software And Services Employed In Pharmacogenomics, Through 2010 ($ Millions)
- Table 25 List Of Sample Snp Analysis Software/Programs
- Table 26 Worldwide Market For Analysis Software And Services Employed In Cheminformatics, Through 2010 ($ Millions)
- Table 27 Worldwide Bioinformatics It Infrastructure And Services Market By Type Of Equipment, Through 2010 ($ Millions)
- Table 28 Components Of A Cluster
- Table 29 Worldwide Market For It Infrastructure And Services Employed In Bioinformatics, By Field Of Study, Through 2010 ($ Millions)
- Table 30 Key Growth Drivers For Bioinformatics Products
- Table 31 Worldwide Market For Bioinformatics By End-User, Through 2010 ($ Millions)
- Table 32 Worldwide Market For Bioinformatics By Drug-Discovery Application, Through 2010 ($ Millions)
- Table 33 Snapshot Of The Drug Development Process
- Table 34 Worldwide Market For Bioinformatics By Drug Development Application, Through 2010 ($ Millions)
- Table 35 Number Of Drugs With Patents Expiring, Grouped By Treatment, 2001-2004
- Table 36 Patent Expirations Due On Blockbuster Drugs, 2004-2008
- Table 37 Worldwide Market For Bioinformatics By Molecular Medicine Application, Through 2010 ($ Millions)
- Table 38 Sample Application Projects Of Bioinformatics Tools And Resources
- Table 39 Microorganisms Involved In Nitrification, Sequenced Using Bioinformatics Tools
- Table 40 List Of Sample Plant Genome Databases
- Table 41 Bioinformatics Market By Region, Through 2010 ($ Millions)
- Table 42 Bioinformatics Market In The U.S., Through 2010 ($ Millions)
- Table 43 Department Of Energy Funding For The Microbial Genome Project, 1997-2004 ($ Millions)
- Table 44 Bioinformatics Market In Europe, Through 2010 ($ Millions)
- Table 45 Bioinformatics Market In Asia Pacific, Through 2010 ($ Millions)
- Table 46 Bioinformatics Market In Japan, Through 2010 ($ Millions)
- Table 47 Major Software Languages Used In Bioinformatics Software And Their Application Areas
- Table 48 Modes Of Data Integration Employed In Bioinformatics Es
- Table 49 Key Historical Developments In Bioinformatics Technologies, 1965-2000
- Table 50 Bioinformatics Patents By Field Of Study In 2003 And 2004
- Table 51 Bioinformatics Patents By Region, 2003 And 2004
- Table 52 Major Mergers, Acquisitions And Alliances In The Bioinformatics Industry
- Table 53 R&d Spending In The National Institute Of Health (NIH)
List Of Figures
- Summary Figure: Worldwide Value Of Bioinformatics Market, 2002-2010 ($ Millions)
- Figure 1 Defining Bioinformatics
- Figure 2 Key Developments In Bioinformatics Technologies, 1990-2010
- Figure 3 Central Dogma Of Molecular Biology And Bioinformatics
- Figure 4 Future Trends In Bioinformatics
- Figure 5 Key Dynamics In Bioinformatics Industry
- Figure 6 Categories Of Bioinformatics Databases And Their Content
- Figure 7 Various Phases In Drug Discovery And Development Process
- Figure 8 Data Warehousing Approach In Bioinformatics Es
- Figure 9 Genomics Patents In 2003-2004 (Number Of Patents)
- Figure 10 Proteomics Patents In 2003-2004 (Number Of Patents)
- Figure 11 Pharmacogenomics Patents In 2003-2004 (Number Of Patents)
- Figure 12 Cheminformatics Patents In 2003-2004 (Number Of Patents)
- Figure 13 Comparison Of Major Filers Of Genomics Patents, 2003-2004 (Number Of Patents)
- Figure 14 Comparison Of Major Filers Of Proteomics Patents, 2003-2004 (Number Of Patents)
- Figure 15 Comparison Of Major Filers Of Pharmacogenomics Patents, 2003-2004 (Number Of Patents)
- Figure 16 Comparison Of Major Filers Of Cheminformatics Patents, 2003-2004 (Number Of Patents)
- Figure 17 Bioinformatics Patents By Region, 2003-2004 (%)
- Figure 18 Genomics Patents By Region, 2003-2004 (%)
- Figure 19 Proteomics Patents By Region, 2003-2004 (%)
- Figure 20 Pharmacogenomics Patents By Region, 2003-2004 (%)
- Figure 21 Cheminformatics Patents By Region, 2003-2004 (%)
- Figure 22 Bioinformatics Industry Growth Curve
- Figure 23 Skill Set Requirements For Bioinformatics Analysts
- Figure 24 Data Analysis As A Challenge For Bioinformatics Researchers
- Figure 25 Bioinformatics Industry-Value Chain
- Figure 26 Comparison Of The Cost And Value Added By Different Models Employed In Bioinformatics Es
- Figure 27 Porter's Five Forces Model Applied To The Bioinformatics Industry