Drug Overview: Fasenra

Drug Overview: Fasenra

  • February 2018 •
  • 23 pages •
  • Report ID: 5391436 •
  • Format: PDF
Drug Overview
Fasenra (benralizumab; AstraZeneca/Kyowa Hakko Kirin) is a humanized monoclonal antibody which binds to the alpha chain of the interleukin (IL)-5 receptor on eosinophils and therefore depletes them. Elevated eosinophils are related to the cause and severity of asthma, as well as to asthma exacerbations. This mechanism of action differs from Nucala (mepolizumab; GlaxoSmithKline) and Cinqair (reslizumab; Teva), which bind to the IL-5 ligand, and this is proposed to lead to a faster onset of action.