All Change in the Advanced Wound Care Market 2009

Publication Date	May 2009
Publisher	Espicom
Product Type	Report
Pages	236
ISBN Number	978-1-85822-350-6
Product Code	ESP00204

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Summary

The rapid progress of the NPWT sector and the exit of Johnson & Johnson and Bristol-Myers Squibb has changed this sector fundamentally. This report examines the market, product ranges and growth drivers, and provides market share data by company for major product sectors and growth forecasts to 2013. Also included are competitor reviews of 115 leading and developing companies.

The Rapid Progress Of The Npwt Sector And The Exit Of Johnson & Johnson And Bristol-Myers Squibb Has Changed This Sector Fundamentally. Who Are The Players And Technologies That Are Benefiting From These Developments?

Key Areas Addressed:

Growth forecasts to 2013 for the major moist wound care, NPWT and biological wound care sectors and regions
Market share data by company for major product sectors
An examination of market and product growth drivers
Extensive review of product ranges within each wound care sector

Competitor reviews of 115 leading and developing companies

While the advanced wound care market has generally seen double-digit growth over the past five years, the growth rate slowed in 2008 and this trend is expected to continue in 2009 with a global valuation of US$4.9 billion in 2008.

The number of patients requiring treatments for chronic and challenging wounds has and will continue to rise. However, growth in terms of sales volumes is being affected by the higher number of companies entering this market, which is increasing competition and bringing down selling prices. In addition, the market is likely to see pressures on reimbursement levels as governments seek to rein in healthcare expenditure during the current economic downturn.

While several leading companies have added to their advanced wound care portfolios, two leading healthcare companies have exited this market: Johnson & Johnson (via Ethicon) and Bristol-Myers Squibb (via ConvaTec). For both companies, advanced wound care was not a key part of their overall operations and the move may have been timely, as market growth is slowing in their sector of interest and neither company had a presence in the rapidly-growing field of NPWT.

Focus on the key issues and trends

Private equity adds a new dimension to the market

Other manufacturers did not benefit from the decision of J&J and BMS to exit the market; both ConvaTec and the Johnson & Johnson Professional Wound Care business were purchased by private equity firms.

The Johnson & Johnson Professional Wound Care business became Systagenix Wound Management in December 2008 following One Equity Partners' acquisition of the business. ConvaTec became a separate entity from Bristol-Myers Squibb in August 2008 following its sale to new owners, Nordic Capital and Avista Capital Partners, in a deal valued at US$4.1 billion. A month after the transition, in September 2008, ConvaTec acquired Unomedical, a Danish manufacturer of hospital products and infusion devices, from Nordic Capital Fund IV. The combined company, which retains the ConvaTec name, has approximately 8,000 employees and annual revenue in the region of US$1.6 billion.

Negative Pressure Wound technology continues to take market share as companies position themselves for growth
Expected to exceed US$2 billion by 2013, NPWT technology is continuing to gain ground and is taking market share from moist wound care products. Many of the leaders in other areas of advanced wound care have seen their market share decline.

This is expected to continue as NPWT is expanded into currently under-penetrated geographic regions and for use in new indications and healthcare environments. In response, several of the traditional wound care market leaders have entered or plan to enter the NPWT market. Notably, Smith & Nephew (S&N) acquired BlueSky Medical in 2007, Getinge launched a NPWT system in 2008 following its acquisition of Huntleigh Technology and Mlnlycke is also looking into this area. In addition, ConvaTec has recently gained a presence in the NPWT market through an exclusive global agreement for Boehringer Technologies' Engenex NPWT system.

While there is clearly increased competition for NPWT, there are certain barriers to developing a presence in this market. The market model involves the rental of NPWT devices to healthcare providers and the sale of disposables. This model requires companies to have the capabilities to deliver and collect the rental products, either themselves or through partners, which could be a major hindrance to companies wanting to enter the NPWT market.

Regional Sales: A tale of two technologies

The advanced wound care market is currently dominated by the European region, which accounted for 41% of the total sales volumes in the market in 2008. In addition, the US represented 39% of the market and the rest of the world 20.5%. However, the adoption of different types of advanced wound care technologies differs between these regions, with Europe and the rest of the world more broadly adopting moist wound care dressings and the US being the largest market for NPWT. Currently, Espicom estimates that around 70% of the NPWT market is in the US and only 30% is in the international market, providing continued growth potential for NPWT outside the US. However, for moist wound care, over 50% of the market is in Europe and only around 25% in the US.

About the author

This report has been written by Joanne Tibballs, an experienced Espicom researcher and former editor of Medical Device Companies Analysis. In addition to this report she has written Medical IT: Understanding the major players and products and The Executive Guide to Molecular Imaging.
Just some of the 115 companies profiled

THE MARKET LEADERS

3M
Coloplast
ConvaTec
Covidien
Hartmann Group
Kinetic Concepts
Medline Industries
Mlnlycke Health Care
Smith & Nephew
Systagenix Wound Management

OTHER COMPANIES INCLUDE

ACell
Advitech
Agennix
AGT Sciences
Archimed
Argentum Medical
Aspen Surgical Products
Avita Medical
B. Braun
BioElectronics
Biotec Pharmacon
Boehringer Laboratories
Care-Tech Laboratories
Celleration
Collagen Matrix
Comvita
Cytomedix
DermaRite Industries
DeRoyal
Dr Suwelack Skin & Health Care
Ferris
FibroGen
Fidia Advanced Biopolymers
First Water
Forticell Bioscience
Genadyne Biotechnologies
Genzyme Biosurgery
Getinge
Healthpoint
HemCon Medical Technologies
Hollister Wound Care
Hydrofera
Innocoll and CollMED Laboratories
Innovative Therapies
Integra LifeSciences Holdings
Intercytex
Ivivi Technologies
IYIA Technologies
Kalypto Medical
Kikgel
Medestea Internazionale
MediWound
Nucryst Pharmaceuticals
Oculus Innovative Sciences
Organogenesis
Oxygen Biotherapeutics
Pegasus Biologics
Polyheal
Premco Medical Systems
Quick-Med Technologies
RegeneRx Biopharmaceuticals
Regenesis Biomedical
SanoMed Manufacturing
SANUWAVE
Sring
Southwest Technologies
TGR BioSciences
Tissue Genesis
Tissue Regeneration Technologies
ULURU
URGO
Vibrant Medical
Vomaris
York Pharma
ZooBiotic

Content

EXECUTIVE SUMMARY
OVERVIEW
- Wound Care Products
- Advanced Wound Care Products
- Fig.1: Percentage of the Professional Wound Care Market by Product, 2008
- Complex Wounds: The Role of Advanced Wound Care
- Diabetic Ulcers
- Pressure Ulcers
- Venous Stasis Ulcers
ADVANCED WOUND CARE MARKET COMPETITORS
- Select Manufacturers' Wound Care Sales, 2003-2008 (US$ million)
- Companies' Wound Care Sales Growth, 2007-2008 (US$ million unless stated)
- Fig.2: Advanced Wound Care Market Shares, 2008
ADVANCED WOUND CARE MARKET DYNAMICS
- Professional Wound Care Market by Product, 2007-2013 (US$ million)
- Global Wound Care Market Growth by Product, 2008-2013 (%)
- Regional Perspective
- Advanced Wound Care Market by Region, 2007-2013 (US$ million)
- Advanced Wound Care Market Growth by Region, 2007-2013 (%)
- Fig.3: Advanced Wound Care Market by Region, 2008
- Changing Industry Landscape
- Advanced Wound Care Acquisitions, 2007-2009
ADVANCED WOUND CARE PRODUCTS & TECHNOLOGIES
- Fig.4: Advanced Wound Care Market by Product Type, 2008
- Fig.5: Advanced Wound Care Market by Product Type, 2013
DEVICE-BASED WOUND CARE
- Negative Pressure Wound Therapy
- Fig.6: NPWT Market, 2006-2013 (US$ million)
- Kinetic Concepts' V.A.C. Therapy
- ABThera Open Abdomen NPWT System
- V.A.C. Clinical Studies
- Future Developments and Market Expansion
- Smith & Nephew NPWT Systems
- Boehringer Technologies' Engenex NPWT System
- Genadyne Biotechnologies' A4 NPWT System
- Getinge's WoundASSIST TNP System
- Innovative Therapeutics' Svedman and Sved Systems
- Kalypto Medical's NPD 1000 System
- Medela's Invia NPWT Systems
- Premco Medical Systems' Prodigy NPWT Systems
- Prospera's PRO NPWT Systems
- Talley Group's Venturi Systems
- Electrical Stimulation
- Biofisica's POSiFECT Bio-Electric Stimulation Therapy
- Ivivi Technologies' Targeted Pulsed Electromagnetic Field Therapy
- Synapse Microcurrent
- Vomaris' PROCELLERA
- Ultrasound
- Arobella Medical's Qoustic Wound Therapy System
- All Change in the Advanced Wound Care Market 2009
- Celleration's MIST Therapy System
- HeaLFUS' CaviClean
- Misonix' SonicOne Ultrasonic Wound Debridement System
- NanoVibronix' PainShield
- Sring's Sonoca Systems
- Extracorporeal Shock Wave Therapy
SANUWAVE's dermaPACE
- Tissue Regeneration Technologies' DermaGold
- Regenesis Biomedical's Provant Wound Therapy System
- SanoMed's Photizo Light Therapy
- Vibrant Medical Vibration Therapy
MOIST WOUND CARE PRODUCTS
- Fig.7: Moist Wound Care Market, 2007-2013 (US$ million)
- Moist Wound Care Market, 2007-2013 (US$ million)
- Moist Wound Care Market Growth, 2008-2013 (%)
- Hydrogels
- Key Hydrogel Products and Manufacturers
- New Hydrogel Technologies
- AGT Sciences' Hydrogel Technology
- BioCure's GelSpray
- First Water's Pro-ionic Gel Dressings
- Nanotherapeutics NanoDOX 1% Doxycycline Monohydrate Hydrogel
- Oculus Innovative Sciences' Microcyn Hydrogel
- ULURU's Nanoflex Technology
- Hydrocolloid Dressings
- Key Hydrocolloid Products and Manufacturers
- New Hydrocolloid Technologies
- First Water's Pro-ionic Hydrocolloid Dressings
- Alginates
- Key Alginate Products and Manufacturers
- Foam Dressings
- Key Foam Products and Manufacturers
- New Foam Technologies
- Coloplast's Biatain
- ConvaTec's Versiva XC Gelling Foam Dressings
- First Water's Pro-ionic Foam Dressings
- Smith & Nephew's Allevyn Dressings
- Composite Dressings
- Key Composite Products and Manufacturers
- M Tegaderm Matrix Dressing with PHI technology
- Archimed's Oxyzyme
- ConvaTec's AQUACEL Hydrofiber Dressings
- Derma Sciences' XTRASORB Super Absorbent Dressing
- First Water's Pro-ionic Matrix
- Activated Charcoal Dressings
- Key Charcoal Products and Manufacturers
- Transparent Film Dressings
- Key Transparent Film Products and Manufacturers
- New Transparent Film Technologies
- First Water's Pro-ionic Film
- Antimicrobial Dressings
- All Change in the Advanced Wound Care Market 2009
- Fig.8: Antimicrobial Dressings Market, 2007-2013 (US$ million)
- Silver Dressings
- Key Silver Products and Manufacturers
- Argentum Medical's Silverlon
- AcryMed's SilvaSorb
- ConvaTec's AQUACEL Ag
- Medline's Silver Antimicrobial Dressings
- Smith & Nephew's Acticoat Dressings
- Smith & Nephew's Algisite Ag, Allevyn Ag and Biostep Ag
- Systagenix Wound Management's Silvercel and Actisorb Silver 220
- URGO's UrgoCell Silver
- New Silver Technologies
- Honey Dressings
- Advancis Medical's Activon
- Comvita's Medihoney
- Sanoskin's SanoSkin-Melladerm
- Triticum's L-Mesitran Range
- Other Antimicrobial Dressings
- Iodine-based Dressings
- PHMB Antimicrobial Dressings
- M's Tegaderm CHG
- Derma Sciences' Dermagran
- Healthpoint Hydrofera Blue
- Innocoll's CollaRx Gentamicin
- Oculus Innovative Sciences' Microcyn Technology
- Quick-Med Technologies' NIMBUS
BIOLOGICS AND PHARMACEUTICALS
- Fig.9: Wound Care Biologics Market, 2007-2013 (US$ million)
- Collagen-Based Wound Care Products
- Argentum Medical's BIOPAD
- BioCore Medical Technologies' Kollagen
- Collagen Matrix' Matrix Collagen Dressing
- Covalon Technologies' Biostep and ColActive
- Dr Suwelack Skin & Health Care's Puracol Plus
- Eucare Pharmaceuticals
- Innocoll's CollaRx Technology
- Lescarden's Catrix Wound Dressing
- Pegasus Biologics' Unite Biomatrix
- Systagenix Wound Management's Collagen-Based Dressings
- Wound Management Technologies' CellerateRx
- Products in Development
- Covalon Technologies
- Dr Suwelack Skin & Health Care's SHC-Matrix
- Innocoll's Collieva Ag, DermaSIL and CollaRx Lidocaine Sponge
- FibroGen's Synthetic Collagen
- Skin Substitutes
- ACell/Medline's MatriStem Extracellular Matrix Wound Sheet
- Advanced BioHealing's Dermagraft
- Avita Medical's ReCell
- Cook Biotech's Oasis Wound Matrix
- Dr Suwelack Skin & Health Care's Matriderm
- All Change in the Advanced Wound Care Market 2009
- Fidia Advanced Biopolymers' HYAFF
- Genzyme's Epicel Cultured Epidermal Autografts
- Integra LifeSciences' Collagen-Glycosaminoglycan Matrix
- LifeCell's AlloDerm
- Medestea Internazionale's Veloderm
- Mlnlycke's Xelma
- Organogenesis' Apligraf
- Promethean LifeSciences' GammaGraft
- Tissue Genesis' Cell Isolation System
- UDL Laboratories/S&N's Biobrane
- LifeCell/Wright Medical Group's Graftjacket and Osteoset
- York Pharma's MySkin and CryoSkin
- Products in Development
- Forticell Bioscience's OrCel
- Intercytex' ICX-SKN
- Organogenesis
- US Armed Forces Institute of Regenerative Medicine
- York Pharma's Lyphoderm
- Growth Factors
- Recombinant Growth Factors
- Products in Development
- Plasma-Derived Growth Factors
- Cytomedix' AutoloGel System
- SafeBlood Technologies' Autologous Platelet Grafting System
- Enzymatic Debriding Agents
- Healthpoint's Collagenase Santyl Ointment
- Products in Development
- Maggot Enzyme-based Dressing Project
- Mediwound's Debrase Gel Dressing
- Novel Biologic and Pharmaceutical Products in Development
- Agennix' Talactoferrin
- Biotec Pharmacon's SBG Compound
- Brennen Medical's Oat Beta-Glucan
- Covalon Technologies' EPAS-1 Project
- Derma Sciences' DSC127
- HealOr's Protein Kinase C-Based Therapeutics
- ImmuneRegen BioSciences' Homspera
- Polyheal's Microsphere-Based Technology
- RegeneRx' RGN-137
- RGN-137 for Pressure Ulcers
- RGN-137 for Venous Stasis Ulcers
- RGN-137 for Epidermolysis Bullosa (EB)
- TGR BioSciences' Tissue Regeneration Technologies
OTHER PRODUCTS
- Oxygen Dressings
- AcryMed's Oxygenated Dressing
- Archimed's Oxyzyme
- Oxygen Biotherapeutics' Oxybiocyte
- Sangui BioTech's HEMO2
- SPRAY
- Chitosan Dressings
- BioSyntech's BST-DermOn
- All Change in the Advanced Wound Care Market 2009
- HemCon Medical Technologies
- Sangui BioTech's Chitoskin
MANUFACTURERS
THE MARKET LEADERS
- Recent Key Events
- Current Alliances
- Becton Dickinson
- Kinetic Concepts
- Greystone Pharmaceuticals
- Financial Performance
- M Health Care - Operating Results, 2005-2008 (US$ million)
- Fig.10:
- M Health Care - Revenue by Business Unit, 2008
- Fig.11:
- M Health Care - Revenue by Region, 2008
- Latest Results and Outlook
- Coloplast
- Current Alliances
- Smith & Nephew
- Johnson & Johnson
- Financial Performance
- Coloplast - Operating Results, 2004-2008 (DKr million)
- Revenue by Product Line, 2007-2008 (DKr million)
- Fig.12: Coloplast: Percentage of Revenue by Product Line, 2008
- Fig.13: Coloplast - Wound & Skin Care Revenue, 2003-2008 (DKr million)
- Latest Results
- Outlook
- ConvaTec
- Recent Key Events
- Current Alliances
- Boehringer Technologies
- HemCon Medical Technologies
- Financial Performance
- ConvaTec - Operating Results, 2006-2008 (US$ million)
- ConavTec - Revenue by Product Line, 2002-2007 (US$ million)
- ConvaTec Wound Therapeutics Sales by Region, 2003-2007 (US$ million)
- Unomedical's Results
- Unomedical - Operating Results, 2003-2007 (DKr million)
- Covidien
- Financial Performance
- Covidien - Operating Results, 2004-2008 (US$ million)
- Fig.14: Covidien - Revenue by Division, 2008
- Hartmann Group
- Current Alliances
- Indian Apollo Hospital Group and the West China Hospital
- Kinetic Concepts
- Financial Performance
- Hartmann - Operating Results, 2004-2008 (EUR million)
- Hartmann Wound Management Results, 2007-2008 (EUR million)
- Fig.15: Hartmann - Revenue by Division, 2008
- Latest Results and Outlook
- Kinetic Concepts
- All Change in the Advanced Wound Care Market 2009
- Recent Key Events
- Current Alliances
- M
- Avail Medical Products
- NovaBay Pharmaceuticals
- Hartmann
- Wake Forest University
- GPO Contracts and US Customers
- Litigation
- Smith & Nephew
- Medela
- Innovative Therapies
- Mlnlycke Health Care
- Boehringer Technologies and ConvaTec
- Financial Performance
- KCI - Operating Results, 2004-2008 (US$ million)
- KCI - Revenue by Product Type, 2004-2008 (US$ million)
- KCI - V.A.C. Revenue, 2004-2008 (US$ million)
- KCI - V.A.C. Revenue by Region, 2006-2008 (US$ million)
- Fig.16: KCI- Percentage of V.A.C. Revenue by Region, 2008
- Fig.17: KCI- Percentage of V.A.C. Revenue by Type, 2008
- Latest Results
- Outlook
- Medline Industries
- Current Alliances
- ACell
- Avery Dennison Medical
- AcryMed
- Lohmann & Rauscher
- Dr Suwelack Skin & Health Care
- GPO Contracts
- Mlnlycke Health Care
- Current Alliances
- University of Nottingham and AGT Sciences
- Litigation
- Kinetic Concepts
- Financial Performance
- Mlnlycke - Operating Results, 2006-2008 (EUR million)
- Smith & Nephew
- Recent Key Events
- Current Alliances
- Coloplast
- Apria Healthcare Group
- Universal Hospital Services
- Covalon Technologies
- UDL Laboratories
- Movianto Deutschland
- Lescarden/Valeant Pharmaceuticals
- Derma Sciences
- Nucryst Pharmaceuticals
- Litigation with Kinetic Concepts
- All Change in the Advanced Wound Care Market 2009
- Financial Performance
- S&N - Operating Results, 2004-2007 (US$ million)
- S&N Advanced Wound Care Results, 2004-2008 (US$ million)
- Fig.18: S&N Advanced Wound Care Sales by Region, 2008
- Latest Results
- Systagenix Wound Management
- Other Companies
- ACell
- AcryMed
- Financial Performance
- I-Flow Operating Results by Segment, 2008 (US$ thousand)
- Fig.19: I-Flow - Revenue by Segment, 2008
- Advanced BioHealing
- Advanced Medical Solutions
- Current Agreements
- Systagenix
- B. Braun
- Financial Performance
- AMS Advanced Wound Care Division - Operating Results, 2005-2008 ( thousand)
- Fig.20: AMS - Revenue by Division, 2008