I. INTRODUCTION, METHODOLOGY & PRODUCT DEFINITIONS

Study Reliability and Reporting Limitations I-1
Disclaimers I-2
Data Interpretation & Reporting Level I-2
Quantitative Techniques & Analytics I-3
Product Definitions and Scope of Study I-3


II. EXECUTIVE SUMMARY

1. INDUSTRY OVERVIEW II-1
Growing Importance of Intracranial Stents in Neurovascular
Disease II-1
Table 1: Global Neurovascular Intervention Market by
Technique (2014): Percentage Share Breakdown for
Embolization, Revascularization, Support Devices, and
Mechanical Thrombectomy (includes corresponding Graph/Chart) II-1
The Global Intracranial Stents Market - Adversely Impacted by
the SAMMPRIS Study II-2
SAMMPRIS Study: An Insight II-3
Rising Geriatric Population - A Major Growth Driver for the
ICS Market II-4
Table 2: Elderly Population (65+ Years) as a Percentage of
the Total Population: 2000 & 2025 (includes corresponding
Graph/Chart) II-5

Table 3: Global Population Statistics for the 65+ Age Group:
2012 (includes corresponding Graph/Chart) II-6

Table 4: Life Expectancy at Age 60 and 80 Years- (2010-2015),
(2020-2025) & (2045-2050) (includes corresponding
Graph/Chart) II-7
Market Challenges II-7
Technological Challenges II-7
Safety and Efficacy II-7
Regulatory Challenges II-8
Price Factor II-8

2. INTRACRANIAL STENTS AVAILABLE IN THE MARKET II-9
APOLLO Stent System II-9
WILLIS® Intracranial Stent Graft System II-9
Neuroform EZ® Stent System II-9
Wingspan® Stent System II-9
Self-Expandable LEO II-10
Micrus® Pharos™ Vitesse™ Intracranial Stent II-10
Solitaire AB Neurovascular Remodeling Device II-10

3. MARKET DRIVERS & TRENDS II-11
Changing Lifestyle Conditions Stoking Risk of Cerebrovascular
Diseases II-11
Rising Stroke Statistics - An Opportunity Indicator II-11
Rising Number of Restenosis Cases Boosts Demand for Stenting II-12
Asians at Highest Risk of Intracranial Atherosclerosis Disease II-12
Cardiovascular Stent Manufacturers Diversify Into the
Neurovascular Market II-12
QMRA Facilitates Detection of In-stent Stenosis II-13
MNCs Weave Strategies to Tap Growth Centers in Emerging Markets II-13
Medical Tourism Buoys Demand for Stenting Procedures in
Emerging Nations II-14
Rising Road Accidents Lead to Increasing Number of Stenting
Procedures II-14
Table 5: Global Rate of Road Fatalities by Economic Status of
Countries (2014): Percentage Rate of Road Fatalities per
100,000 Residents for Low, Mid and High Per Capita Income
Regions (includes corresponding Graph/Chart) II-15

4. PRODUCT OVERVIEW II-16
Intracranial Stenting II-16
Stents II-16
Evolution II-16
Types of Stents II-17
Bare Metal Stents (BMS) II-17
Drug Eluting Stents II-17
Self-Expanding Stents II-18
Post-Treatment Management II-18
Anti-Platelet Therapy II-18
Surveillance Imaging II-19

5. NEUROVASCULAR DISEASES - AN OVERVIEW II-20
Introduction II-20
Diagnosis of Intracranial Stenosis II-20
Differential Diagnosis II-20
Neuroimaging Screening II-21
Anatomic Diagnosis II-21
Digital Subtraction Angiography II-21
Transcranial Doppler II-21
Magnetic Resonance Angiography (MRA) II-21
Positron Emission Tomography (PET) II-22
Computerized Tomography (CT) Perfusion II-22
Treatment Procedures for Intracranial Stenosis II-22
Medication II-22
Anticoagulants or Blood Thinners II-22
Cholesterol Lowering Drugs II-22
Blood Pressure Medications II-23
Surgical Procedures II-23
Stenting/Balloon Angioplasty II-23
Cerebral Artery Bypass II-23

6. MAJOR NEUROVASCULAR INDICATIONS REQUIRING STENTING PROCEDURES II-24
Ischemic Stroke II-24
Symptoms, Indications, and Complications Associated with Stroke II-24
Posterior Circulation Stroke II-24
Anterior Circulation Stroke II-24
Non-Specific Signs II-24
Some Major Risk Factors for Stroke II-24
Intracranial Atherosclerotic Disease (ICAD) II-25
Risk Factors II-25
Treatment Options for ICAD II-25
Brain Aneurysms/Cerebral Aneurysm/ Intracranial Aneurysm II-26
Aneurysm - Quick Facts II-26
Symptoms of Unruptured Aneurysm II-26
Risk Factors for Aneurysm II-26
Detection Methods II-27
Table 6: Comparison of Sensitivity and Specificity of
Computed Tomography Angiography (CTA), Transcranial Doppler
Sonography (TCD) and Magnetic Resonance Angiography (MRA) in
the Diagnosis of Intracranial Aneurysms (includes
corresponding Graph/Chart) II-27

Table 7: Percentage Mortality, Morbidity, and Re-bleeding
Rate of Intervention Associated with Intracranial Aneurysms II-28
Arterial Dissection II-28
Diagnosis II-28
Treatment II-28
Restenosis II-28

7. PRODUCT INTRODUCTIONS & APPROVALS II-29
CFDA Approves New Specifications of MicroPort's Apollo Stent
System (China) II-29
MicroPort's WILLIS® Intracranial Stent Graft System Receives
China SFDA Approval II-29
Phenox's pCONus Bifurcation Aneurysm Implant Obtains CE-Mark
Approval II-29
Acandis' Acclino 1.9-F Stent System Receives CE Mark Approval II-29
ITGI Medical Obtains CE Mark Approval for AneuGraft Nx II-29

8. RECENT INDUSTRY ACTIVITY II-30
MicroVention Enrolls in Clinical Trial for Its FRED™ System (US) II-30
Admedes Schuessler to Expand Nitinol Manufacturing Capacity II-30
STAR Study Results Establish Safety and Efficacy of Solitaire™
FR Device in Acute Ischemic Stroke Treatment II-30
MicroPort Scientific Announces Inauguration of MicroPort
NeuroTech II-30
Purdue University Scientists Study Stents Coated with
Nanotechnology-Enhanced Drug for Treatment of Aneurysms II-30

9. FOCUS ON SELECT PLAYERS II-31
Admedes Schuessler GmbH (Germany) II-31
BALT Extrusion (France) II-31
Cardiatis SA (Belgium) II-31
Codman & Shurtleff, Inc. (US) II-32
Covidien PLC (Ireland) II-32
ITGI Medical Ltd. (Israel) II-33
MicroPort Scientific Corporation (China) II-33
OBEX Medical (New Zealand) II-34
Stryker Corp. (US) II-34

10. GLOBAL MARKET PERSPECTIVE II-35
Table 8: World Recent Past, Current & Future Analysis for
Intracranial Stents by Geographic Region - US, Europe and Rest
of World Markets Independently Analyzed with Annual Sales
Figures in US$ Thousand for the Years 2013 through 2020
(includes corresponding Graph/Chart) II-35

Table 9: World Historic Review for Intracranial Stents by
Geographic Region - US, Europe and Rest of World Markets
Independently Analyzed with Annual Sales Figures in US$
Thousand for the Years 2006 through 2012 (includes
corresponding Graph/Chart) II-36

Table 10: World 14-Year Perspective for Intracranial Stents by
Geographic Region - Percentage Breakdown of Dollar Sales for
US, Europe and Rest of World Markets for the Years 2006, 2014 &
2020 (includes corresponding Graph/Chart) II-37


III. MARKET

1. THE UNITED STATES III-1
A.Market Analysis III-1
The Largest Market for Intracranial Stents Globally III-1
SAMMPRIS Study Results - A Major Blow to the US ICS Market III-1
Ageing Demographics: A Key Market Driver III-3
Table 11: North American Elderly Population by Age Group:
1975-2050 (includes corresponding Graph/Chart) III-3
Regulatory Status of Intracranial Stents in the United States III-4
Intracranial Stenting among Medicare Beneficiaries during
the Years 2006-2010 III-4
Strategic Corporate Developments III-4
Select Key Players III-5
B.Market Analytics III-7
Table 12: The US Recent Past, Current & Future Analysis for
Intracranial Stents Market Analyzed with Annual Sales
Figures in US$ Thousand for the Years 2013 through 2020
(includes corresponding Graph/Chart) III-7

Table 13: The US Historic Review for Intracranial Stents
Market Analyzed with Annual Sales Figures in US$ Thousand
for the Years 2006 through 2012 (includes corresponding
Graph/Chart) III-8

2. EUROPE III-9
A.Market Analysis III-9
Negative Effects of SAMMPRIS Study Expand to European Market III-9
Increasing Geriatric Population Segment: A Business Case for
ICS III-9
Table 14: Population Breakup by Age Group for Select
European Countries: 2012 (As a % of Total Population)
(includes corresponding Graph/Chart) III-10
Focus on Select Regional Markets III-11
France III-11
French Government Imposes Regulations on Advertisement of
High-risk Medical Devices III-11
The United Kingdom III-11
Stroke Statistics in the UK III-11
Table 15: Breakdown of Total Number of Deaths Due to
Strokes by Age and Sex in the UK: 2010 (includes
corresponding Graph/Chart) III-11
Product Approvals III-12
Strategic Corporate Development III-12
Select Key Players III-12
B.Market Analytics III-14
Table 16: European Recent Past, Current & Future Analysis
for Intracranial Stents Market Analyzed with Annual Sales
Figures in US$ Thousand for the Years 2013 through 2020
(includes corresponding Graph/Chart) III-14

Table 17: European Historic Review for Intracranial Stents
Market Analyzed with Annual Sales Figures in US$ Thousand
for the Years 2006 through 2012 (includes corresponding
Graph/Chart) III-15

3. REST OF WORLD III-16
A.Market Analysis III-16
Developing Regions Poised to Witness Faster Growth III-16
Price Sensitivity of Asian Consumers - A Crucial Factor III-16
India & China Offer Significant Growth Opportunities III-16
Table 18: China and India Leads Global Population (July
2013): Table Depicting China and India's Huge Population
Vis-a-vis Other Countries' Population (in Million) by Age
Group (includes corresponding Graph/Chart) III-17

Table 19: Age-wise Breakup of China and India's Population
Vis-à-vis Other Populous Countries Globally: As of July
2013 (includes corresponding Graph/Chart) III-18
Select Regional Markets III-18
Australia III-18
Stroke Statistics in Australia III-18
Table 20: Stroke Prevalence in Australia Age and Gender:
2012 (includes corresponding Graph/Chart) III-19
Leading Risk Factors for Stroke-Related Fatalities:
Ranking Based on Number of Deaths (2012) III-19
China III-19
Healthcare Reforms and New Product Approval to Propel
Market Growth III-19
Table 21: Chinese Neurovascular Stents Market by Leading
Brand (2013): Percentage Market Share Breakdown of Units
Sold for Apollo, Wingspan, and Others (includes
corresponding Graph/Chart) III-20
APOLLO - Tried and tested Stent System III-20
WILLIS® to Target Bright Market Prospects in China III-20
India III-21
Changes in Lifestyle Demographic and Socioeconomic Factors
Increase Stroke Prevalence III-21
Stroke Statistics III-21
Management and Treatment of Stroke Presents a Daunting Task III-21
Kerala - Gaining Prominence for Neurovascular Therapy III-21
Japan III-22
Japanese Intracranial Stents Market III-22
Table 22: Japanese Elderly (65+ Years) Population:
2000-2020 (includes corresponding Graph/Chart) III-22
Studies Validate Effectiveness of Endovascular Therapy for
Treatment of Intracranial Aneurysm III-23
Product Approvals III-23
Strategic Corporate Development III-24
Select Key Players III-24
B.Market Analytics III-26
Table 23: Rest of World Recent Past, Current & Future
Analysis for Intracranial Stents Market Analyzed with Annual
Sales Figures in US$ Thousand for the Years 2013 through
2020 (includes corresponding Graph/Chart) III-26

Table 24: Rest of World Historic Review for Intracranial
Stents Market Analyzed with Annual Sales Figures in US$
Thousand for the Years 2006 through 2012 (includes
corresponding Graph/Chart) III-27


IV. COMPETITIVE LANDSCAPE

Total Companies Profiled: 14 (including Divisions/Subsidiaries - 17)

The United States (6)
Europe (6)
- France (1)
- Germany (3)
- Rest of Europe (2)
Asia-Pacific (Excluding Japan) (4)
Middle East (1)