Diffuse Large B-Cell Lymphoma Drug Profiles and Clinical Trials- Global Trends and Analysis Review, H2 2017

Diffuse Large B-Cell Lymphoma Drug Profiles and Clinical Trials- Global Trends and Analysis Review, H2 2017

  • January 2018 •
  • 532 pages •
  • Report ID: 5281804 •
  • Format: PDF
Lymphoma is a cancer type where uncontrollable growth of lymphocytes (WBCs) initiating from lymph glands or lymphatic tissue or other parts of the lymphatic system, including bone marrow, tonsils, testicles, spleen and lymph nodes.

This excess growth of lymphocytes often accumulates in lymph nodes. Though this accumulation can occur in any body part, commonly affected parts are armpits, neck and groin and rarely in lungs or bones.

The non-inheritable and non-contageous disease is one of the common types of cancer but can be treated with patients’ life expectancy remaining quite large post-treatment.

Genomic alterations in lymphocytes cause damage to the lifecycle of these cells, boosting the cell division rate or affecting the death period. However, causes for such gene changes are yet to be determined.

Phases-

Phases of Lymphoma cancer-
-Single group of lymph nodes (above or below diaphragm)
-Multiple group of lymph nodes are affected(above or below diaphragm)
-Expands to both sides of diaphragm
-Expands to bone marrow or other body parts

Types of Lymphoma Cancer-
Though two types of Lymphoma are defined, it is often difficult to determine the exact sub-type of Lymphoma.

* Hodgkin Lymphoma
In Hodgkin Lymphoma, the cancer cells called Reed-Sternberg (RS) cells, have a characteristic appearance under microscope.

Further subtypes-
Nodular Sclerosis: Lymph nodes contain Reed-Sternberg cells mixed with normal white blood cells

Mixed Cellularity: Lymph nodes contain several Reed-Sternberg cells in addition to several other cell types

Lymphocyte-rich: Lymph nodes contain several normal- appearing lymphocytes and classic Reed-Sternberg cells

Lymphocyte-depleted: Lymph nodes contain large volume of Reed-Sternberg cells and few normal lymphocytes

Nodular lymphocyte-predominant Hodgkin lymphoma: Lymph nodes contain several abnormal B cells and Reed-Sternberg cells are rarely observed

* Non-Hodgkin Lymphoma
Unlike Hodgkin Lymphoma, the cancer cells called Reed-Sternberg cells are absent in this subtype of Lymphoma

High grade NHL

* B-cell NHL Lymphoma
Diffuse large B-cell (DLBCL): Abnormal growth of large B-Cells in different body parts

Intravascular B-Cell: Occurs due to explosion of lymphocytes within tiny vessels with no involvement of the organ parenchyma

Primary mediastinal large B-cell: Large neoplastic cells with B-cell derivation are observed

Burkitt: Most aggressive form, classified as endemic (African) type, sporadic type and HIV related

Primary central nervous system: DLBCL sub-type affecting the brain and or spinal cord

* T-cell NHL Lymphoma
Peripheral T-cell (PTCL NOS): Abnormal growth of T-cells which are not specified under any category

Anaplastic large cell: It can occur in the skin or in other organs throughout the body

Angioimmunoblastic T-cell: the body’s immune system does not recognize, and consequently destroys, its own cells and tissues

Enteropathy-associated: occurs in the intestines and is mostly associated with celiac disease

Nasal-type NK/T-cell: Natural killer cells often affecting the nasal area, trachea, gastrointestinal tract, or skin

Hepatosplenic T-cell: Abnormal growth of T-cells in liver or spleen

Lymphoblastic: The T-cells outgrow in number when a bone marrow cell develops alterations in its gene code

Low Grade NHL
Follicular: B-cells are affected; Enlargement of the lymph nodes in the neck, underarm, stomach, groin

Small lymphocytic: B-lymphocytes, with enlarged nodes affecting neck, armpit or groin

Lympho-plasmacytic: Enlarged cells make varying volumes of immunoglobin M protein in the blood, making it thick (condition referred to as Waldenstrom macroglobulinemi)

MALT Lymphoma (Gastric and Non-gastric): mucosa-associated lymphoid tissue (MALT) starts outside lymph nodes, usually in lymphatic tissue in the mucous membranes or tissues lining organs

Splenic marginal zone: The NHL sub-type affects spleen, bone marrow and blood

Nodal marginal zone: Mostly occurs in lymph nodes and rarely in spleen or bone marrow
Diffuse Large B-Cell Lymphoma clinical trials report from VPA Research provides comprehensive analysis and trends in global Diffuse Large B-Cell Lymphoma disease clinical trials. The research work analyzes the evolution of Diffuse Large B-Cell Lymphoma clinical trial trends across countries and regions.

The report focuses on drugs and therapies being evaluated for Diffuse Large B-Cell Lymphoma treatment in active clinical development phases including phase 1, phase 2, phase 3 and phase 4 clinical trials. The report also provides trials information by region, key countries, phases, trial status and sponsor types.

Our experienced database team dynamically updates the clinical trials data from several sources including Clinical trial registries, conferences, journals and company releases etc. Further, data is presented in user friendly manner offering quick access to Diffuse Large B-Cell Lymphoma clinical trials.

Major drugs under development in Diffuse Large B-Cell Lymphoma are provided in the report along with their details of Mechanism of Action, Route of Administration, Target, therapy, molecule and class.

Scope of the Report-
- Number of Diffuse Large B-Cell Lymphoma clinical trials across regions- Asia and Oceania, Europe, Middle East Africa and Americas
- Trial information by Phase and Subjects recruited
- Trial information by status, type, sponsor type
- Drugs used for treatment of Diffuse Large B-Cell Lymphoma
- Both observational and interventional trials analyzed
- Success rates of trials are analyzed
- Trends in enrollment over the past ten years identified
- Leading sponsors of Diffuse Large B-Cell Lymphoma clinical trials worldwide are listed

Reasons to Buy-
- Track competition and design competitive advantages
- Identify right partners to associate with for further research
- Evaluate potential opportunities available in further clinical trials of the disease
- Formulate business development strategies through success rates of clinical trials
- Identify quick markets for recruiting subjects based on trials count by each market
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