Frontier Pharma: Glioblastoma Multiforme - Cancer Immunotherapies Dominate First-in-Class Product Innovation

Frontier Pharma: Glioblastoma Multiforme - Cancer Immunotherapies Dominate First-in-Class Product Innovation

  • September 2016
  • Report ID: 4193680
Frontier Pharma: Glioblastoma Multiforme - Cancer Immunotherapies Dominate First-in-Class Product Innovation

Summary

Glioblastoma multiforme (GBM) is the most common and aggressive type of human brain tumor, accounting for 15.4% of all primary brain tumors. GBM constitutes 60–75% of all astrocytomas – a cancer of the brain originating in a particular type of glial cell in the cerebrum called astrocytes (NCI, 2013a; ABTA, 2016a). It is most common in the elderly, with a peak incidence rate between the ages of 55 and 84, and a median age of diagnosis of 64 (Nelson et al., 2012; Thakkar et al., 2014).

Glioblastoma multiforme (GBM) has a low incidence and prevalence population in the US and EU, with the annual incidence estimated to be three to four cases per 100,000 people. There is a poor prognosis associated with the current standard of care, which is surgical resection followed by radiation therapy and temozolomide chemotherapy, with an associated median survival duration of 12–14 months (Johnson and O’Neill, 2011). There is a limited number of approved drugs for GBM, and these are subject to regional variations. Gliadel and temozolomide are the most widely approved globally, and are cytotoxic chemotherapies that are associated with more toxicity than targeted treatments.

The GBM cancer pipeline is moderately sized, with 512 products active across all stages of development. The range of mechanisms of action employed by these compounds is also highly diverse, especially in comparison with the existing market landscape. More pertinently, there is a large proportion of breakthrough innovations in this pipeline.
It is identified that 120 first-in-class programs in the GBM pipeline, acting on 86 first-in-class molecular targets. This accounts for 31% of all products with a disclosed molecular target, and reflects the high degree of innovation in this indication.

The report “Frontier Pharma: Glioblastoma Multiforme - Cancer Immunotherapies Dominate First-in-Class Product Innovation” analyzes innovation in GBM, in the context of the overall pipeline and current market landscape. In addition, it analyzes the deals landscape surrounding first-in-class products, and pinpoints opportunities for in-licensing.

In particular, this report includes analysis of the following -
- Provides a brief introduction to GBM, including symptoms, pathophysiology, and an overview of pharmacotherapy and treatment algorithms
- Provides comprehensive analysis of the pipeline for first-in-class therapies, analyzed on the basis of stage of development, molecule type and molecular target.
- This report help to Identify and assessment of first-in-class molecular targets, with a particular focus on early-stage programs for which clinical utility has yet to be evaluated, as well as literature reviews on novel molecular targets.

Scope

- The report analyzes innovation in GBM, in the context of the overall pipeline and current market landscape. In addition, it analyzes the deals landscape surrounding first-in-class products, and pinpoints opportunities for in-licensing.
- A brief introduction to GBM, including symptoms, pathophysiology, and an overview of pharmacotherapy and treatment algorithms.
- The changing molecular target landscape between the market and the pipeline, including particular focal points of innovation in the pipeline.
- A comprehensive review of the pipeline for first-in-class therapies, analyzed on the basis of stage of development, molecule type and molecular target.
- Identification and assessment of first-in-class molecular targets, with a particular focus on early-stage programs for which clinical utility has yet to be evaluated, as well as literature reviews on novel molecular targets.
- Assessment of the licensing and co-development deal landscape for GBM therapies.

Reasons to buy

- Understand the current clinical and commercial landscape, including a comprehensive study of disease pathogenesis, diagnosis, prognosis and the available treatment options.
- Visualize the composition of the GBM market in terms of dominant molecule types and targets, highlighting what the current unmet needs are and how they can be addressed. This knowledge allows a competitive understanding of the gaps in the current market.
- Analyze the GBM pipeline, stratified by stage of development, molecule type and molecular target.
- Assess the therapeutic potential of first-in-class targets. Using a proprietary matrix, first-in-class products have been assessed and ranked according to clinical potential. Promising early-stage targets have been further reviewed in greater detail.
- Identify commercial opportunities in the GBM deals landscape by analyzing trends in licensing and co-development deals.
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Country=World Industry=Cancer ParentIndustry=Pathology Date=201609 Topic=MarketReport Publisher=GBIResearch Price=7000