MediPoint: Cardiac Rhythm Management - Current and Future Players

MediPoint: Cardiac Rhythm Management - Current and Future Players

MediPoint: Cardiac Rhythm Management - Current and Future Players

Summary

Cardiac rhythm management (CRM) comprises any method of treatment aimed at regulating the heart’s rhythm, including medication, medical devices, and occasionally surgery. There can be a number of reasons why CRM is needed, all of which generally involve malfunctions of the heart’s electrical system, and are related to cardiac dyssynchrony. While medication can be effective in mild to moderate cases, patients with more severe conditions must turn to device use or surgical intervention in order to receive the therapy they require. Over the years, CRM device treatment has become less invasive, and significant advances in pacing and pulse generator technology have enabled effective long-term device therapy with limited complications.

The report identifies and analyzes the key companies shaping and driving the global CRM market. The report provides insight into the competitive CRM landscape, including new companies entering the market and pipeline products in development. This report is built using data and information sourced from proprietary databases, secondary sources and primary research interviews and survey with leading cardiologists, with in-house analysis conducted by GlobalData’s team of industry experts.

Scope

- Investigation of current and future market competition for CRM
- Competitor assessment including device approval analysis.
- Coverage of key market players and company profiles including business description, financial overview and SWOT analysis.
- Strategic assessment of the device sector through market impact analysis, future market scenario and company analysis.
- Direct quotes from Key Opinion Leaders (KOL) as well as cardiologists using CRM devices in clinical practice.

Reasons to buy

- Gain a high level view of the trends shaping and driving the CRM market for coronary applications and peripheral applications in the lower extremity.
- Assess competitiveness of products in market by understanding the strengths and weaknesses of current competition.
- Drive revenues, formulate effective sales and marketing strategies and gain in-depth understanding of the competitive landscape
- Take a comprehensive look at the market’s device pipeline and identify promising, paradigm-shifting products.
- Create an effective counter-strategy to gain a competitive advantage against those currently in the market
Table of Contents

1 Table of Contents 2
1.1 List of Tables 6
1.2 List of Figures 10
2 Introduction 11
2.1 Catalyst 11
3 Competitive Assessment 13
3.1 Overview 13
3.2 Global Market Share 13
3.2.1 Pacemaker and CRT-P Market Company Share Globally 13
3.2.2 ICD and CRT-D Market Company Share Globally 15
3.3 Regional Market Share 16
3.3.1 Pacemaker and CRT-P Market Company Share in the US 16
3.3.2 ICD and CRT-D Market Company Share in the US 17
3.3.3 Pacemaker and CRT-P Company Share in Europe 18
3.3.4 ICD and CRT-D Market Company Share in Europe 19
3.3.5 Pacemaker and CRT-P Market Company Share in Emerging Markets 20
3.3.6 ICD and CRT-D Market Company Share in Emerging Markets 21
3.3.7 Pacemaker and CRT-P Market Company Share in Japan 22
3.3.8 ICD and CRT-D Market Company Share in Japan 23
4 Pipeline Products 24
4.1 Overview 24
4.2 Pipeline Products by Phase in Development 24
4.3 Pacemaker and CRT-P Product Profiles 25
4.3.1 Aortic Pacemaker (Hadasit Medical Research Services & Development Ltd.) 25
4.3.2 Cardiac Energy Harvesting Pacemaker (University of Michigan) 26
4.3.3 Endurance Microgenerator (Endurance Rhythm) 26
4.3.4 Implantable Dual-Chamber Pacemaker (MicroPort Scientific) 27
4.3.5 Unconditional MRI-Compatible Implantable Pacemaker (Kenergy, Inc.) 27
4.3.6 Tissue-Engineered Autonomous Pacemaker (Duke University) 28
4.3.7 Wireless Cardiac Stimulation Device (EBR Systems, Inc.) 28
4.4 ICD and CRT-D Product Profiles 29
4.4.1 Atrial Defibrillator (SmartWave Medical Ltd.) 29
4.4.2 CardiaLen (CardiaLen, Inc.) 29
4.4.3 Chronicle (Medtronic) 30
4.5 Clinical Trials to Watch 31
4.5.1 Overview 31
4.5.2 SELECT-LV Trial of WiCS-LV System (EBR Systems, Inc.) 31
4.5.3 MultiPoint Pacing Clinical Trial of Quadra Assura CRT-D (Medtronic) 33
4.5.4 MADIT-ASIA Trial with Invive CRT-P (Boston Scientific) 34
4.5.5 MultiPoint Pacing IDE Study of Promote Quadra (St. Jude Medical) 36
4.5.6 Post Approval Study of S-ICD System (Boston Scientific) 37
4.5.7 ProMRI Study of the Evia/Entovis Pacemaker System 39
4.5.8 MIRACLE EF Clinical Study of Consulta CRT-P (Medtronic) 41
5 Current and Future Players 44
5.1 Overview 44
5.2 Trends in Corporate Strategy 44
5.3 Biotronik 45
5.3.1 Overview 45
5.3.2 Portfolio Evaluation 47
5.3.3 Commercial Positioning 57
5.3.4 Company SWOT Analysis 58
5.4 Boston Scientific 58
5.4.1 Overview 58
5.4.2 Portfolio Evaluation 60
5.4.3 Commercial Positioning 69
5.4.4 Company SWOT Analysis 70
5.5 Impulse Dynamics 70
5.5.1 Overview 70
5.5.2 Portfolio Evaluation 70
5.5.3 Commercial Positioning 71
5.5.4 Company SWOT Analysis 71
5.6 Medtronic 72
5.6.1 Overview 72
5.6.2 Portfolio Evaluation 74
5.6.3 Marketed Products 76
5.6.4 Additional Products 84
5.6.5 Commercial Positioning 86
5.6.6 Company SWOT Analysis 88
5.7 Sorin Group 88
5.7.1 Overview 88
5.7.2 Portfolio Evaluation 90
5.7.3 Marketed Products 91
5.7.4 Commercial Positioning 92
5.7.5 Company SWOT Analysis 93
5.8 St. Jude Medical 93
5.8.1 Overview 93
5.8.2 Portfolio Evaluation 94
5.8.3 Marketed Products 96
5.8.4 Commercial Positioning 109
5.8.5 Company SWOT Analysis 110
6 Appendix 111
6.1 Bibliography 111
6.2 Abbreviations 124
6.3 Report Methodology 129
6.3.1 Overview 129
6.3.2 Coverage 129
6.3.3 Secondary Research 129
6.3.4 Forecasting Methodology 130
6.3.5 Primary Research - Key Opinion Leader Interviews 131
6.3.6 Expert Panel Validation 132
6.4 Physicians and Specialists Included in this Study 132
6.5 About the Authors 134
6.5.1 Analysts 134
6.5.2 Global Head of Healthcare 135
6.6 About MediPoint 136
6.7 About GlobalData 136
6.8 Disclaimer 136



List of Tables

Table 1: Pacemaker and CRT-P Market, Global, Company Share (%), 2012 14
Table 2: ICD and CRT-D Market, Global, Company Share (%), 2012 15
Table 3: Pacemaker and CRT-P Market, US, Revenue ($) and Company Share (%), 2012 16
Table 4: ICD and CRT-D Market, US, Revenue ($) and Company Share (%), 2012 17
Table 5: Pacemaker and CRT-P Market, Europe, Revenue ($) and Company Share (%), 2012 18
Table 6: ICD and CRT-D Market, Europe, Revenue ($) and Company Share (%), 2012 19
Table 7: Pacemaker and CRT-P Market, Emerging Markets, Revenue ($) and Company Share (%), 2012 20
Table 8: ICD and CRT-D Market, Emerging Markets, Revenue ($) and Company Share (%), 2012 21
Table 9: Pacemaker and CRT-P Market, Japan, Revenue ($) and Company Share (%), 2012 22
Table 10: ICD and CRT-D Market, Japan, Revenue ($) and Company Share (%), 2012 23
Table 11: Product Profile - Aortic Pacemaker 25
Table 12: Product Profile - Cardiac Energy Harvesting Pacemaker 26
Table 13: Product Profile - Endurance Microgenerator 26
Table 14: Product Profile - MicroPort Pacemaker 27
Table 15: Product Profile - Kenergy Pacemaker 27
Table 16: Product Profile - Tissue-Engineered Autonomous Pacemaker 28
Table 17: Product Profile - Wireless Cardiac Stimulation Device 28
Table 18: Product Profile - Atrial Defibrillator 29
Table 19: Product Profile - CardiaLen 29
Table 20: Product Profile - Chronicle 30
Table 21: Clinical Trial for WiCS-LV System 31
Table 22: Clinical Trial for Quadra Assura CRT-D 33
Table 23: Clinical Trial for Invive CRT-P 34
Table 24: MultiPoint Pacing IDE Study for Promote Quadra 36
Table 25: Post Approval Study of S-ICD System 37
Table 26: ProMRI Study of the Evia/Entovis Pacemaker System 39
Table 27: MIRACLE EF Clinical Study of Consulta CRT-P 41
Table 28: Company Profile - Biotronik 47
Table 29: Product Profile - Cylos 990 50
Table 30: Product Profile - Effecta 51
Table 31: Product Profile - Evia/Entovis 52
Table 32: Product Profile - Estella 53
Table 33: Product Profile - Stratos 54
Table 34: Product Profile - Ilesto 7 54
Table 35: Product Profile - Lumax 57
Table 36: Biotronik SWOT Analysis, 2012 58
Table 37: Company Profile - Boston Scientific 59
Table 38: Product Profile - Advantio 62
Table 39: Product Profile - Altrua 63
Table 40: Product Profile - Cognis 64
Table 41: Product Profile - Energen 65
Table 42: Product Profile - Incepta 65
Table 43: Product Profile - Ingenio 66
Table 44: Product Profile - Invive 67
Table 45: Product Profile - Punctua 68
Table 46: Product Profile - S-ICD System 2.0 68
Table 47: Product Profile - Teligen 69
Table 48: Boston Scientific SWOT Analysis, 2012 70
Table 49: Company Profile - Impulse Dynamics 70
Table 50: Product Profile - Optimizer IVs 71
Table 51: Impulse Dynamics SWOT Analysis, 2012 71
Table 52: Company Profile - Medtronic 73
Table 53: Product Profile - Advisa 76
Table 54: Product Profile - Adapta 77
Table 55: Product Profile - Brava/Viva 78
Table 56: Product Profile - Consulta 79
Table 57: Product Profile - EnPulse 79
Table 58: Product Profile - EnRhythm 80
Table 59: Product Profile - Ensura MRI 80
Table 60: Product Profile - Evera 81
Table 61: Product Profile - Protecta 81
Table 62: Product Profile - Secura 82
Table 63: Product Profile - Syncra 83
Table 64: Product Profile - Revo 83
Table 65: Product Profile - Concerto 84
Table 66: Product Profile - EnTrust 85
Table 67: Product Profile - Maximo II 85
Table 68: Medtronic SWOT Analysis, 2012 88
Table 69: Company Profile - Sorin Group 90
Table 70: Product Profile - Esprit 91
Table 71: Product Profile - Paradym 91
Table 72: Product Profile - Reply 2000 92
Table 73: Sorin Group SWOT Analysis, 2012 93
Table 74: Company Profile - St. Jude Medical 94
Table 75: Product Profile - Accent 97
Table 76: Product Profile - Accent MRI 98
Table 77: Product Profile - Anthem 99
Table 78: Product Profile - Allure Quadra 100
Table 79: Product Profile - AnalyST Accel 100
Table 80: Product Profile - Assurity 101
Table 81: Product Profile - Current Accel 101
Table 82: Product Profile - Current Plus 102
Table 83: Product Profile - Ellipse 102
Table 84: Product Profile - Endurity 103
Table 85: Product Profile - Fortify Assura 103
Table 86: Product Profile - Fortify 104
Table 87: Product Profile - Microny 104
Table 88: Product Profile - Leadless Pacemaker 105
Table 89: Product Profile - Promote Plus 106
Table 90: Product Profile - Quadra Assura 107
Table 91: Product Profile - Unify Assura 107
Table 92: Product Profile - Unify Quadra 108
Table 93: Product Profile - Unify 108
Table 94: Product Profile - Zephyr 109
Table 95: St. Jude Medical SWOT Analysis, 2012 110

1.2 List of Figures
Figure 1: Pacemaker and CRT-P Market, Global, Company Share (%), 2012 13
Figure 2: ICD and CRT-D Market, Global, Company Share (%), 2012 15
Figure 3: Pacemaker and CRT-P Market, US, Company Share (%), 2012 16
Figure 4: ICD and CRT-D Market, US, Company Share (%), 2012 17
Figure 5: Pacemaker and CRT-P Market, Europe, Company Share (%), 2012 18
Figure 6: ICD and CRT-D Market, Europe, Company Share (%), 2012 19
Figure 7: Pacemaker and CRT-P Market, Emerging Markets, Company Share (%), 2012 20
Figure 8: ICD and CRT-D Market, Emerging Markets, Company Share (%), 2012 21
Figure 9: Pacemaker and CRT-P Market, Japan, Company Share (%), 2012 22
Figure 10: ICD and CRT-D Market, Japan, Company Share (%), 2012 23
Figure 11: CRM Pipeline Products by Phase in Development 24



Companies Mentioned

Biotronik
Boston Scientific
Impulse Dynamics
Medtronic
Sorin Group
St. Jude Medical