1 Table of Contents
1 Table of Contents 2
1.1 List of Tables 5
1.2 List of Figures 7
2 Introduction 8
2.1 CSF Management Overview 8
3 Products under Development 9
3.1 Cerebro Spinal Fluid Management - Pipeline Products by Stage of Development 9
3.2 Cerebro Spinal Fluid Management - Pipeline Products by Segment 10
3.3 Cerebro Spinal Fluid Management - Pipeline Products by Territory 11
3.4 Cerebro Spinal Fluid Management - Pipeline Products by Regulatory Path 12
3.5 Cerebro Spinal Fluid Management - Pipeline Products by Estimated Approval Date 13
3.6 Cerebro Spinal Fluid Management - Ongoing Clinical Trials 14
4 Cerebro Spinal Fluid Management - Pipeline Products under Development by Companies 15
4.1 Cerebro Spinal Fluid Management Companies - Pipeline Products by Stage of Development 15
4.2 Cerebro Spinal Fluid Management - Pipeline Products by Stage of Development 17
5 Cerebro Spinal Fluid Management Companies and Product Overview 19
5.1 Alcyone Lifesciences, Inc. Company Overview 19
5.1.1 Alcyone Lifesciences, Inc. Pipeline Products & Ongoing Clinical Trials Overview 19
5.2 Aqueduct Neurosciences Company Overview 22
5.2.1 Aqueduct Neurosciences Pipeline Products & Ongoing Clinical Trials Overview 22
5.3 Arkis BioSciences Company Overview 24
5.3.1 Arkis BioSciences Pipeline Products & Ongoing Clinical Trials Overview 24
5.4 Beckersmith Medical, Inc. Company Overview 25
5.4.1 Beckersmith Medical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 25
5.5 Biosan Medical Ltd. Company Overview 26
5.5.1 Biosan Medical Ltd. Pipeline Products & Ongoing Clinical Trials Overview 26
5.6 Georgia Institute of Technology Company Overview 28
5.6.1 Georgia Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 28
5.7 H-Cubed Inc. Company Overview 30
5.7.1 H-Cubed Inc. Pipeline Products & Ongoing Clinical Trials Overview 30
5.8 Integra LifeSciences Holdings Corporation Company Overview 31
5.8.1 Integra LifeSciences Holdings Corporation Pipeline Products & Ongoing Clinical Trials Overview 31
5.9 InVivo Therapeutics Corporation Company Overview 35
5.9.1 InVivo Therapeutics Corporation Pipeline Products & Ongoing Clinical Trials Overview 35
5.10 Kerecis ehf Company Overview 38
5.10.1 Kerecis ehf Pipeline Products & Ongoing Clinical Trials Overview 38
5.11 Microbot Medical, Ltd. Company Overview 39
5.11.1 Microbot Medical, Ltd. Pipeline Products & Ongoing Clinical Trials Overview 39
5.12 Nanonerve Inc. Company Overview 41
5.12.1 Nanonerve Inc. Pipeline Products & Ongoing Clinical Trials Overview 41
5.13 NeuraMedica, LLC Company Overview 42
5.13.1 NeuraMedica, LLC Pipeline Products & Ongoing Clinical Trials Overview 42
5.14 NexGen Medical Systems, Inc. Company Overview 43
5.14.1 NexGen Medical Systems, Inc. Pipeline Products & Ongoing Clinical Trials Overview 43
5.15 Sree Chitra Tirunal Institute for Medical Sciences & Technology Company Overview 44
5.15.1 Sree Chitra Tirunal Institute for Medical Sciences & Technology Pipeline Products & Ongoing Clinical Trials Overview 44
5.16 System Science Inc. Company Overview 46
5.16.1 System Science Inc. Pipeline Products & Ongoing Clinical Trials Overview 46
5.17 University Hospital Zurich Company Overview 48
5.17.1 University Hospital Zurich Pipeline Products & Ongoing Clinical Trials Overview 48
5.18 University of Rochester Company Overview 50
5.18.1 University of Rochester Pipeline Products & Ongoing Clinical Trials Overview 50
5.19 University of South Florida Company Overview 51
5.19.1 University of South Florida Pipeline Products & Ongoing Clinical Trials Overview 51
5.20 University of Wisconsin Madison Company Overview 53
5.20.1 University of Wisconsin Madison Pipeline Products & Ongoing Clinical Trials Overview 53
5.21 Vivonics, Inc. Company Overview 55
5.21.1 Vivonics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 55
5.22 Wayne State University Company Overview 57
5.22.1 Wayne State University Pipeline Products & Ongoing Clinical Trials Overview 57
6 Cerebro Spinal Fluid Management- Recent Developments 59
6.1 Oct 26, 2016: LeMaitre Q3 2016 Record Sales $23.2 mm (+22%), Record Op. Income $5.3 mm (+61%) 59
6.2 Oct 12, 2016: HyperBranch Medical Wins Decision Against Integra Lifesciences 59
6.3 Sep 15, 2016: Medtronic Names Mark Ploof Senior Vice President of Global Operations and Business Services 60
6.4 Aug 31, 2016: Cook Medical Names Jean-Marc Creissel Vice President of Operations in Greater China 61
6.5 Aug 25, 2016: Medtronic Reports First Quarter Financial Results 61
6.6 Aug 15, 2016: Studies Show That the Kerecis Fish Skin Reduces Infections and Preserves Tissue Viability 64
6.7 Aug 15, 2016: StemCells to Acquire Microbot Medical 64
6.8 Aug 11, 2016: InVivo Therapeutics Appoints Pamela Stahl as Chief Commercial Officer 65
6.9 Aug 09, 2016: Alcyone Lifesciences, Announces Allowance of First Patent Related to ReFlow System for the Treatment of Hydrocephalus 66
6.10 Aug 04, 2016: InVivo Therapeutics Reports 2016 Second Quarter Financial Results and Business Update 67
6.11 Aug 02, 2016: Alcyone Lifesciences Announces Clinical Use of the ReFlow System for the Treatment of Hydrocephalus 68
6.12 Jul 28, 2016: Integra LifeSciences Reports Second Quarter 2016 Financial Results 68
6.13 Jul 27, 2016: LeMaitre Q2 2016 Record Sales $22.4mm (+13%), Record Op. Income $3.8mm (+35%) 70
6.14 Jun 30, 2016: NuVasive Agrees to Settle Patent Litigation With Medtronic 70
6.15 Jun 24, 2016: Arkis BioSciences Raises USD3.4 Million in Series A Venture Financing 71
6.16 Jun 06, 2016: Medtronic Outlines Future Growth Vision at Investor Day 71
6.17 May 31, 2016: Medtronic Reports Fourth Quarter and Fiscal Year 2016 Financial Results 71
6.18 May 02, 2016: Medtronic Expands MRI-Compatible Portfolio With FDA Clearance Of StrataMR Shunt System 74
6.19 Apr 27, 2016: Integra LifeSciences Reports First Quarter 2016 Financial Results 74
6.20 Feb 25, 2016: Integra LifeSciences Reports Fourth Quarter and Full Year 2015 Financial Results and Issues 2016 Full Year Guidance 76
6.21 Nov 03, 2015: Integra LifeSciences Reports Third Quarter 2015 Financial Results 77
7 Appendix 78
7.1 Methodology 78
7.2 About GlobalData 80
7.3 Contact Us 81
7.4 Disclaimer 81

1.1 List of Tables
Table 1: Cerebro Spinal Fluid Management - Pipeline Products by Stage of Development 9
Table 2: Cerebro Spinal Fluid Management - Pipeline Products by Segment 10
Table 3: Cerebro Spinal Fluid Management - Pipeline Products by Territory 11
Table 4: Cerebro Spinal Fluid Management - Pipeline Products by Regulatory Path 12
Table 5: Cerebro Spinal Fluid Management - Pipeline Products by Estimated Approval Date 13
Table 6: Cerebro Spinal Fluid Management - Ongoing Clinical Trials 14
Table 7: CSF Management Companies - Pipeline Products by Stage of Development 15
Table 8: Cerebro Spinal Fluid Management - Pipeline Products by Stage of Development 17
Table 9: Alcyone Lifesciences, Inc. Pipeline Products & Ongoing Clinical Trials Overview 19
Table 10: ReFlow System - Product Status 19
Table 11: ReFlow System - Product Description 19
Table 12: Alcyone Lifesciences, Inc. - Ongoing Clinical Trials Overview 20
Table 13: ReFlow System - Quantitative Characterization of Safe Irrigation for Ventricular Shunt Catheters 21
Table 14: Aqueduct Neurosciences Pipeline Products & Ongoing Clinical Trials Overview 22
Table 15: Smart External Drainage System - Product Status 22
Table 16: Smart External Drainage System - Product Description 22
Table 17: Smart Shunt - Product Status 23
Table 18: Smart Shunt - Product Description 23
Table 19: Arkis BioSciences Pipeline Products & Ongoing Clinical Trials Overview 24
Table 20: Arkis AutoShunt - Product Status 24
Table 21: Arkis AutoShunt - Product Description 24
Table 22: Beckersmith Medical, Inc. Pipeline Products & Ongoing Clinical Trials Overview 25
Table 23: FlowSafe - Product Status 25
Table 24: FlowSafe - Product Description 25
Table 25: Biosan Medical Ltd. Pipeline Products & Ongoing Clinical Trials Overview 26
Table 26: Ventritek105 - Product Status 26
Table 27: Ventritek105 - Product Description 26
Table 28: Georgia Institute of Technology Pipeline Products & Ongoing Clinical Trials Overview 28
Table 29: Hydrocephalus Shunt - Product Status 28
Table 30: Hydrocephalus Shunt - Product Description 28
Table 31: H-Cubed Inc. Pipeline Products & Ongoing Clinical Trials Overview 30
Table 32: Ambulatory System For Hydrocephalus Shunt - Product Status 30
Table 33: Ambulatory System For Hydrocephalus Shunt - Product Description 30
Table 34: Integra LifeSciences Holdings Corporation Pipeline Products & Ongoing Clinical Trials Overview 31
Table 35: Hydrocephalic Shunt - Product Status 31
Table 36: Hydrocephalic Shunt - Product Description 31
Table 37: Next Generation DuraGen - Product Status 32
Table 38: Next Generation DuraGen - Product Description 32
Table 39: Next Generation DuraSeal - Product Status 32
Table 40: Next Generation DuraSeal - Product Description 33
Table 41: Ventricular Drainage Device - Product Status 33
Table 42: Ventricular Drainage Device - Product Description 33
Table 43: InVivo Therapeutics Corporation Pipeline Products & Ongoing Clinical Trials Overview 35
Table 44: DuraGraft - Product Status 35
Table 45: DuraGraft - Product Description 35
Table 46: InVivo Therapeutics Corporation - Ongoing Clinical Trials Overview 36
Table 47: DuraGraft - A Study to Evaluate the Use of SOMVC001 (GALA) Vascular Conduit Preservation Solution in Patients Undergoing Coronary Artery Bypass Grafting (CABG) 37
Table 48: Kerecis ehf Pipeline Products & Ongoing Clinical Trials Overview 38
Table 49: Kerecis Omega3 Dura - Product Status 38
Table 50: Kerecis Omega3 Dura - Product Description 38
Table 51: Microbot Medical, Ltd. Pipeline Products & Ongoing Clinical Trials Overview 39
Table 52: Microbot Self-Cleaning Shunt (SCS) device - Product Status 39
Table 53: Microbot Self-Cleaning Shunt (SCS) device - Product Description 39
Table 54: Nanonerve Inc. Pipeline Products & Ongoing Clinical Trials Overview 41
Table 55: Nanofibrous Dural Substitute - Product Status 41
Table 56: Nanofibrous Dural Substitute - Product Description 41
Table 57: NeuraMedica, LLC Pipeline Products & Ongoing Clinical Trials Overview 42
Table 58: Dural Clip - Product Status 42
Table 59: Dural Clip - Product Description 42
Table 60: NexGen Medical Systems, Inc. Pipeline Products & Ongoing Clinical Trials Overview 43
Table 61: EViTAR FLOWMETER - Product Status 43
Table 62: EViTAR FLOWMETER - Product Description 43
Table 63: Sree Chitra Tirunal Institute for Medical Sciences & Technology Pipeline Products & Ongoing Clinical Trials Overview 44
Table 64: Bovine Pericardium - Dura Substitute - Product Status 44
Table 65: Bovine Pericardium - Dura Substitute - Product Description 44
Table 66: Programmable Hydrocephalus Stent - Product Status 45
Table 67: Programmable Hydrocephalus Stent - Product Description 45
Table 68: System Science Inc. Pipeline Products & Ongoing Clinical Trials Overview 46
Table 69: Acute Cerebro Spinal Fluid Monitor And Control System - Product Status 46
Table 70: Acute Cerebro Spinal Fluid Monitor And Control System - Product Description 46
Table 71: Implantable Cerebro Spinal Fluid Monitor And Control System - Product Status 47
Table 72: Implantable Cerebro Spinal Fluid Monitor And Control System - Product Description 47
Table 73: University Hospital Zurich Pipeline Products & Ongoing Clinical Trials Overview 48
Table 74: SmartShunt - Product Status 48
Table 75: SmartShunt - Product Description 48
Table 76: University of Rochester Pipeline Products & Ongoing Clinical Trials Overview 50
Table 77: Catheterless Shunt System - Product Status 50
Table 78: Catheterless Shunt System - Product Description 50
Table 79: University of South Florida Pipeline Products & Ongoing Clinical Trials Overview 51
Table 80: Shunt Catheter System With Inline Filter - Product Status 51
Table 81: Shunt Catheter System With Inline Filter - Product Description 51
Table 82: Sonic Window Cranioplasty Implant - Product Status 52
Table 83: Sonic Window Cranioplasty Implant - Product Description 52
Table 84: University of Wisconsin Madison Pipeline Products & Ongoing Clinical Trials Overview 53
Table 85: Gravity And Pressure Controlled Valve System - Product Status 53
Table 86: Gravity And Pressure Controlled Valve System - Product Description 53
Table 87: Hydrocephalus Stent - Product Status 54
Table 88: Hydrocephalus Stent - Product Description 54
Table 89: Vivonics, Inc. Pipeline Products & Ongoing Clinical Trials Overview 55
Table 90: Micro Fabricated Implantable Flowmeter - Cerebro Spinal Fluid (CSF) Shunt - Product Status 55
Table 91: Micro Fabricated Implantable Flowmeter - Cerebro Spinal Fluid (CSF) Shunt - Product Description 55
Table 92: Shunt Flowmeter - Product Status 56
Table 93: Shunt Flowmeter - Product Description 56
Table 94: Wayne State University Pipeline Products & Ongoing Clinical Trials Overview 57
Table 95: Programmable Antisiphon Shunt System - Product Status 57
Table 96: Programmable Antisiphon Shunt System - Product Description 57
Table 97: Glossary 79

1.2List of Figures
Figure 1: Cerebro Spinal Fluid Management - Pipeline Products by Stage of Development 9
Figure 2: Cerebro Spinal Fluid Management - Pipeline Products by Segment 10
Figure 3: Cerebro Spinal Fluid Management - Pipeline Products by Territory 11
Figure 4: Cerebro Spinal Fluid Management - Pipeline Products by Regulatory Path 12
Figure 5: Cerebro Spinal Fluid Management - Pipeline Products by Estimated Approval Date 13
Figure 6: Cerebro Spinal Fluid Management - Ongoing Clinical Trials 14