About 100 reports

For example, anti-fibrillin-## antibodies can activate fibroblasts, and antibodies to matrix metalloproteinase-## (MMP-##) and MMP-## can prevent the breakdown of excessive collagen.

  • Ambulatory Care
  • AbbVie Inc.
  • Amryt Pharma plc
  • Celgene Corporation
  • Fibrocell Science, Inc.

Stem Cell Therapy Peptide Fusion Protein Antisense RNAi Oligonucleotide Antibody Synthetic Peptide Recombinant Protein Protein Biologic Antisense Oligonucleotide Monoclonal Antibody Gene Therapy Unknown Small Molecule Discovery NUMBER OF DRUGS Preclinical Phase I ## ## ## ##

  • Ambulatory Care
  • Aerie Pharmaceuticals, Inc.
  • Alcon, Inc.
  • Allergan plc
  • Santen Pharmaceutical Co., Ltd.

Monoclonal antibodies (mAbs) are the newest class of drugs, predominately used in the treatment of psoriasis.

  • Ambulatory Care
  • AbbVie Inc.
  • Allergan plc
  • Amgen Inc.
  • Apricus Biosciences, Inc.

Monoclonal antibodies and proteins have a longer trial duration than the therapy area average across all three phases.

  • Ambulatory Care
  • Adverum Biotechnologies, Inc.
  • Alcon, Inc.
  • Allergan plc
  • Astellas Pharma Inc.

Source: GlobalData, Pharma Intelligence Center [Accessed December 2018] Number of Drugs ## ## ## ## ## ## ## Polymer Biologic Cell Therapy Vaccine Protein Antisense Oligonucleotide RNAi Gene Therapy Recombinant Enzyme Peptide Bispecific Monoclonal Antibody Antibody Antisens

  • Ambulatory Care
  • Novartis AG
  • Ophthotech Corporation
  • Regeneron Pharmaceuticals, Inc.
  • Roche Group

The current study, conducted in collaboration with researchers at Baylor College of Medicine, isolated monoclonal antibodies from patients previously infected with norovirus.

  • Ambulatory Care
  • Healthcare
  • Therapy
  • United States
  • Illumina, Inc.

HOWEVER, THEY ARE LIKELY TO FACE COMPETITION FROM ROCHE YET AGAIN, AS THE COMPANY IS DEVELOPING A BI-MONOCLONAL ANTIBODY (RG-##) WHICH TARGETS BOTH VEGF AND ANG-##.

  • Ambulatory Care
  • Allergan plc
  • Clearside Biomedical, Inc.
  • Novartis AG
  • Regeneron Pharmaceuticals, Inc.

There are only a small number of other more novel molecule types, such as monoclonal antibodies (mAb), proteins and cell therapies, available in the market.

  • Ambulatory Care
  • Market Size
  • Allergan plc
  • Apricus Biosciences, Inc.
  • Pfizer Inc.

Dr Nakamura said there was even potential to one day work with pharmaceutical partners interested in targeting IL-## with a unique antibody or small molecule inhibitors.

  • Ambulatory Care
  • Hospital
  • Pharmaceutical
  • Therapy
  • Social Conditions

The majority of biologics are monoclonal Antibodies (mAbs), which have been highly clinically and commercially successful, with the majority being blockbuster drugs.

  • Ambulatory Care
  • Market Size
  • Amgen Inc.
  • Biologics, Inc.
  • Merck & Co., Inc.

A PHASE IA DOSE-ESCALATION STUDY OF THE ANTI-FACTOR D MONOCLONAL ANTIBODY FRAGMENT FCFD##S IN PATIENTS WITH GEOGRAPHIC ATROPHY.

  • Ambulatory Care
  • United States
  • Allergan plc
  • Novartis AG
  • Ophthotech Corporation

It' s a monoclonal [antibody].

  • Ambulatory Care
  • AbbVie Inc.
  • Clearside Biomedical, Inc.
  • pSivida Corp.
  • Santen Pharmaceutical Co., Ltd.

THERAPIES WITH NOVEL MECHANISMS OF ACTION AbbVie' s Humira, a monoclonal antibody against TNF-alpha that launched in 2016 for uveitis, provides a new therapy option for these patients.

  • Ambulatory Care
  • AbbVie Inc.
  • Amgen Inc.
  • AstraZeneca PLC
  • Eli Lilly & Co.

Brodalumab is a novel human monoclonal antibody that binds to the interleukin-## (IL-##) receptor and inhibits inflammatory signaling by blocking the binding of several types of IL-## to the receptor.

  • Ambulatory Care
  • Northern Europe
  • United Kingdom
  • Abbott Medical Optics, Inc.
  • Alcon, Inc.

Under the terms of consideration, AstraZeneca gains option rights to IPH##, an antibody targeting CD## monoclonal antibody, as well as four pre-clinical molecules from Innate.

  • Ambulatory Care
  • Therapy
  • World
  • Deals & Alliance
  • AstraZeneca PLC

Avidity' s platform seeks to combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapeutics to potentially overcome barriers to the delivery of oligonucleotides and target genetic drivers of disease.

  • Ambulatory Care
  • Dermatology
  • World
  • Company
  • Deals & Alliance

The company utilizes aptamer technology, a single strand of nucleic acid to targets such as PDGF, comparable to a monoclonal antibody.

  • Ambulatory Care
  • Eye Disease
  • United States
  • Company
  • Ophthotech Corporation

Syndax also develops SNDX-##, a monoclonal antibody that targets the CSF-## receptor.

  • Ambulatory Care
  • Immunology
  • Pharmaceutical
  • Therapy
  • Genentech, Inc.

Completed ##-Oct-2014 ##. ## Product Description Monoclonal antibody conjugate was under development for the treatment of cancer and hematological tumors.

  • Ambulatory Care
  • Healthcare
  • Pharmaceutical
  • United States
  • Montefiore Medical Center

Its core business develops three immunotherapy platforms including DC vaccines to kill tumor cells; T-cell receptor (TCR) detects and kills tumor cells and T-cell-specific monoclonal antibodies (TAB' s), helps to remove unwanted T cells from the body.

  • Ambulatory Care
  • Pharmaceutical
  • United States
  • M&A
  • Sandoz Inc.

At Regeneron she oversaw the development of the anti-PD-## monoclonal antibody Cemiplimab (REGN##) and the bi-specific T cell-engaging antibody REGN1979, targeting CD## and CD##.

  • Ambulatory Care
  • Pharmaceutical
  • United States
  • Company
  • Molecular Partners AG

The prominent features of this report are - ##.

  • Ambulatory Care
  • Health Services
  • Pharmaceutical
  • World
  • Product Initiative

Its core business develops three immunotherapy platforms including DC vaccines to kill tumor cells; T-cell receptor (TCR) detects and kills tumor cells and T-cell-specific monoclonal antibodies (TAB' s), helps to remove unwanted T cells from the body.

  • Ambulatory Care
  • Dermatology
  • United States
  • Company Financials
  • Almirall, S.A.

SAR##, a T-cell engaging multi-specific monoclonal antibody, entered Phase ## for the treatment of leukemia.

  • Ambulatory Care
  • Healthcare
  • Medical Device
  • United States
  • Company

The company provides monoclonal antibodies treatment for various diseases.

  • Ambulatory Care
  • Healthcare
  • Therapy
  • United States
  • Capricor Therapeutics, Inc.

The prominent features of this report are - ##.

  • Ambulatory Care
  • Clinical Trial
  • Pharmaceutical
  • World
  • Product Initiative

The company' s pipeline products include PAT-SC## an immunoglobulin M (IgM) type antibody used for the treatment of gastric cancer; PAT-SM## is a fully human monoclonal antibody (mAb) of the IgM type for treating melanoma and multiple myeloma; PAT-LM## used to treat multi

  • Ambulatory Care
  • Healthcare
  • Pharmaceutical
  • Israel
  • Beth Israel Deaconess Medical Center, Inc.

LANDIS IS CURRENTLY PRESIDENT OF THE BOARD OF EXELEAD, A LIPID DRUG DELIVERY CMO, AND SERVES ON THE BOARD OF SYMPHOGEN, A COMPANY DEVELOPING MIXTURES OF MONOCLONAL ANTIBODIES AGAINST ONCOLOGY TARGETS, WHERE HE CHAIRS THE DEVELOPMENT COMMITTEE.

  • Ambulatory Care
  • Pharmaceutical
  • United States
  • Company
  • pSivida Corp.

TRC## is a human/ murine chimeric IgG## monoclonal antibody that inhibits angiogenesis and tumor growth with potential antiangiogenic and antineoplastic activities.

  • Ambulatory Care
  • Japan
  • United States
  • Company
  • Santen Pharmaceutical Co., Ltd.

TECENTRIQ is a monoclonal antibody designed to bind with a protein called PD-L##.

  • Ambulatory Care
  • North America
  • United States
  • Market Size
  • Biolase, Inc.