About 100 reports

  • Number of Glaucoma Drugs in Early Stage Development by Molecule Type
  • PIPELINE PRODUCTS - EARLY STAGE PIPELINE

Stem Cell Therapy Peptide Fusion Protein Antisense RNAi Oligonucleotide Antibody Synthetic Peptide Recombinant Protein Protein Biologic Antisense Oligonucleotide Monoclonal Antibody Gene Therapy Unknown Small Molecule Discovery NUMBER OF DRUGS Preclinical Phase I ## ## ## ##

  • Ophthalmology
  • Aerie Pharmaceuticals, Inc.
  • Alcon, Inc.
  • Allergan plc
  • Santen Pharmaceutical Co., Ltd.
  • Ophthalmology, Global, Table of all Clinical Stage Pipeline Products, 2016 Part 9
  • Ophthalmology Therapeutics Market, Global, Clinical Trial Duration by Stage of

Monoclonal antibodies and proteins have a longer trial duration than the therapy area average across all three phases.

  • Cough And Cold
  • Ophthalmology
  • Adverum Biotechnologies, Inc.
  • Alcon, Inc.
  • Allergan plc

Source: GlobalData, Pharma Intelligence Center [Accessed December 2018] Number of Drugs ## ## ## ## ## ## ## Polymer Biologic Cell Therapy Vaccine Protein Antisense Oligonucleotide RNAi Gene Therapy Recombinant Enzyme Peptide Bispecific Monoclonal Antibody Antibody Antisens

  • Ophthalmology
  • Novartis AG
  • Ophthotech Corporation
  • Regeneron Pharmaceuticals, Inc.
  • Roche Group

HOWEVER, THEY ARE LIKELY TO FACE COMPETITION FROM ROCHE YET AGAIN, AS THE COMPANY IS DEVELOPING A BI-MONOCLONAL ANTIBODY (RG-##) WHICH TARGETS BOTH VEGF AND ANG-##.

  • Ophthalmology
  • Allergan plc
  • Clearside Biomedical, Inc.
  • Novartis AG
  • Regeneron Pharmaceuticals, Inc.

For example, Ustekinumab (Stelara), a Janssen Biotech brand, is a human monoclonal antibody used for the treatment of plaque psoriasis in the USA, Canada and Europe.

  • Cough And Cold
  • Ophthalmology
  • Market Size
  • Novartis AG
  • Pfizer Inc.

Monoclonal antibodies such as mepolizumab and omalizumab are sometimes effective.

  • Cough And Cold
  • China
  • Demand
  • Market Size
  • Trade

Dr Nakamura said there was even potential to one day work with pharmaceutical partners interested in targeting IL-## with a unique antibody or small molecule inhibitors.

  • Cancer
  • Cough And Cold
  • Ophthalmology
  • Pharmaceutical
  • Therapy

Monoclonal antibodies such as mepolizumab and omalizumab are sometimes effective.

  • Cough And Cold
  • China
  • Demand
  • Market Size
  • GlaxoSmithKline plc
  • depicts the distribution of approved / clinical products targeting back of the eye
  • 3. INTRODUCTION

THE VARIOUS TYPES OF ANTIBODIES THAT ARE UNDER DEVELOPMENT INCLUDE MONOCLONAL ANTIBODIES, ANTIBODY FRAGMENTS AND BISPECIFIC ANTIBODIES.

  • Ophthalmology
  • United States
  • Alcon, Inc.
  • Allergan plc
  • Novartis AG
  • 12.1 BIBLIOGRAPHY

A PHASE IA DOSE-ESCALATION STUDY OF THE ANTI-FACTOR D MONOCLONAL ANTIBODY FRAGMENT FCFD##S IN PATIENTS WITH GEOGRAPHIC ATROPHY.

  • Ophthalmology
  • United States
  • Allergan plc
  • Novartis AG
  • Ophthotech Corporation

Avastin contains bevacizumab, an anti-VEGF humanized monoclonal antibody.

  • Ophthalmology
  • Bayer AG
  • Hoffmann-La Roche Inc.
  • Novartis AG
  • Regeneron Pharmaceuticals, Inc.
  • 9.10.3 DEXAMETHASONE ACETATE (DEXNP)

It' s a monoclonal [antibody].

  • Ophthalmology
  • AbbVie Inc.
  • Clearside Biomedical, Inc.
  • pSivida Corp.
  • Santen Pharmaceutical Co., Ltd.
  • THE CURRENT CHALLENGES IN OPHTHALMOLOGY ARE TO DESIGN DRUGS WITH GREATER EFFICACY, MINIMALLY INVASIVE MODE OF ADMINISTRATION, AND LESS FREQUENT ADMINISTRATION
  • OPHTHALMOLOGY DRUGS WITH HIGHEST SALES IN THE 7MM

THERAPIES WITH NOVEL MECHANISMS OF ACTION AbbVie' s Humira, a monoclonal antibody against TNF-alpha that launched in 2016 for uveitis, provides a new therapy option for these patients.

  • Ophthalmology
  • AbbVie Inc.
  • Amgen Inc.
  • AstraZeneca PLC
  • Eli Lilly & Co.

Brodalumab is a novel human monoclonal antibody that binds to the interleukin-## (IL-##) receptor and inhibits inflammatory signaling by blocking the binding of several types of IL-## to the receptor.

  • Ophthalmology
  • Northern Europe
  • United Kingdom
  • Abbott Medical Optics, Inc.
  • Alcon, Inc.

It contains bevacizumab, an anti-VEGF humanized monoclonal antibody.

  • Ophthalmology
  • Bayer AG
  • F. Hoffmann-La Roche Ltd.
  • Novartis AG
  • Regeneron Pharmaceuticals, Inc.
  • MONOCLONAL ANTIBODY TO INHIBIT COMPLEMENT C5 FOR AGE RELATED MACULAR DEGENERATION - DRUG PROFILE
  • PRODUCTS UNDER INVESTIGATION BY UNIVERSITIES/INSTITUTES, H2 2018

IFX-## is humanized monoclonal antibody that targets complement activation product C##a.

  • Monoclonal Antibody
  • Ophthalmology
  • Pharmaceutical
  • Therapy
  • Alexion Pharmaceuticals, Inc.
  • MONOCLONAL ANTIBODY TO INHIBIT VEGF FOR OPHTHALMOLOGY AND ONCOLOGY - DRUG PROFILE
  • MONOCLONAL ANTIBODY TO INHIBIT SCG3 FOR METABOLIC DISORDERS, ONCOLOGY AND OPHTHALMOLOGY - DRUG PROFILE

It also provides monoclonal antibodies for the treatment of cancer.

  • Ophthalmology
  • Therapy
  • United States
  • Product Initiative
  • Formycon AG
  • Products under Development by Companies, H1 2018
  • Vascular Endothelial Growth Factor B (VEGF Related Factor or VEGFB) - Drug Profiles

Nesvacumab is a monoclonal antibody to Ang-##.

  • Ophthalmology
  • Therapy
  • World
  • Product Initiative
  • Regeneron Pharmaceuticals, Inc.
  • PRODUCTS UNDER DEVELOPMENT BY COMPANIES

Hoffmann-La Roche Ltd NA Genentech Inc; Novartis AG R& D Progress Research and Development Brief Ranibizumab (Lucentis) is a humanized monoclonal antibody fragment and a recombinant humanized IgO ## isotype designed to bind to and inhibit vascular endothelial growth fact

  • Eye Disease
  • Health Services
  • Monoclonal Antibody
  • Ophthalmology
  • Therapy
  • MONOCLONAL ANTIBODY TO INHIBIT VEGF FOR OPHTHALMOLOGY AND ONCOLOGY - DRUG PROFILE
  • GENE SIGNAL INTERNATIONAL SA

It also provides monoclonal antibodies for the treatment of cancer.

  • Ophthalmology
  • Pharmaceutical
  • United States
  • Product Initiative
  • Clearside Biomedical, Inc.

It is a humanized monoclonal antibody targeting interleukin-##.

  • Medical Biotechnology
  • Ophthalmology
  • United States
  • Product Initiative
  • Galapagos NV

Pasteur Institute NA NA MONOCLONAL ANTIBODY TO ANTAGONIZE FCGRIIA FOR AUTOIMMUNE ARTHRITIS, PULMONARY INFLAMMATION, SYSTEMIC ANAPHYLAXIS AND THROMBOCYTOPENIA - DRUG PROFILE Drug Name Company/ Institute Name Licensed From Company Development Partner Product Description

  • Cough And Cold
  • Therapy
  • United States
  • World
  • Product Initiative

Its strategy also involves designing human monoclonal antibodies that are far-reaching, are efficient, and have an impact.

  • Ophthalmology
  • F. Hoffmann-La Roche Ltd.
  • Novartis AG
  • Regeneron Pharmaceuticals, Inc.
  • Roche Group
  • Biosuperior Anti-VEGF in Ophthalmology - 4/4
  • Biosuperior Bispecific Anti-VEGF and Anti-VEGF Combinations in Ophthalmology - 2/2

The lead ADC program targets VEGFR## and is expected to reach the clinic in 2016. ## Precl ## ## HLX##; HLX- ## Metastatic colorectal cancer Rec humanized monoclonal antibody Vascular endothelial growth factor receptor ## (VEGF-R##) Shanghai Henlius Biotech (subsidiary of Fosun Pharma

  • Biosimilar
  • Ophthalmology
  • Targeted Therapy
  • Therapy
  • United States

The therapeutic drug candidate is a bispecific single domain antibody.

  • Ophthalmology
  • United States
  • World
  • Product Initiative
  • EyeGate Pharmaceuticals, Inc.
  • MONOCLONAL ANTIBODY TO INHIBIT VEGF FOR OPHTHALMOLOGY AND ONCOLOGY
  • MONOCLONAL ANTIBODY TO INHIBIT SCG3 FOR METABOLIC DISORDERS, ONCOLOGY AND OPHTHALMOLOGY - DRUG PROFILE

It also provides monoclonal antibodies for the treatment of cancer.

  • Cough And Cold
  • Medical Biotechnology
  • Ophthalmology
  • United States
  • Product Initiative
  • R&D Progress
  • RETINOPATHY OF PREMATURITY - PIPELINE BY PROTHERAGEN INC, H2 2018

The guide covers therapeutics under Development by Companies / Universities / Institutes, the molecules developed by Companies in Pre-Registration, Phase III, Phase II and Preclinical stages are ##, ##, ## and ## respectively.

  • Eye Disease
  • Health Services
  • Ophthalmology
  • Pathology
  • Therapy

Avidity' s platform seeks to combine the tissue selectivity of monoclonal antibodies and the precision of oligonucleotide-based therapeutics to potentially overcome barriers to the delivery of oligonucleotides and target genetic drivers of disease.

  • Healthcare
  • Hospital
  • Ophthalmology
  • Pharmaceutical
  • Therapy
  • Vascular Endothelial Growth Factor B (VEGF Related Factor or VEGFB) - Drug Profiles

Nesvacumab is a monoclonal antibody to Ang-##.

  • Eye Disease
  • Ophthalmology
  • Pharmaceutical
  • Targeted Therapy
  • Therapy
  • Product profile (late stage): brolucizumab
  • Product profile: Avastin

Avastin is a vascular endothelial growth factor (VEGF)-targeted monoclonal antibody originally developed for cancer.

  • Ophthalmology
  • United States
  • Novartis AG
  • Ohr Pharmaceutical Inc.
  • Ophthotech Corporation