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The MTD was not reached during this phase of the trial, and the majority of adverse events were mild or moderate gastrointestinal or hematological toxicities.
GLP-## agonists have been associated with a common side effect of gastrointestinal disturbances such as nausea and vomiting, which can reduce patient compliance (Prasad-Reddy and Isaacs, 2015).
Minor AEs such as stomatitis, headaches, fatigue and gastrointestinal problems such as nausea and vomiting may occur when using Metolate.
Gastrointestinal Cancer Research; ##(##): ##-## Mayo Clinic (2014).
When gastrointestinal AEs were reported their intensity was much lower than with oxycodone.
As such, non-selective COX inhibitors typically produce COX-## inhibitory gastrointestinal (GI) side effects, including gastric ulceration, bleeding and perforation.
Phase I failure rates ranged broadly from ##% in immunology and ##% in gastrointestinal disorders to ##% in musculoskeletal disorders.
AS CF IS A MULTI-SYSTEM DISEASE, EVEN IF THE LUNG TRANSPLANT IS SUCCESSFUL, PANCREATIC, GASTROINTESTINAL AND REPRODUCTIVE PROBLEMS WILL REMAIN.
As previously outlined, Xenical is a gastrointestinal lipase inhibitor that acts specifically in the lumen of the stomach and small intestine.
This method avoids the gastrointestinal tract and leads to more rapid effects, compared to orally administered levodopa.
Dietary factors have a substantial influence on the risk of cancers of the gastrointestinal tract.
Gastrointestinal Cancer Research; ##(##): ##-## Hurwitz H, et al. (2004).
GASTROINTESTINAL EVENTS SUCH AS NAUSEA AND DIARRHEA OCCURRED MOST FREQUENTLY.
It is also in development within the gastrointestinal disease area.
Minor AEs such as stomatitis, headaches, fatigue and gastrointestinal problems such as nausea and vomiting may occur when using methotrexate.
In contrast, Tykerb (lapatinib), which also targets HER##, has a very low associated incidence of cardiac AEs and is instead more frequently associated with skin and gastrointestinal events.