Obesity Drug Discoveries: what the future holds

Publication Date	August 2007
Publisher	Espicom
Product Type	Report
Pages	116
ISBN Number	978-1-85822-294-3
Product Code	ESP00347

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Summary

This chapter of New Drug Futures evaluates, compares and contrasts the prospects for the compounds that will revolutionise the pharmaceutical industry over the next 5 years and beyond in the anti-infective sector. The report includes unique sales forecasts by major product.

The full 400-page report, evaluates, compares and contrasts the prospects for the compounds that will revolutionise the pharmaceutical industry over the next 5 years and beyond. The report covers 8 key therapy areas (alimentary/metabolic, anti-infectives, cancer, cardiovascular, CNS, musculoskeletal, respiratory, vaccines) and includes unique sales forecasts by major product. Click here for more information. This chapter is available separately.

The anti-infectives market is the fifth largest therapeutic category. We estimate that anti-infectives grossed sales of US$28.5 billion in 2005, with a further US$16 billion being derived from hospital-based use and OTC. The majority of prescription-based sales were derived from the US (around 50%) compared to 22% in Europe and Japan. However, growth in Europe at over 5% exceeded that of the US and Japan compared with around 3%.

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Content

Executive summaryWhat is obesity?
Defining obesity
What causes obesity?
What effects does obesity have?
- Figure 1: Effects of obesity on health
- Table 1. Relative risks of health problems associated with obesity
  - The scale of the problem
  - Prevalence of obesity
- Figure 2. Estimated global prevalence of obesity
  - Highest prevalence of obesity
    - Prevalence in the US
    - Prevalence in the UK
    - Prevalence in Europe
    - Prevalence in Asia
    - Prevalence in developing countries
- Figure 3. Percentage of households having both underweight and overweight members in seven countries
- Figure 4. Country comparison - percentage of adults with normal BMI
  - Childhood and future obesity
- Figure 5. Percentage of population that is overweight
- Figure 6. Predicted prevalence of obesity by 2025
  - The economic burden
  - US
  - UK
  - Europe
  - Developing Countries
  - The obesity therapy market
  - Competitor ratio analysis
  - Table 2. Competitor ratio analysis summary
  - Obesity management
  - Controlling energy balance
  - Achieving weight loss
  - Table 3. The benefits of a 10kg weight loss
  - Lifestyle modifications
  - Behaviour therapy
  - Pharmacotherapy
  - Surgery
  - Approved drugs for obesity management
- Table 4. History of drug treatments for obesity
- Table 5. Anti-obesity drugs approved for short-term use
- Table 6. Anti-obesity drugs approved for long-term use
  - Acomplia
  - Approval History
  - Key Markets
  - Key Agreements
  - Clinical Trial Data
  - Safety Issues
  - Further Development
  - Sales
  - Sales Forecast
- Figure 7. Acomplia reported and projected sales, 2006A-2012E (EUR million)
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - Meridia/Reductil
  - Approval History
  - Key Markets
  - Key Agreements
  - Clinical Trial Data
- Table 7. Percentage change in subject's body weight at varying doses of sibutramine
- Table 8. Health profile of subjects losing at least 5 per cent of body weight
  - Safety Issues
  - Further Development
  - Xenical/alli
  - Approval History
  - Key Markets
  - Key Agreements
  - Patent History
  - Clinical Trial Data
  - Safety Issues
  - Further Development
  - Sales
  - Sales Forecast
- Figure 8. Reported and projected sales of Xenical 2001A-2011E
  - Regulatory authority guidelines for drug approval
  - Approval for additional indications
  - Potential new drugs
- Table 9. Novel drugs in development by Phase
- Table 10. Novel drugs in development by company
  - Drugs in clinical development
- Figure 9. Estimated launch dates for profiled drugs
  - Beta3 adrenergic receptor modulators
  - Table 11. Beta3 adrenergic receptor modulators in development
  - KR P-204 (N-5984)
  - Safety Issues
  - Competitors
  - Launch Prediction
  - Cannabinoid receptor modulators
- Table 12. Cannabinoid receptor modulators in development:
  - CP-945,598
  - Safety Issues
  - Competitors
  - Launch Prediction
  - taranabant
  - Safety Issues
  - Competitors
  - Launch Prediction
  - AVE 1625
  - Safety Issues
  - Competitors
  - Launch Prediction
  - SLV 319
  - Key Agreements
  - Safety Issues
  - Competitors
  - Launch Prediction
  - Digestive inhibitors/lipid metabolism modulators
- Table 13. Digestive inhibitors/lipid metabolism modulators in development cetilistat
  - Key Agreements
  - Clinical Trial Data
  - Safety Issues
  - Further Developments
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - 869682
  - Safety Issues
  - Competitors
  - Launch Prediction
  - Histaminergic system modulators
- Table 14. Histaminergic system modulators in development
  - OBE 101
- Table 15. Properties of OBE101 and histamine compared
  - Key Agreements
  - Clinical Trial Data
  - Safety Issues
- Table 16. Adverse effects of OBE101 when compared to anti-obesity medications currently in use
  - Patent History
  - Further Development
  - Competitors
  - Launch Prediction
  - Hormone analogues
- Table 17. Hormone analogues in development pramlintide
  - Clinical Trial Data
  - Further Development
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - liraglutide
  - Clinical Trial Data
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - obinepitide
  - Patent History
  - Clinical Trial Data
  - Further Development
  - Safety Issues
  - Competitors
  - Launch Prediction
  - PYY 3-36
  - Key Agreements
  - Patent History
  - Clinical Trial Data
  - Further Development
  - Safety Issues
  - Competitors
  - Launch Prediction
  - Monoamine reuptake inhibitors/5-HT receptor modulators
- Table 18. Monoamine reuptake inhibitors/5-HT receptor modulators in developmentlorcaserin
  - Patent History
  - Clinical Trial Data
- Table 19. Incidence of FDA-defined valvulopathy
  - Further Development
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - tesofensine
  - Clinical Trial Data
  - Further Development
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Risks associated with drug development in therapeutic class
  - Neuropeptide receptor modulators
- Table 20. Neuropeptide receptor modulators in development S-2367
  - Clinical Trial Data
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - Combination drugs
- Table 21. Combination drugs in development
  - Contrave
  - Patent History
  - Clinical Trial Data
  - Further Developments
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - Qnexa
  - Clinical Trial Data
  - Further Development
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - pramlintide+phentermine/sibutramine
  - Safety Issues
  - Competitors
  - Launch Prediction
  - Empatic
  - Patent History
  - Clinical Trial Data
- Table 22. Percentage change in body weight at week 24
  - Safety Issues
  - Launch Prediction
  - Competitor Ratio Analysis
  - Novelty/rationale for mechanism of action
  - Proof of concept/clinical data
  - Management/clinical expertise
  - Competition within the marketplace
  - Risks associated with drug development in therapeutic class
  - Recently-terminated p rogrammes
  - AMG 076
  - AOD 9604
  - Clinical Trial Data
  - CP-741952
  - CYT 009-GhrQb
  - Clinical Trial Data
  - oleoyl-estrone
  - Patent History
  - Clinical Trial Data
  - Further Development
  - PF-431499
  - The f uture of obesity treatment
  - Towards an all-encompassing cure; targeting the metabolic syndrome?
  - Recent advances and future developments
  - CD 36
  - Targeting ghrelin
  - Vaccines
  - Gene therapy
  - RNA interference
  - Conclusions
  - Sources
  - Espicom sources
  - Others