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Kinase Screening & Profiling Trends 2008

Kinase Screening & Profiling Trends 2008

This market report summarizes the results of HTStec's third global pharma and biotech web-based benchmarking survey on kinase screening and profiling carried out in May 2008

The objective was to document current practices and preference in kinase screening and profiling, and to understand future user requirements particularly with respect to the need for outsourced services. The aim was to compile a reference document which could be directly compared relative to HTStec's 2006 report.

The survey looked at in house and oursourced kinase screening and profiling, as practiced in 2008 and predicted for 2010. The following areas were investigated amongst others - therapeutic areas using kinase assays; kinase panel profiling approach, preferred kinase profiling assay technology, technology supplier and outsourced fee for service providers; kinases as a % of R & D spend; interest and requirements for outsourcing kinase primary screening; size of the kinase panels used; use of different tyrosine kinase assay conditions; use of different species variants of kinases; features of a kinase platform of greatest interest to respondents and where kinase service providers should prioritize going forward.

  • Executive Summary
  • Lab Origin of Survey Respondents
  • Geographic Origin of Survey Respondents
  • Organisational Origin of Survey
  • Respondents
  • Respondent Breakdown by Lab Origin & Organisation
  • Makeup of Survey Groupings Used for Data Analysis
  • Job Role of Survey Respondents
  • Therapeutic Areas Using Kinase Assays Today
  • Respondents Approach to Kinase Panel Profiling
  • Proportion of Kinase Profiling Activities Outsourced
  • Preferred In House Kinase Panel Profiling Assay Technology
  • Preferred In House Kinase Panel Profiling Technology Supplier
  • Preferred Outsourced Kinase Panel Profiling Assay Technology
  • Preferred Outsourced Kinase Panel Profiling Fee-For-Service Supplier
  • Most Trusted Outsourced Kinase Panel Profiling Fee-For-Service Supplier
  • Role of Binding Assays in Kinase Profiling
  • Main Criteria for Selecting an Outsourced Kinase Profiling Supplier
  • What Kinase Service Providers Should Implement to Drive Decision Making
  • Kinase Panel Profiling Budgets
  • Percentage of R&D Budget Allocated To Kinases
  • In House Kinase Profiling Budget Vendor Split
  • Outsourced Kinase Profiling Budget Fee-For-Service Provider Split
  • Summary of Survey Findings (1)
  • Number of FTEs Supporting In House Kinase Profiling
  • Cost Per Single Data Point for Kinase Profiling
  • Total Number Kinase Profiling Single Data Points
  • Breakdown of Kinase Profiling Single Data Points
  • Reasons Why Duplicate Point Outsourced Testing (n>1) Preferred:
  • Number of Kinase Primary Screens & Data Points per Screen
  • Primary Screening of Kinase Targets Activities Undertaken
  • Interest & Requirements for Outsourcing Kinase Screening (1)
  • Interest & Requirements for Outsourcing Kinase Screening (2)
  • Size of Kinase Panels Being Used
  • Preferred Size of Kinase Panels Being Offered By Provider
  • Outsourced Offering of Greatest Interest to Respondents
  • Number of Disease-Relevant Kinases Represented in Panels
  • Preferred Number of Disease-Relevant Mutant Kinases Represented in Outsourced Panels
  • Summary of Survey Findings (2)
  • Types of Mode of Action Studies Undertaken on Kinases
  • Use of Different Conditions for Tyrosine Kinase Assays
  • Use of Different Species Variants of Kinases
  • Satisfaction with Data Quality from Current Kinase Assays
  • Interest in Some Outsourced Kinase Profiling & Screening Services
  • Interest in Outsourcing a Panel of Cellular Assays
  • Features of a Kinase Platform of Greatest Interest to Respondents
  • Where Kinase Fee-For-Service Providers Should Prioritize
  • Improvements Required and Unmet Needs in Kinase Panel Profiling and Related Services Today
  • In House Kinase Profiling Reagent Market Estimate
  • Outsourced Kinase Profiling Market Estimate
  • In House Kinase Profiling Reagent Market Segmentation
  • Outsourced Kinase Profiling Market Segmentation
  • Kinase Primary Screening Reagent Market Estimate
  • Kinase Primary Screening Reagent Market Segmentation
  • Summary of Survey Findings (3)
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