About 500 reports

Immunotoxicity of monoclonal antibodies. mAbs; ##(##): ##-## Duan C, et al. (2015).

  • Monoclonal Antibody
  • AbbVie Inc.
  • Bristol-Myers Squibb Company
  • Genentech, Inc.
  • Johnson & Johnson

" I' m intrigued by the anti-tau monoclonal antibodies.

  • Monoclonal Antibody
  • United States
  • Eisai Co., Ltd.
  • Novartis AG
  • Roche Group

For example, anti-fibrillin-## antibodies can activate fibroblasts, and antibodies to matrix metalloproteinase-## (MMP-##) and MMP-## can prevent the breakdown of excessive collagen.

  • Monoclonal Antibody
  • AbbVie Inc.
  • Amryt Pharma plc
  • Celgene Corporation
  • Fibrocell Science, Inc.

RANDOMIZED PHASE I TRIALS OF THE SAFETY/ TOLERABILITY OF ANTI-LINGO-## MONOCLONAL ANTIBODY BIIB##.

  • Monoclonal Antibody
  • United States
  • Forecast
  • Biogen Idec Inc.
  • Novartis AG

Alzumab is an anti-CD## monoclonal antibody.

  • Monoclonal Antibody
  • Market Size
  • AbbVie Inc.
  • Janssen Biotech, Inc.
  • Novartis AG

CRC. ##. ## Anti-angiogenesis Therapies ##. ##. ## AVASTIN (BEVACIZUMAB) - ROCHE Avastin is a recombinant, humanized, monoclonal immunoglobulin (IgG) ## antibody developed by Roche.

  • Chemotherapy
  • Monoclonal Antibody
  • Therapy
  • Market Size
  • Merck & Co., Inc.

Distinct PD-L## binding characteristics of therapeutic monoclonal antibody durvalumab.

  • Cancer
  • Monoclonal Antibody
  • AstraZeneca PLC
  • Novartis AG
  • Roche Group

THESE TWO THERAPIES ARE MONOCLONAL ANTIBODY (MAB) PRODUCTS THAT TARGET INTERLEUKIN RECEPTORS, AND TYPIFY THE GROWING PROMINENCE OF MABS IN THE TREATMENT OF RESPIRATORY DISEASES.

  • Monoclonal Antibody
  • Market Size
  • Astellas Pharma Inc.
  • AstraZeneca PLC
  • Biologics, Inc.

Monoclonal antibodies (mAbs) are the newest class of drugs, predominately used in the treatment of psoriasis.

  • Monoclonal Antibody
  • AbbVie Inc.
  • Allergan plc
  • Amgen Inc.
  • Apricus Biosciences, Inc.

TWO MONOCLONAL ANTIBODY (MAB) THERAPIES ARE UNDERGOING CLINICAL TRIALS, ONE OF WHICH IS IN PHASE III.

  • Monoclonal Antibody
  • United States
  • Forecast
  • Novartis AG
  • Pfizer Inc.

UNLIKE THE GENERICS OF SMALL MOLECULES, WHICH ARE OFTEN PRICED AT A SUBSTANTIAL DISCOUNT TO THE ORIGINATOR BRAND, BIOSIMILARS OF THE MONOCLONAL ANTIBODY (MAB) THERAPIES FOR PLAQUE PSORIASIS ARE PRICED ONLY MARGINALLY LOWER THAN THE CORRESPONDING BIOLOGIC BRAND.

  • Monoclonal Antibody
  • United States
  • Merck & Co., Inc.
  • Novartis AG
  • Pfizer Inc.

CANADIAN KEY OPINION LEADER MOST OF THE CURRENT PHASE III REGISTRATIONAL TRIALS THAT ARE INVESTIGATING COMBINATION THERAPIES INVOLVE AT LEAST ONE ANTI-CD## MONOCLONAL ANTIBODY.

  • Monoclonal Antibody
  • AbbVie Inc.
  • Celgene Corporation
  • Gilead Sciences, Inc.
  • Roche Group

CD##+ T cells secrete cytokines that increase antibody production by B cells.

  • Monoclonal Antibody
  • Bristol-Myers Squibb Company
  • Gilead Sciences, Inc.
  • Merck & Co., Inc.
  • Roche Group

HL-## is a fully human monoclonal antibody targeting IgG Receptor FcRn Large Subunit p##.

  • Immunotherapy
  • Monoclonal Antibody
  • Therapy
  • United States
  • World

ELI LILLY' S MIRIKIZIMAB IS A HUMANIZED MONOCLONAL ANTIBODY THAT SELECTIVELY BINDS TO THE P## SUBUNIT UNIQUE TO CYTOKINE IL-##, NEUTRALIZING ITS ACTIVITY.

  • Monoclonal Antibody
  • AbbVie Inc.
  • Janssen Biotech, Inc.
  • Pfizer Inc.
  • Remicade group

Riken LY-## LYC-## LYC-## MaaT-## melittin menadione sodium bisulfite mesalamine MGL-## Monoclonal Antibodies to Antagonize Metallothioneins for Ulcerative Colitis and Crohn' s Disease Monoclonal Antibodies to Antagonize TGF-Beta Receptor Type-

  • Monoclonal Antibody
  • Market Size
  • AbbVie Inc.
  • AstraZeneca PLC
  • Takeda Pharmaceutical Company Limited

Monoclonal antibodies had one deal with an undisclosed deal value.

  • Monoclonal Antibody
  • Forecast
  • Market Size
  • Allergan plc
  • Clearside Biomedical, Inc.

It may not be absolutely high efficacy like the monoclonal antibodies.

  • Monoclonal Antibody
  • United States
  • Forecast
  • Novartis AG
  • TG Therapeutics, Inc.

s PD-## antibody Keytruda.

  • Monoclonal Antibody
  • Market Size
  • AstraZeneca PLC
  • Bristol-Myers Squibb Company
  • Merck & Co., Inc.

Monoclonal antibodies dominated the RA licensing deals market, accounting for ## of the ## deals (##. ##%).

  • Monoclonal Antibody
  • Market Size
  • AbbVie Inc.
  • Galapagos NV
  • Pfizer Inc.

Monoclonal antibodies have a strong presence in the Preclinical, Phase I, Phase II and Phase III stages of development.

  • Monoclonal Antibody
  • AstraZeneca PLC
  • Boehringer Ingelheim GmbH
  • GlaxoSmithKline plc
  • Novartis AG

WITH MOST OF THE PHASE I DRUGS BEING MONOCLONAL ANTIBODIES, THIS STILL REMAINS THE MOLECULE TYPE OF CHOICE FOR FUTURE DRUG DEVELOPMENT. ## Source: GlobalData, Pharma Intelligence Center [Accessed May 2018] ## ## ## ## ## ## ## ## ## ## ## ## Fusion Protein

  • Monoclonal Antibody
  • AbbVie Inc.
  • Eli Lilly & Co.
  • Novartis AG
  • Pfizer Inc.

Herceptin is a monoclonal antibody targeting the HER## receptor.

  • Monoclonal Antibody
  • Company
  • Novartis AG
  • Pfizer Inc.
  • Roche Group

This segment consists largely of premium systemic monoclonal antibodies (mAb), which are highly commercially successful due to their widespread use and high cost.

  • Monoclonal Antibody
  • AbbVie Inc.
  • Eli Lilly & Co.
  • Janssen Biotech, Inc.
  • Johnson & Johnson

IT IS GUT-SELECTIVE MONOCLONAL ANTIBODY AND HAS SUPERIOR SAFETY PROFILE COMPARED TO ANTI-TNFS.

  • Monoclonal Antibody
  • Market Size
  • EA Pharma Co., Ltd.
  • Pfizer Inc.
  • Remicade group

Tysabri is a recombinant humanized immunoglobulin (IgG##) monoclonal antibody (mAb).

  • Monoclonal Antibody
  • Biogen Idec Inc.
  • Novartis AG
  • Roche Group
  • Sanofi S.A.

Figure ##: Cancer Supportive Care Market, Global, Annual Revenue for Neulasta ($bn), 2011- ##. ## Xgeva (denosumab) - Amgen Xgeva (denosumab) is a human monoclonal antibody (mAb) approved in 2010 to help prevent skeletal-related events (SRE) in patients with cancer that had metastasize

  • Monoclonal Antibody
  • Amgen Inc.
  • Daiichi Sankyo Company
  • Eli Lilly & Co.
  • Insys Therapeutics, Inc.

KEYTRUDA, A HUMANIZED ANTI-PD-## MONOCLONAL ANTIBODY, BINDS TO PD-## RECEPTORS AND BLOCKS THEM FROM THE INHIBITORY EFFECT OF PD-## LIGANDS, PROMOTING A T-CELL RESPONSE.

  • Monoclonal Antibody
  • Eli Lilly & Co.
  • Merck & Co., Inc.
  • Roche Group
  • Taiho Pharmaceutical Co., Ltd.

Figure ##: Pharmaceutical Industry, Clinical Trial Duration in Phase II by Molecule Type, 2006- Source: GBI Research, Proprietary Clinical Trials Database, GBI Research Analysis Abbreviations: mAb: monoclonal antibody Source: GBI Research, Proprietary Clinical Trials Database, GBI

  • Clinical Trial
  • Monoclonal Antibody
  • Pharmaceutical
  • Therapy
  • Market Size

Herceptin is the gold standard monoclonal antibody (mAb) for the treatment of HER##positive disease, and is prescribed in nearly all settings.

  • Monoclonal Antibody
  • Market Size
  • AstraZeneca PLC
  • Genentech, Inc.
  • Novartis AG