Nanostructured Materials for the Biomedical, Pharmaceutical, & Cosmetic Markets

Publication Date	November 2007
Publisher	BCC Research
Product Type	Report
Pages	148
ISBN Number	not applicable
Product Code	BCC00180

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Summary

Nanotechnology has continued to develop rapidly in the 6 years since these three reports were published. In light of these developments, BCC Research decided to take a fresh look at the industry and reevaluate the existing and potential markets for nanoparticulate materials. The present report is an update of the 2001 report on biomedical, pharmaceutical, and cosmetic applications of nanoparticles.

There are a number of other published reports and studies covering various aspects of the market for nanoparticles and nanostructured materials. However, the literature lacks a comprehensive, up-to-date, and realistic technical market assessment that focuses on nanoparticles in biomedical, pharmaceutical, and cosmetic applications.

Since biomedical, pharmaceutical, and cosmetic applications are a major target market for many suppliers of nanoparticles and related technologies, BCC believes that this represents a significant gap in the recent literature. The primary objective of this report is to provide technological background, detailed industry information, and market data and forecasts through 2012, segmented by application and material type.

Scope of study

This report contains:

Descriptions of various types of nanoparticles including nanoparticulate ceramics, metals, alloys, and semiconductors in the form of dry powders, liquid dispersions, coatings and bulk materials
The current market status for nanoparticles, trends and forecasts for growth over the next 5 years
Discussion of organic nanoparticles such as lipids and dendrimers that are expected to play a significant role in future applications
Analysis of nanomaterials-related patents issued during the past 2 years
Profiles of major and minor companies working with nanoparticles.

Report Highlights

The global market for nanoparticles used in biomedical, pharmaceutical and cosmetic applications increased from $170.7 million in 2006 to an estimated $204.6 million in 2007. It should reach $684.4 million by 2012, a compound annual growth rate (CAGR) of 27.3%.
Biomedical applications have the largest share of the market and are expected to account for 75.9% of the market in 2012.
Cosmetic applications are expected to lose market share over the next 5 years and account for just 22.8% of the market in 2012.

Content

Chapter 1 - Executive Summary
- Summary Table: Total World Market Projections For Nanoparticles In Biomedical, Pharmaceutical And Cosmetic Applications, Through 2012 ($ Millions)
- Summary Figure: Total World Market Share Projections For Biomedical, Pharmaceutical And Cosmetic Applications Of Nanoparticles, 2006-2012 (%)
Chapter 2 - Overview
- Terminology
- Products And Properties
  - Catalytic
  - Electrical
  - Magnetic
  - Mechanical
  - Optical And Electronic
- Historical Background
Chapter 3 - Nanoparticle Technologies
- Particle Production
  - Technologies For Producing Inorganic Nanoparticles
    - Gas-Phase Processing
      - Gas Condensation with Thermal Evaporation
      - Vacuum Evaporation on Running Liquids (Verl)
      - Thermal Plasma Synthesis
      - Combustion Synthesis
    - Wet-Chemical Processes
      - Chemical Precipitation
      - Hydrothermal Processing
      - Sol-Gel Processing
    - Solid-State Processes
      - High-Energy Milling
      - Mechanochemical Synthesis
  - Technologies For Producing Organic Nanoparticles
    - Lipids
    - Dendrimers
- Producing Stable Dispersions
- Production Of Coatings, Components, And Devices
  - Coatings
    - Slurry-Coating Routes
      - Dip Coating
      - Spin Coating
      - Comparison with Vapor-Deposition Techniques
    - Electrophoretic Deposition
    - Jet-Printing Process
    - Thermal Spray Coating
    - Direct Production of Nanostructured Coatings and Bulk Solids
      - Electrodeposition
      - Amorphous Crystallization
  - Components And Devices
    - Consolidation of Nanoparticles into Components
      - Three-Dimensional Gel Lamination
      - Dynamic-Magnetic Consolidation
      - Field-Assisted Sintering Techniques
      - Quasi-Isostatic Pressure Process
      - Shockwave Compaction
      - Sinter Forging
      - Severe Plastic Deformation
- Self-Assembly Of Nanoparticles
  - "Bricks-And-Mortar"Approach Orders Gold Particles
  - Micelles Enable Assembly Of Nanolaminates
  - Viral Biotemplate Organizes Nanometal Particles Into Arrays
  - Magnetic Nanoparticle Dispersions Self-Assemble Into Ordered Arrays
- U.S. Patent Analysis
  - Introduction
  - Trends by Country
  - Trends by Assignee
  - Trends by Emphasis: Production versus Application
Chapter 4 - Industry Structure
- Producers
- Commercial Products
- Nanoparticle Pricing
- Commercialization Strategies
- International Competition
- Regulatory Environment
- Regulation In The U.S.
  - U.S. Food and Drug Administration
    - Medical Devices
    - Drugs and Biologicals
    - Combination Products
  - U.S. Environmental Protection Agency
  - Other Agencies
- Regulation Overseas
- Government Funding
  - National Nanotechnology Initiative (Nni)
  - The Advanced Technology Program (Atp)
    - Background
    - Relevant Awards
  - Small Business Innovation Research (Sbir) And Small Business Technology Transfer (Sttr) Programs
    - Background
    - Relevant Awards
Chapter 5 - World Markets
- Introduction
- World Markets Overview
  - Overall Market For Nanoparticles In Biomedical, Pharmaceutical, And Cosmetic Applications
  - Market Segmentation By Application
    - Segmentation in Terms of Value
    - Segmentation in Terms of Volume
  - Market Segmentation By Material Type
    - Segmentation in Terms of Value
    - Segmentation in Terms of Volume
- Detailed Market Analysis
  - Antimicrobial Materials
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
      - Antimicrobial Materials
        
        Nucryst Pharmaceuticals
        
        Surfacine Development Co.
        
        Try Co.
        
        Fraunhofer Institute
      - Mineral Supplements
    - World Markets
      - Antimicrobial Dressings
      - Dietary Supplements
  - Biological Detection And Labeling
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
      - Established Applications
        
        Colloidal Gold
        
        Nanoprobes, Inc.
        
        Orasure Technologies, Inc.
      - Dendrimers
    - Emerging Technologies and Applications
      - BioCrystal, Ltd.
      - Evident Technologies
      - MagnaBioSciences, Llc
      - Microcosm, Inc.
      - Nanocrystal Technologies, Lp
      - Nanosphere, Inc.
      - NymoxPharmaceutical Corp.
      - Quantum Dot Corp.
    - World Markets
      - Colloidal Gold
      - Dendrimers
      - Semiconductor Nanoparticles
      - Superparamagnetic Particles
  - Biomagnetic Separations
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
    - World Markets
  - Drug Delivery
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
      - Cytimmune Sciences
      - PowderMed, Ltd.
      - SkyePharma
      - Starpharma
    - World Markets
  - Magnetic Resonance Imaging (Mri) Contrast Agents
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
    - World Markets
  - Transfection Reagents
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
    - World Markets
  - Antioxidants
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
    - World Markets
  - Orthopedic And Dental Applications
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
    - World Markets
  - Sunscreens And Uv-Protective Cosmetics
    - Background
    - Materials, Production, and Technical Requirements
    - Commercial and Regulatory Status
      - Recent Developments
        
        Process for Preparing Passivated TiO2 Nanoparticles
        
        Titanium Dioxide Coated with Silicon Dioxide
        
        Coated TiO2 Nanoparticles
    - World Markets
Chapter 6 - Company Profiles
- Advanced Nanotechnology, Ltd.
- Amag Pharmaceuticals, Inc.
- Altair Nanotechnologies, Inc.
- Angstrom Medica, Inc.
- Aphios Corp.
- Argonide Corp.
- Bangs Laboratories, Inc.
- Basf Ag
- Berkeley Advanced Biomaterials, Inc.
- Biophan Technologies, Inc.
- Capsulution Nanoscience Ag
- Cytimmune Sciences, Inc.
- Dendritech, Inc.
- Dendritic Nanotechnologies, Inc.
- Dow Chemical Co.
- Dong Seo, Inc.
- Dynal Biotech Asa
- Elementis Specialties
- Emd Chemicals, Inc.
- Evident Technologies
- Evonik Degussa Gmbh
- Flamel Technologies S.A.
- Inframat Corp.
- Invitrogen Corp.
- Ishihara Sangyo Kaisha, Ltd.
- Kemira Specialty
- Magnabiosciences, Llc
- Microcosm, Inc.
- Micromod Partikeltechnologie Gmbh
- Nanocarrier Corp., Ltd.
- Nanophase Technologies Corp.
- Nanoprobes, Inc.
- Nanosphere, Inc.
- Novavax, Inc.
- Nucryst Pharmaceuticals
- Nymox Pharmaceutical Corp.
- Orasure Technologies, Inc.
- Orthovita, Inc.
- Osi Pharmaceuticals, Inc.
- Pharmasol Gmbh
- Polysciences, Inc.
- Powdermed, Ltd.
- Quantum Dot Corp.
- Qiagen N.V.
- Rbc Life Sciences, Inc.
- Sachtleben Chemie Gmbh
- Showa Denko K.K.
- Skyepharma, Plc
- Somalogic, Inc.
- Starpharma Holdings, Ltd.
- Surfacine Development Co.
- Tayca Corp.
List of Tables
- Table 1 Summary Of Property Changes At The Nanocrystalline-Size Scale
- Table 2 Classes Of Inorganic Nanoparticle Production Methods
- Table 3 Particle Production Technologies And Companies Using Them
- Table 4 Comparison Of Coating Technologies
- Table 5 Companies And Institutions Awarded Two Or More Nanomaterial-Related Patents Between October 15, 2005 And October 15, 2007
- Table 6 Companies Worldwide Involved In Nanoparticle Development Or Production For Biomedical And Cosmetic Applications
- Table 7 Factors That Impact The Pricing Of Nanoparticles
- Table 8 Nni Budget Requests For National Institutes Of Health, 2004-2008 ($ Millions)
- Table 9 Advanced Technology Program Awards Related To Biomedical, Pharmaceutical, And Cosmetic Applications Of Nanoparticles, 1999-2008 ($ Millions)
- Table 10 Recipients Of Three Or More Nanomaterials-Related Phase I Sbir/Sttr Awards, 1991-2007 (Numbers Are Lower-Bounds)
- Table 11 World Market Projections For Nanoparticles In Biomedical, Pharmaceutical, And Cosmetic Applications By Type Of Application In Terms Of Value, Through 2012 ($ Millions)
- Table 12 World Market Projections For Nanoparticles In Biomedical, Pharmaceutical, And Cosmetic Applications By Application In Terms Of Volume, Through 2012 (Kg)
- Table 13 World Market Projections For Nanoparticles In Biomedical, Pharmaceutical, And Cosmetic Applications By Material Type In Terms Of Value, Through 2012 ($ Millions)
- Table 14 World Market Projections For Nanoparticles In Biomedical, Pharmaceutical, And Cosmetic Applications By Material Type In Terms Of Volume, Through 2012 (Kg)
- Table 15 Antimicrobial Products Incorporating Silver Nanoparticles
- Table 16 World Market Projections For Nanoparticulate Silver, Through 2012 (Kg/$ Millions)
- Table 17 Basic Requirements Of Diagnostic Tests
- Table 18 Rapid Diagnostic Tests That Use Gold Nanoparticles As Labels
- Table 19 Emerging Nanoparticle-Based Technologies For Biodetection And Labeling By Company
- Table 20 Comparison Of Various Types Of Emerging Nanoparticulate Labeling Technologies
- Table 21 Comparison Between Qdots And Conventional Organic Dyes
- Table 22 World Market Projections For Nanoparticles In Biodetection And Labeling Applications, Through 2012 (Kg/$ Millions)
- Table 23 World Market Projections For Nanoparticulate Gold Used In Biolabeling Applications, Through 2012 (Kg/$ Millions)
- Table 24 World Market Projections For Dendrimers Used In Biolabeling Applications, Through 2012 (Kg/$ Millions)
- Table 25 World Marketprojections For Semiconductor Nanoparticles Used In Biolabeling Applications, Through 2012 (Kg/$ Millions)
- Table 26 World Market Projections For Superparamagnetic Nanoparticles Used In Biolabeling Applications, Through 2012 (Kg/$ Millions)
- Table 27 Producers Of Superparamagnetic Microspheres For Biological Separation Applications
- Table 28 World Markets For Iron Oxide Nanoparticles In Biomagnetic Separations, Through 2012 (Kg/$ Millions)
- Table 29 Criteria For A Nanoparticulate Drug Delivery Vehicle
- Table 30 Companies Active In The Development Of Nanoparticles For Drug-Delivery Applications
- Table 31 Timeline Of New Drug Development Process
- Table 32 World Market Projections For Dendrimer-Based Drug Delivery Systems, Through 2012 (Kg/$ Millions)
- Table 33 Types Of Contrast Agents Used For Mri Imaging
- Table 34 Superparamagnetic Iron Oxide Contrast Media: Regulatory And Marketing Status
- Table 35 World Market Projections For Nanoparticulate Iron Oxide Used In Mri Contrast Media, Through 2012 (Kg/$ Millions)
- Table 36 World Market Projections For Dendrimers Used In Transfecton Reagents, Through 2012
- Table 37 World Market Projections For Silica Hydride Nanoparticles Used In Nutraceuticals, Through 2012 (Kg/$ Millions)
- Table 38 Companies Active In Developing Nanoparticle-Based Bioactive Ceramics
- Table 39WORLD Market Projections For Nanoparticle-Based Synthetic Bone And Tooth Enamels, Through 2012 (Kg/$ Millions)
- Table 40 Sunscreen Inorganic And Organic Active Ingredients
- Table 41 Technical Requirements For Nanoparticles In Uv-Shielding Applications
- Table 42 Producers Of TIO2 And Zno Particles And Dispersions
- Table 43 Sunscreen And Daily-Use Skin Protection Products Containing Nanoparticulate TIO2 And Zno
- Table 44 Projected Trends In Worldwide Sunscreen Sales, Through 2012 ($ Billions)
- Table 45 World Market Projections For TIO2 And Zno Nanoparticles In Sunscreen Applications, Through 2012 (Kg/$ Millions)
List of Figures
- Figure 1 Timeline Of Industry Events, 1920-2000
- Figure 2 Schematic Of The Modified Verl Process To Produce Metal Nanosuspensions
- Figure 3 Sol-Gel Synthesis Flow Chart
- Figure 4 U.S. Patent Trends By Assignee'S Country (Number Of Patents Issued Between 10/15/2005 And 10/15/2007)
- Figure 5 Shares Of U.S. Patents By Assignee (%)
- Figure 6 Shares Of Patents Issued By Emphasis (%)
- Figure 7 Geographical Distribution Of Companies Involved In Nanoparticle Development Or Production For Biomedical And Cosmetic Applications (%)
- Figure 8 Recent Trends In U.S. National Nanotechnology Initiative Spending On Biomedical R&D Nanotechnology Research, Fy 2004-2008 (Budget Requests In $ Millions)
- Figure 9 World Market Projections For Nanoparticles In Biomedical, Pharmaceutical And Cosmetic Applications, 2006-2012 ($ Millions)
- Figure 10 World Market Forecast For Nanoparticles In Biomedical, Pharmaceutical, And Cosmetic Applications, 2006-2012 (Million Kg)
- Figure 11WORLD Nanoparticles Market Share Projections By Application, 2006-2012 (%)
- Figure 12WORLD Market Share Projections For Nanoparticles By Material Type, 2006-2012 (%)
- Figure 13 Projected Trends In The World Market For Nanoparticulate Silver Used In Antimicrobial Applications, 2006-2012 ($ Millions)
- Figure 14 Projected Trends In The World Market For Nanoparticles Used In Biodetection And Labeling Applications, 2006-2012 ($ Millions)
- Figure 15 Projected Trends In The World Market For Nanoparticulate Iron Oxide Used In Bioseparation Applications, 2006-2012 ($ Millions)
- Figure 16 Projected Trends In The World Market For Nanoparticulate Iron Oxide Used In Mri Contrast Applications, 2006-2012 ($ Millions)
- Figure 17 Projected Trends In The World Market For Dendrimers Used In Transfection Reagents, 2006-2012 ($ Millions)
- Figure 18 Projected Trends In The World Market For Silica Hydride Nanoparticles Used In Antioxidant Nutraceutical, 2006-2012 ($ Millions)
- Figure 19 Projected Trends In The World Market For Nanoparticulate Hydroxyapatite, 2006-2012 ($ Millions)
- Figure 20 Projected Trends In The World Market For TIO2 And Zno Nanoparticles Used In Suncreens And Other Skin Care Products, 2006-2012 ($ Millions)