Table of Contents

Executive Summary ES?1
i. Cardiovascular diseases overviewES?1
ii. Global vascular access site closure products marketES?1
a. Market drivers and limitersES?3
b. Device segment insights ES?4
c. Technology trendsES?4
d. Market leadersES?5
e. Competitive strategiesES?5
f. Emerging competition ES?6
iii. MethodologyES?6

Exhibit ES?1: Vascular access site closure products, global market forecast, 2017?22 ES?2
Exhibit ES?2: Global vascular access site closure products market, share  by country/region, 2017 ES?3
Exhibit ES?3: Drivers and limiters of growth – vascular access site closure products ES?4

1. Cardiovascular Diseases Overview 1?1
1.1 Acute coronary syndrome 1?3
1.1.1 Atherosclerosis 1?5
1.1.2 Angina pectoris 1?6
1.1.3 Myocardial infarction 1?7
1.1.4 Diagnosis and treatment 1?9
1.2 Hypertension 1?10
1.3 Heart failure 1?12
1.4 Peripheral vascular disease 1?15
1.4.1 Critical limb ischemia 1?17
1.4.2 Aneurysm 1?17
1.4.3 Deep vein thrombosis/pulmonary embolism 1?18
1.4.4 Diagnosis and treatment 1?19
1.5 Cerebrovascular disease 1?20
1.5.1 Diagnosis and treatment 1?25
1.6 Bibliography 1?26

Exhibit 1?1: Estimated deaths attributable to cardiovascular disease, select countries, 2016 1?1
Exhibit 1?2: Top 10 countries with the highest CVD death rates for males and females 1?2
Exhibit 1?3: Estimated incident cases for acute coronary syndrome, select continents, 2017 1?4
Exhibit 1?4: Estimated deaths attributable to ischemic heart disease, select countries, 2016 1?5
Exhibit 1?5: Age?standardized incidence (per 100,000) of angina pectoris, select regions,  1990 and 2010 1?7
Exhibit 1?6: Clinical classification of acute myocardial infarction 1?8
Exhibit 1?7: Age?standardized incidence (per 100,000) of acute myocardial infarction,  select regions, 1990 and 2010 1?9
Exhibit 1?8: Estimated prevalent cases of hypertension, select countries, 2017 1?11
Exhibit 1?9: Estimated deaths attributable to hypertensive heart disease,  select countries, 2016 1?12
Exhibit 1?10: Estimated incidence of acute decompensated heart failure,  select countries, 2017 1?14
Exhibit 1?11: Estimated prevalent cases of chronic heart failure, select countries, 2017 1?15
Exhibit 1?12: Estimated prevalence of peripheral artery disease, select countries, 2016 1?16
Exhibit 1?13: Estimated incident cases of DVT, select countries, 2017 1?18
Exhibit 1?14: Estimated incident cases of PE, select countries, 2017 1?19
Exhibit 1?15: Estimated incident cases of ischemic stroke, select countries, 2017 1?22
Exhibit 1?16: Estimated incident cases of hemorrhagic stroke, select countries, 2017 1?23
Exhibit 1?17: Estimated prevalent cases of ischemic stroke, select countries, 2017 1?24
Exhibit 1?18: Estimated prevalent cases of hemorrhagic stroke, select countries, 2017 1?25

2. Vascular Access Site Closure Products 2?1
2.1 Types of vascular closure products 2?1
2.1.1 Advantages and disadvantages 2?2
2.2 Vascular closure devices 2?3
2.3 Hemostatic compressive devices 2?5
2.4 Other hemostatic products 2?5
2.5 Bibliography 2?7

Exhibit 2?1: Advantages and disadvantages of vascular closure devices 2?3
Exhibit 2?2: Selected vascular closure devices 2?4
Exhibit 2?3: Selected hemostatic compressive devices 2?5
Exhibit 2?4: Selected hemostatic products for the management of vascular access sites 2?6

3. Vascular Access Site Closure Products Market 3?1
3.1 Global market insights 3?1
3.1.1 Market value 3?1
3.1.2 Technology trends 3?4
3.1.3 Market drivers and limiters 3?5
3.1.4 Vascular access site closure products overview 3?9
3.1.5 Market leaders 3?10
3.1.6 Competitive strategies 3?11
3.1.7 Emerging competition 3?12
3.2 Global competitors 3?12
3.3 Market forecast 3?14
3.3.1 Market forecast: US 3?14
3.3.2 Market forecast: five major EU markets 3?20
3.3.3 Market forecast: Japan 3?26
3.3.4 Market forecast: Rest of the world 3?30
3.4 Primary research 3?33
3.5 Bibliography 3?37

Exhibit 3?1: Vascular access site closure products, global market forecast, 2017?22 3?2
Exhibit 3?2: Global vascular access site closure products market, share by country/region, 2017 3?3
Exhibit 3?3: Global vascular access site closure product sales, combined market forecast ($m), by country/region, 2017?22 3?4
Exhibit 3?4: Drivers and limiters of market growth – vascular access site closure products 3?9
Exhibit 3?5: Vascular access site closure products, share by product type, for 2017 and 2022 3?10
Exhibit 3?6: Global vascular access site closure products market, share by supplier, 2017 3?14
Exhibit 3?7: US minimally invasive interventional cardiology, procedure volumes forecast (000s), 2017?22 3?16
Exhibit 3?8: US vascular access site closure products, estimated procedure volumes forecast (000s), 2017?22 3?17
Exhibit 3?9: US vascular access site closure product sales, estimated  market forecast ($m), 2017?22 3?18
Exhibit 3?10: US vascular access site closure products market, share by supplier, 2017 3?19
Exhibit 3?11: 5EU minimally invasive interventional cardiology, procedure volumes  forecast (000s), 2017?22 3?22
Exhibit 3?12: 5EU vascular access site closure products, estimated procedure volumes  forecast (000s), 2017?22 3?23
Exhibit 3?13: 5EU vascular access site closure product sales, estimated market  forecast ($m), 2017?22 3?24
Exhibit 3?14: 5EU vascular access site closure products market, share by supplier, 2017 3?25
Exhibit 3?15: Japanese minimally invasive interventional cardiology, procedure volumes  forecast (000s), 2017?22 3?27
Exhibit 3?16: Japanese vascular access site closure products, estimated procedure volumes  forecast (000s), 2017?22 3?28
Exhibit 3?17: Japanese vascular access site closure product sales, estimated  market forecast ($m), 2017?22 3?29
Exhibit 3?18: Japanese vascular access site closure products market, share by supplier, 2017 3?30
Exhibit 3?19: RoW vascular access site closure product sales, estimated market  forecast ($m), 2017?22 3?31
Exhibit 3?20: RoW vascular access site closure products market, share by supplier, 2017 3?33
Exhibit 3?21: Reported average number of interventional cardiology procedures performed  monthly – survey results 3?34
Exhibit 3?22: Reported average utilization of vascular access site closure products, by  region – survey results 3?35
Exhibit 3?23: Reported average utilization of vascular access sites, by region – survey results 3?35

Appendix: Company Listing A?1